Neuroimaging of a novel mouse model of Alzheimer’s Disease: The hAβKI mouse.

Abstract

Mouse models of Alzheimer’s disease (AD) currently do not recapitulate accurately the human disease. The MODEL-AD consortium has recently developed new mouse models of AD, including the human amyloid β knockin (hAβKI) mouse. Using high resolution diffusion MRI (dMRI) we examined regional changes in the hAβKI male and female mouse across its lifespan (4-18mo). Sex and regional differences were apparent with age, including reduced diffusion metrics in the hippocampus, that mirrored altered learning and memory. Preclinical MR phenotyping allows for cross-species comparisons for biomarker identification.