Neuroimaging depression and anxiety in essential tremor: A diffusion tensor imaging study

Şengül, Yıldızhan; Otcu, Hafize; Üstün, İsmet; Şengül, Hakan Serdar; Cersonsky, Tess E.K.; Alkan, Alpay; Louis, Elan D.

doi:10.1016/j.clinimag.2019.06.016

Cited by 19 publications

(16 citation statements)

References 56 publications

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“…The VI and VII lobes of vermis in the posterior cerebellum, also known as limbic cerebellum, may participate in emotional regulation through connection with amygdala 16,17 . Besides, using a diffusion tensor imaging, Sengul et al 25 recently revealed that depression and anxiety in patients with ET could be based on the structural changes in amygdale, and ventrolateral prefrontal cortex/precuneus, respectively. Shared neural anatomy or circuits may be account for their co‐occurrence.…”

Section: Discussionmentioning

confidence: 99%

Non‐motor symptoms are associated with midline tremor in essential tremor

et al. 2020

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including cognition deficiency, psychiatry symptoms, sleep disruption, and sensory abnormalities, has recently been reported in ET syndrome. 2 Besides, accumulating evidence on different etiologies, pathophysiologies, and clinical features has demonstrated the heterogeneity of ET syndrome, even giving rise to a new placeholder, ET-plus. 2,3 Due to such heterogeneity, its disease sub-types should be extensively studied to understand the inherent mechanisms of ET syndrome.

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Section: Discussionmentioning

confidence: 99%

Non‐motor symptoms are associated with midline tremor in essential tremor

et al. 2020

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“…Our results showed a similar prevalence with the ETh group seemingly having worse depression/apathy or anxiety symptoms. Neuroimaging studies have confirmed the hypothesis that cerebello‐thalamo‐cortical pathway disturbance underlies the affective disorder pathology in patients with ET 29,30 . Therefore, patients with ETh may suffer worse cerebellar dysfunction and thus result in more obvious affective disturbance.…”

Section: Discussionmentioning

confidence: 77%

Distinct non‐motor features of essential tremor with head tremor patients

Peng

et al. 2020

Acta Neurol Scand

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Background There have been few comprehensive scale studies on the non‐motor symptoms (NMS) of patients with essential tremor (ET) with head tremor (ETh) and those with ET without head tremor (ETol). We aimed to explore the motor symptoms and NMS of these two subgroups. Methods We enrolled 199 patients with ET (125, ETol; 74 ETh) and 132 healthy controls. We evaluated motor symptoms using the Fahn‐Tolosa‐Marin Tremor Rating Scale (TRS) and NMS using the Non‐Motor Symptom Scale (NMSS). We compared NMSS scores and the prevalence of each NMS between the patient subgroups. Finally, we conducted a logistic regression analysis of the correlation between head tremor and NMS severity, as well as other determinants. Results There were no significant between‐subgroup differences in demographic characteristics. Further, they presented similar tremor clinical manifestation; however, the ETh subgroup showed a higher prevalence of rest tremor, feeling of sadness, forgetting things or events, and swallowing difficulty, as well as TRS scores, compared with the ETol subgroup. Both patient subgroups showed high scores and prevalence (>50%) in difficulty falling asleep. Logistic regression analysis indicated age as a tremor severity determinant; further, head tremor and tremor severity were NMS determinants. Conclusion Both patient subgroups presented various NMS including sleep disturbances, cognitive deficits, and affective disorders. The ETh subgroup showed a high prevalence of certain NMS aspects including memory and affective disorder; further, they had aggravated NMS. ET with both upper limb tremor and head tremor may be regarded as a more severe clinical subtype.

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“…The most recent evolution of the frontal-striatal-cerebellar circuit model has gained increasing attention, and this model emphasizes that the posterior cerebellum lobe, anterior cingulate cortex and ventromedial prefrontal cortex, as vital components of this circuit might be associated with depression-related functional impairments, such as problem solving, decision making, self-referential problems and negative ruminations [22,24]. Studies [24][25][26] using electroencephalography (EEG), magnetoencephalography (MEG), positron emission tomography (PET), singlephoton emission computed tomography (SPECT), magnetic resonance spectroscopy (MRS), structural and functional magnetic resonance imaging have demonstrated that abnormalities in frontal-striatal-cerebellar circuits are associated with major depressive disorder, ET with depression, PD with depression and other chronic diseases with depression, such as chronic pain with depression. Consistent with these studies, our findings also showed that not only local FC but also inter-ROI FC changes in the frontal-cerebellar-anterior cingulate cortex circuit are involved in depressed ET patients.…”

Section: Depression Can Be a Primary Phenomenon In Etmentioning

confidence: 99%

Altered local and matrix functional connectivity in depressed essential tremor patients

Duan

Zhou

et al. 2021

BMC Neurol

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Background Depression in essential tremor (ET) has been constantly studied and reported, while the associated brain activity changes remain unclear. Recently, regional homogeneity (ReHo), a voxel-wise local functional connectivity (FC) analysis of resting-state functional magnetic resonance imaging, has provided a promising way to observe spontaneous brain activity. Methods Local FC analyses were performed in forty-one depressed ET patients, 49 non-depressed ET patients and 43 healthy controls (HCs), and then matrix FC and clinical depression severity correlation analyses were further performed to reveal spontaneous neural activity changes in depressed ET patients. Results Compared with the non-depressed ET patients, the depressed ET patients showed decreased ReHo in the bilateral cerebellum lobules IX, and increased ReHo in the bilateral anterior cingulate cortices and middle prefrontal cortices. Twenty-five significant changes of ReHo clusters were observed in the depressed ET patients compared with the HCs, and matrix FC analysis further revealed that inter-ROI FC differences were also observed in the frontal-cerebellar-anterior cingulate cortex pathway. Correlation analyses showed that clinical depression severity was positively correlated with the inter-ROI FC values between the anterior cingulate cortex and bilateral middle prefrontal cortices and was negatively correlated with the inter-ROI FC values of the anterior cingulate cortex and bilateral cerebellum lobules IX. Conclusion Our findings revealed local and inter-ROI FC differences in frontal-cerebellar-anterior cingulate cortex circuits in depressed ET patients, and among these regions, the cerebellum lobules IX, middle prefrontal cortices and anterior cingulate cortices could function as pathogenic structures underlying depression in ET patients.

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Neuroimaging depression and anxiety in essential tremor: A diffusion tensor imaging study

Cited by 19 publications

References 56 publications

Non‐motor symptoms are associated with midline tremor in essential tremor

Non‐motor symptoms are associated with midline tremor in essential tremor

Distinct non‐motor features of essential tremor with head tremor patients

Altered local and matrix functional connectivity in depressed essential tremor patients

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