Neuroimaging for drug addiction and related behaviors

Parvaz, Muhammad A.; Alia‐Klein, Nelly; Woicik, Patricia A.; Volkow, Nora D.; Goldstein, Rita Z.

doi:10.1515/rns.2011.055

Cited by 123 publications

(86 citation statements)

References 236 publications

(266 reference statements)

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“…The alpha frequency has often been associated with addiction (see Parvas, Alia-Klein, Woicik, Volkow & Goldstein, 2011), including findings of increased alpha activity during withdrawal from both heroin (Shufman et al, 1996) and cocaine (Alper, Chabot, Kim, Prichep & John, 1990). The exact functional nature of alpha frequency in these processes is uncertain; for example Reid, Flammino, Howard, Nilsen and Prichep (2008) report findings that suggest increased frontal cortical alpha power to be positively associated with cocaine-induced nervousness, but frontal cortical alpha coherence to be negatively associated with cue-induced cocaine-like high.…”

Section: Discussionmentioning

confidence: 99%

Alpha activity in the insula accompanies the urge to neutralize in sub-clinical obsessive-compulsive participants

Jones¹,

Bhattacharya²

2012

Journal of Behavioral Addictions

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Background and aims:The behavioural addiction model of obsessive-compulsive disorder (OCD) proposes that as compulsions successfully reduce obsession-provoked anxiety in the early stages of the disorder, their performance is rewarding and therefore potentially addictive. According to this theory, the urge to perform a compulsion or neutralization resembles craving in addiction, and ventral fronto-striatal reward circuitry is activated during compulsive or neutralizing behaviour, resembling substance addiction disorders. The current study used EEG source localisation to test this hypothesis by examining brain activity accompanying the urge to neutralize and covert neutralization. Methods: Two groups of non-clinical participants (15 Low-OC, 15 High-OC) performed a task in which the urge to neutralize was induced by supplying participants with an obsessive-compulsive-like thought. Source localised EEG activity was compared between a negative condition with high urge to neutralize, and a positive condition with low urge to neutralize, and correlations between brain activity and self-reported urge to neutralize were examined. Results: High-OC participants reported a significantly greater urge to neutralize than Low-OC participants, and the majority of participants reported performing covert neutralization during the experiment. Between-condition comparisons in the High-OC group revealed significantly greater alpha activity in the insula and vlPFC in the negative than the positive condition, which was significantly correlated with both urge to neutralize and later decrease in negative affect. Conclusions: The current results support the proposal that the urge to neutralize in OCD is neurally similar to craving in substance addiction, in agreement with the behavioural addiction model of OCD.

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Section: Discussionmentioning

confidence: 99%

Alpha activity in the insula accompanies the urge to neutralize in sub-clinical obsessive-compulsive participants

Jones¹,

Bhattacharya²

2012

Journal of Behavioral Addictions

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“…Further, Tammela et al (2010) reported that EEG activity in the beta range throughout food picture presentation is related to disinhibition in obese women with binge eating disorder. Excess EEG high beta activity has also been shown with respect to drug-induced stressful states of craving (for a review see: Parvaz et al 2011) which are described as comparable to states of food craving preceding overeating episodes Styn et al 2013). Therefore, high beta frequencies are target to inhibition in the reduction of stressful arousal in several neurofeedback protocols Gruzelier 2001, 2004;Paquette et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Neurofeedback Reduces Overeating Episodes in Female Restrained Eaters: A Randomized Controlled Pilot-Study

Schmidt

Martin

2015

Appl Psychophysiol Biofeedback

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Overeating episodes, despite of intentions to control weight, are a common problem among women. Recurring episodes of overeating and dietary failure have been reported to result in higher Body Mass Indexes and to induce severe distress even in non-clinical groups. Based on findings from physiological research on eating behavior and craving, as well as previous biofeedback studies, we derived a cue exposure based EEG neurofeedback protocol to target overeating episodes. The treatment was evaluated in a randomized controlled trial, comparing a neurofeedback group (NFG; n = 14) with a waiting list control group (WLG; n = 13) in a sub-clinical sample of female restrained eaters. At post-treatment, the number of weekly overeating episodes and subsequent distress were significantly reduced in the NFG compared to the WLG (p < .01; r > .50). In a 3 month follow-up, effects in the NFG remained stable. As secondary outcomes, perceived dieting success was enhanced after the treatment. At follow-up, additional beneficial effects on trait food craving were observed. Altogether, we found preliminary evidence for the cue exposure neurofeedback against overeating episodes in female restrained eaters, although specific effects and underlying mechanisms still have to be explored in future research.

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“…Functional neuroimaging is often used to assess the effectiveness of addiction treatments, given the strong evidence for neurological alterations at the basis of drug dependence (e.g., Parvaz, Alia-Klein, Woicik, Volkow, & Goldstein, 2011;Volkow, Wang, Fowler, & Tomasi, 2012). Functional neuroimaging provides an objective and quantifiable measure for evaluating changes with treatment beyond what can be gathered from self-report or behavior alone (Menossi et al, 2013).…”

Section: Treatment Of Methamphetamine Use Disordersmentioning

confidence: 99%