Neuroimaging indicators of the performance of instrumental activities of daily living in <scp>A</scp>lzheimer's disease combined with cerebrovascular disease

Chen, Yang-Kun; Xiao, Weimin; Li, Wanyi; Liu, Yonglin; Li, Wei; Fang, Xue‐Wen; Weng, Han-Yu; Ungvári, Gábor S.; Xiang, Yu‐Tao

doi:10.1111/ggi.12323

Cited by 4 publications

(9 citation statements)

References 28 publications

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“…For example, Cahn et al ( 1996 ) found that in patients with depression, subcortical hyperintensities accounted for an additional 18 % of the variance in IADL, in addition to age, depression severity, and neuropsychological test performance. Similar results have been reported in other populations such as patients with vascular dementia (Boyle et al 2003b ), AD patients with cerebrovascular disease (Chen et al 2015 ), as well as in a longitudinal study in an elderly population (Inzitari et al 2007 ).…”

Section: Studies That Found Unique Associations With Neuroanatomical supporting

confidence: 86%

“… Only baseline EXEC independently predicted rate of decline in IADL scores. Chen et al 2015 . 66 AD patients with CVD (age 70.8 ± 10.7) IADL scale of Lawton and Brody Informant- report at follow-up Longitudinal, 6 months follow-up MMSE WML MTA VBR WML & MTA visual , VBR volumetric WML and MMSE significantly predicted IADL both at baseline and at follow-up.…”

Section: Resultsmentioning

confidence: 99%

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The Combined Effect of Neuropsychological and Neuropathological Deficits on Instrumental Activities of Daily Living in Older Adults: a Systematic Review

et al. 2016

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To date, studies have consistently demonstrated associations between either neuropsychological deficits or neuroanatomical changes and instrumental activities of daily living (IADL) in aging. Only a limited number of studies have evaluated morphological brain changes and neuropsychological test performance concurrently in relation to IADL in this population. As a result, it remains largely unknown whether these factors independently predict functional outcome. The current systematic review intended to address this lack of information by reviewing the literature on older adults, incorporating studies that examined e.g., normal aging, but also stroke or dementia patients. A comprehensive search of databases (Pubmed, Embase, Medline, Web of Science, PsycINFO) and reference lists was performed, focusing on papers in the English language that examined the combined effect of neuropsychological and neuroanatomical factors on IADL in samples of adults with an average age above 50. In total, 58 potential articles were identified; 20 were included in the review. The results show that especially neuropsychological variables (primarily memory and executive functions) independently predict IADL. Although some unique predictive value of brain morphological changes, such as hippocampal atrophy, was found, support for the importance of white matter changes was limited. However, the results of the studies reviewed are diverse, and appear to be at least partially determined by the variables included. For example, studies were less likely to find an independent effect of cognition if they solely employed a cognitive screening instrument. This indicates that a structured examination of neuroanatomical and neuropsychological correlates of IADL in different patient populations is warranted.Electronic supplementary materialThe online version of this article (doi:10.1007/s11065-015-9312-y) contains supplementary material, which is available to authorized users.

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Section: Studies That Found Unique Associations With Neuroanatomical supporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

The Combined Effect of Neuropsychological and Neuropathological Deficits on Instrumental Activities of Daily Living in Older Adults: a Systematic Review

et al. 2016

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“…WMH severity associates with cognitive decline, executive dysfunction, motor disturbance and depressive symptoms . Because the frontal lobes have a convergence of fiber pathways and play an important role in these functions, disruption in frontal tracts as a result of WMH easily lead to motor deterioration and cognitive decline that underlie impaired IADL performance …”

Section: Wmh and Geriatric Syndromementioning

confidence: 99%

“…79,80 Because the frontal lobes have a convergence of fiber pathways and play an important role in these functions, 60 disruption in frontal tracts as a result of WMH easily lead to motor deterioration and cognitive decline that underlie impaired IADL performance. 81,82…”

Section: Instrumental Adlmentioning

confidence: 99%

White matter hyperintensities and geriatric syndrome: An important role of arterial stiffness

Saji

Ogama

Toba

et al. 2015

Geriatrics Gerontology Int

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White matter hyperintensities (WMH) are defined as cerebral white matter changes presumed to be of vascular origin, bilateral and mostly symmetrical. They can appear as hyperintense on T2-weighted and fluid-attenuated inversion recovery sequences, and as isointense or hypointense on T1-weighted magnetic resonance imaging of the brain. WMH have been focused on because of their clinical importance as a risk factor for cerebrovascular diseases and cognitive impairment. WMH are associated with geriatric syndrome, which is defined by clinical symptoms characteristic of older adults, including cognitive and functional impairment and falls. Cerebral small vessel diseases, such as WMH, might play an important role as risk factors for cerebrovascular diseases, cognitive impairment and geriatric syndrome through the mechanism of arterial stiffness. However, the vascular, physiological and metabolic roles of arterial stiffness remain unclear. Basically, arterial stiffness indicates microvessel arteriosclerosis presenting with vascular endothelial dysfunction. These changes might arise from hemodynamic stress as a result of a "tsunami effect" on cerebral parenchyma. In the present article, we review the clinical characteristics of WMH, focusing particularly on two associations: (i) those between cerebral small vessel diseases including WMH and arterial stiffness; and (ii) those between WMH and geriatric syndrome. Geriatr Gerontol Int 2015; 15 (Suppl. 1): 17-25.

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“…Dementia is a decline in mental ability, caused by damage to brain cells, that interferes with daily life. Activities of daily living are usually divided into basic and instrumental activities of daily living (IADL) [1,2].…”

Section: Introductionmentioning

confidence: 99%

A physical model for dementia

Sotolongo‐Costa

Gaggero‐Sager

Becker

et al. 2017

Physica A: Statistical Mechanics and its Applications

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Aging associated brain decline often result in some kind of dementia. Even when this is a complex brain disorder a physical model can be used in order to describe its general behavior. A probabilistic model for the development of dementia is obtained and fitted to some experimental data obtained from the Alzheimer's Disease Neuroimaging Initiative. It is explained how dementia appears as a consequence of aging and why it is irreversible.

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Neuroimaging indicators of the performance of instrumental activities of daily living in Alzheimer's disease combined with cerebrovascular disease

Abstract: In patients with Alzheimer's disease combined with cerebrovascular disease, subcortical ischemic lesions might be significant contributor to the functional status.

Cited by 4 publications

References 28 publications

The Combined Effect of Neuropsychological and Neuropathological Deficits on Instrumental Activities of Daily Living in Older Adults: a Systematic Review

The Combined Effect of Neuropsychological and Neuropathological Deficits on Instrumental Activities of Daily Living in Older Adults: a Systematic Review

White matter hyperintensities and geriatric syndrome: An important role of arterial stiffness

A physical model for dementia

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