Neuroimaging in epilepsy

Roy, Trishit; Pandit, Alak

doi:10.4103/0972-2327.82787

Cited by 25 publications

(17 citation statements)

References 14 publications

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“…The risk for PCS is 5 times higher in patients with hippocampal sclerosis. Highest difference in MRI and CT findings was in patients with hippocampal sclerosis and cerebral malformations [ 6 , 7 ]. Maximal correlation of MRI and etiologic factor was found as for R=1.…”

Section: Discussionmentioning

confidence: 99%

Refractory Epilepsy-MRI, EEG and CT scan, a Correlative Clinical Study

Nikodijevic

Banevaâ€“Dolnenec

Petrovska-Cvetkovska

et al. 2016

Open Access Maced J Med Sci

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OBJECTIVES:Refractory epilepsies (RE), as well as, the surgically correctable syndromes, are of great interest, since they affect the very young population of children and adolescents. The early diagnosis and treatment are very important in preventing the psychosocial disability. Therefore MRI and EEG are highly sensitive methods in the diagnosis and localization of epileptogenic focus, but also in pre-surgical evaluation of these patients. The aim of our study is to correlate the imaging findings of EEG, MRI and CT scan in refractory symptomatic epilepsies, and to determine their specificity in detecting the epileptogenic focus.METHODS:The study was prospective with duration of over two years, open-labelled, and involved a group of 37 patients that had been evaluated and diagnosed as refractory epilepsy patients. In the evaluation the type and frequency of seizures were considered, together with the etiologic factors and their association, and finally the risk for developing refractory epilepsy was weighted. EEG and MRI findings and CT scan results were evaluated for their specificity and sensitivity in detecting the epileptogenic focus, and the correlation between them was analyzed.RESULTS:Regarding the type of seizures considered in our study, the patients with PCS (partial complex seizures) dominated, as opposed to those with generalized seizures (GS) (D=1.178, p < 0.05). Positive MRI findings were registered in 28 patients (75.7%). Most of them were patients with hippocampal sclerosis, 12 (42.8%), and also they were found to have the highest risk of developing refractory epilepsy (RE) (Odds ratio = 5.7), and the highest association between the etiologic factor and refractory epilepsy (p < 0.01). In detecting the epileptogenic focus, a significant difference was found (p < 0.01) between MRI and CT scan findings, especially in patients with hippocampal sclerosis and cerebral malformations. There was a strong correlation between the MRI findings and the etiologic factor (R = 1), and for CT scan and etiologic factor an R=0.75 correlation. There was a significant difference between imaging methods MRI/CT (p < 0.1), and CT/EEG (p < 0.05) in detecting the etiologic factor, and little difference was noticed between findings of EEG/MRI.CONCLUSION:Our study confirms that for an accurate diagnosis of refractory epilepsy in patients, a combination of neuroimaging and neurophysiologic methods is required. MRI showed to be highly sensitive in detecting the etiologic factor in RE patients, whereas EEG was sensitive in localization of the epileptogenic focus, with high correlation between these two methods. An early diagnosis of these patients is very important in having a better therapeutic response and prognosis for them.

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Section: Discussionmentioning

confidence: 99%

Refractory Epilepsy-MRI, EEG and CT scan, a Correlative Clinical Study

Nikodijevic

Banevaâ€“Dolnenec

Petrovska-Cvetkovska

et al. 2016

Open Access Maced J Med Sci

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“…Single-photon emission computerized tomography (SPECT) is a nuclear medicine imaging modality which uses gamma rays and allows the quantitative and qualitative assessment of regional cerebral blood flow [35,36]. SPECT provides imaging of the regional anatomy and monitors the level of biological activity (cerebral blood flow) at each place in the 3D region analyzed.…”

Section: Functional Neuroimaging Modalities In Pediatric Epilepsymentioning

confidence: 99%

Neuroimaging in Pediatric Epilepsy

2019

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Pediatric epilepsy presents with various diagnostic challenges. Recent advances in neuroimaging play an important role in the diagnosis, management and in guiding the treatment of pediatric epilepsy. Structural neuroimaging techniques such as CT and MRI can identify underlying structural abnormalities associated with epileptic focus. Functional neuroimaging provides further information and may show abnormalities even in cases where MRI was normal, thus further helping in the localization of the epileptogenic foci and guiding the possible surgical management of intractable/refractory epilepsy when indicated. A multi-modal imaging approach helps in the diagnosis of refractory epilepsy. In this review, we will discuss various imaging techniques, as well as aspects of structural and functional neuroimaging and their application in the management of pediatric epilepsy.

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“…The majority (81.2%, n=95) of respondents agreed that sharing images with patients was a good idea. Respondents indicated overall agreement with several factors which can contribute to patient engagement [4,5,6] including:…”

Section: P155mentioning

confidence: 99%

Poster Presentations - Imaging Technologies and Informatics

2018

Proceedings of UK Radiological Conference 2018

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The purpose of the 2017 Conference was to review actions taken and developments since the 2012 Bonn conference, especially focusing on actions taken by all relevant parties in line with the Bonn Call-for-Action. This will enable review of the overall approach to implementation of these actions and harmonization of activities between international organizations and other stakeholders, as well as allowing stakeholders to look ahead at new developments impacting on radiation protection in medicine. Whilst the medical benefits of the use of ionizing radiation in medicine are unquestionable, there is growing evidence of unintended and unnecessary use of radiation in medicine. The conference dealt with justification and optimization in medical exposure; safety in medical use of ionizing radiation; and radiation protection of medical staff and public when ionizing radiation is used for diagnosis, intervention, therapy or research. The 2017 conference was attended by 534 participants from 97 countries. Invited papers from authorities in the field were supplemented by approximately 200 contributed papers and 80 posters. This presentation will outline the structure of the 2017 Conference, and offer a summary of key points. IMAGING TECHNOLOGIES & INFORMATICS P153 An investigation into the impact of aging on the performance of LCD 2.4 MP colour display monitor when visualising low contrast detail using a CDRAD phantom Sadeq Al-Murshedi; Peter Hogg; khouloud Alzyoud; Andrew England Salford University Background: To Investigate the influence of deterioration of 2.4MP LCD colour display monitor luminance as a result of the longterm use on its performance in visualising low contrast details with different image quality. Method: A 2.4 MP LCD colour display monitor was set at three different maximum luminance values (250, 140, and 116 cd/m2) to simulate the monitor in initial use, after 1 year and after 4.6 years. This was based on the monitor being used 24/7. Six CDRAD images were generated using adults chest radiography protocols with different levels of image quality. The images were assessed on the monitor by four observers in three different sessions with the three different levels of luminance to investigate its influence on image scoring. Results: Data analysis was conducted via repeated measures of variance (ANOVA). The overall ANOVA has shown that there is no significant difference (p=0.30) between the three ages (the three levels of luminance) of the monitor. Furthermore, the pairwise comparisons between the mean scores of monitor in initial use with that of the other two ages have shown that there is no significant difference among them p=1.00 and p=1.00 respectively. Conclusion: The study shows that the monitor aging has no significant influence on its performance for detection of low contrast details and the monitor can be used for clinical practice without needing to be replaced. P154 An investigation of the influence of image viewing parameter settings on the performance of 5 MP monochrome liquid crystal display (LC...

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Neuroimaging in epilepsy

Cited by 25 publications

References 14 publications

Refractory Epilepsy-MRI, EEG and CT scan, a Correlative Clinical Study

Refractory Epilepsy-MRI, EEG and CT scan, a Correlative Clinical Study

Neuroimaging in Pediatric Epilepsy

Poster Presentations - Imaging Technologies and Informatics

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