Neuroimaging evidence of gray and white matter damage and clinical correlates in progressive supranuclear palsy

Piattella, Maria Cristina; Pantano, P.; Bologna, Matteo; Sbardella, Emilia; Tona, Francesca; Formica, Alessandro; Petsas, Nikolaos; Berardelli, Alfredo

doi:10.1007/s00415-015-7779-3

Cited by 25 publications

(46 citation statements)

References 48 publications

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“…Diffusion tensor imaging (DTI) allows for the assessment of directional water diffusion and the interrogation of specific white‐matter tracts. White‐matter tract degeneration has been demonstrated to be a striking feature of PSP‐RS, with abnormalities observed predominantly in the SCP, cerebellum, body of the corpus callosum, cingulum, white‐matter laminar of the thalamus, and premotor aspects of the superior longitudinal fasciculus . The majority of these white‐matter tracts show greater degeneration in PSP‐RS compared with PD and MSA‐P .…”

Section: Structural Mrimentioning

confidence: 99%

“…White-matter tract degeneration has been demonstrated to be a striking feature of PSP-RS, with abnormalities observed predominantly in the SCP, cerebellum, body of the corpus callosum, cingulum, white-matter laminar of the thalamus, and premotor aspects of the superior longitudinal fasciculus. 63,[111][112][113][114][115][116][117][118][119][120][121][122][123][124] The majority of these white-matter tracts show greater degeneration in PSP-RS compared with PD 112,118,122,[125][126][127] and MSA-P. 72,118,126 Little data are currently available on the diagnostic utility of DTI measures, although the corpus callosum 113 and SCP 125 show high sensitivity and specificity in differentiating PSP-RS and PD. There is also evidence that adding DTI measures to the MRPI may help in the differentiation of PSP-RS from controls.…”

Section: Diffusion Imagingmentioning

confidence: 99%

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Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?

et al. 2017

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PSP is a pathologically defined neurodegenerative tauopathy with a variety of clinical presentations including typical Richardson's syndrome and other variant PSP syndromes. A large body of neuroimaging research has been conducted over the past two decades, with many studies proposing different structural MRI and molecular PET/SPECT biomarkers for PSP. These include measures of brainstem, cortical and striatal atrophy, diffusion weighted and diffusion tensor imaging abnormalities, [18F] fluorodeoxyglucose PET hypometabolism, reductions in striatal dopamine imaging and, most recently, PET imaging with ligands that bind to tau. Our aim was to critically evaluate the degree to which structural and molecular neuroimaging metrics fulfill criteria for diagnostic biomarkers of PSP. We queried the PubMed, Cochrane, Medline, and PSYCInfo databases for original research articles published in English over the past 20 years using postmortem diagnosis or the NINDS-SPSP criteria as the diagnostic standard from 1996 to 2016. We define a five-level theoretical construct for the utility of neuroimaging biomarkers in PSP, with level 1 representing group-level findings, level 2 representing biomarkers with demonstrable individual-level diagnostic utility, level 3 representing biomarkers for early disease, level 4 representing surrogate biomarkers of PSP pathology, and level 5 representing definitive PSP biomarkers of PSP pathology. We discuss the degree to which each of the currently available biomarkers fit into this theoretical construct, consider the role of biomarkers in the diagnosis of Richardson's syndrome, variant PSP syndromes and autopsy confirmed PSP, and emphasize current shortfalls in the field.

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Section: Structural Mrimentioning

confidence: 99%

Section: Diffusion Imagingmentioning

confidence: 99%

Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?

et al. 2017

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“…MRI studies have revealed gray matter abnormalities at multiple brain levels in both PSP and CBS: subcortical nuclei pathology is involved in both conditions, but PSP patients exhibit predominant midbrain atrophy and a limited involvement of frontal cortex pathology, while CBS patients display more evident cortical atrophy, particularly in peri-rolandic areas (4–7). Moreover, diffusion tensor imaging has revealed widespread white matter bundle damage, which suggests altered structural connectivity between cortical and subcortical structures, in both PSP and CBS patients (4–8).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, diffusion tensor imaging has revealed widespread white matter bundle damage, which suggests altered structural connectivity between cortical and subcortical structures, in both PSP and CBS patients (4–8). …”

Section: Introductionmentioning

confidence: 99%

Abnormal Resting-State Functional Connectivity in Progressive Supranuclear Palsy and Corticobasal Syndrome

et al. 2017

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BackgroundPathological and MRI-based evidence suggests that multiple brain structures are likely to be involved in functional disconnection between brain areas. Few studies have investigated resting-state functional connectivity (rsFC) in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). In this study, we investigated within- and between-network rsFC abnormalities in these two conditions.MethodsTwenty patients with PSP, 11 patients with CBS, and 16 healthy subjects (HS) underwent a resting-state fMRI study. Resting-state networks (RSNs) were extracted to evaluate within- and between-network rsFC using the Melodic and FSLNets software packages.ResultsIncreased within-network rsFC was observed in both PSP and CBS patients, with a larger number of RSNs being involved in CBS. Within-network cerebellar rsFC positively correlated with mini-mental state examination scores in patients with PSP. Compared to healthy volunteers, PSP and CBS patients exhibit reduced functional connectivity between the lateral visual and auditory RSNs, with PSP patients additionally showing lower functional connectivity between the cerebellar and insular RSNs. Moreover, rsFC between the salience and executive-control RSNs was increased in patients with CBS compared to HS.ConclusionThis study provides evidence of functional brain reorganization in both PSP and CBS. Increased within-network rsFC could represent a higher degree of synchronization in damaged brain areas, while between-network rsFC abnormalities may mainly reflect degeneration of long-range white matter fibers.

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“…DTI is a valuable noninvasive imaging technique for the assessment of the WM structure of the brain. In patients with PSP-RS, relative to PD patients and healthy controls, a greater WM degeneration (lower FA and higher MD) have been observed in the superior cerebellar peduncles, cerebellum, corpus callosum, cingulum, superior longitudinal fasciculus, and white matter laminar of thalamus (Blain et al, 2006;Canu et al, 2011;Erbetta et al, 2009;Ito, Makino, Shirai, & Hattori, 2008;Knake et al, 2010;Piattella et al, 2015;Saini et al, 2012;Surova et al, 2015). In patients with PSP-RS, relative to PD patients and healthy controls, a greater WM degeneration (lower FA and higher MD) have been observed in the superior cerebellar peduncles, cerebellum, corpus callosum, cingulum, superior longitudinal fasciculus, and white matter laminar of thalamus (Blain et al, 2006;Canu et al, 2011;Erbetta et al, 2009;Ito, Makino, Shirai, & Hattori, 2008;Knake et al, 2010;Piattella et al, 2015;Saini et al, 2012;Surova et al, 2015).…”

mentioning

confidence: 99%

Track density imaging in progressive supranuclear palsy: A pilot study

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et al. 2018

Human Brain Mapping

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Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by white matter (WM) changes in different supra‐ and infratentorial brain structures. We used track density imaging (TDI) to characterize WM microstructural alterations in patients with PSP‐Richardson's Syndrome (PSP‐RS). Moreover, we investigated the diagnostic utility of TDI in distinguishing patients with PSP‐RS from those with Parkinson's disease and healthy controls (HC). Twenty PSP‐RS patients, 21 PD patients, and 23 HC underwent a 3 T MRI diffusion‐weighted (DW) imaging. Then, we combined constrained spherical deconvolution and WM probabilistic tractography to reconstruct track density maps by calculating the number of WM streamlines traversing each voxel. Voxel‐wise analysis was performed to assess group differences in track density maps. A support vector machine (SVM) approach was also used to evaluate the performance of TDI for discriminating between groups. Relative to PD patients, decreases in track density in PSP‐RS patients were found in brainstem, cerebellum, thalamus, corpus callosum, and corticospinal tract. Similar findings were obtained between PSP‐RS patients and HC. No differences in TDI were observed between PD and HC. SVM approach based on whole‐brain analysis differentiated PD patients from PSP‐RS with an area under the curve (AUC) of 0.82. The AUC reached a value of 0.98 considering only the voxels belonging to the superior cerebellar peduncle. This study shows that TDI may represent a useful approach for characterizing WM alterations in PSP‐RS patients. Moreover, track density decrease in PSP could be considered a new feature for the differentiation of patients with PSP‐RS from those with PD.

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Neuroimaging evidence of gray and white matter damage and clinical correlates in progressive supranuclear palsy

Cited by 25 publications

References 48 publications

Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?

Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?

Abnormal Resting-State Functional Connectivity in Progressive Supranuclear Palsy and Corticobasal Syndrome

Track density imaging in progressive supranuclear palsy: A pilot study

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