Neuroimaging sex differences in emotional memory in schizophrenia patients

Lakis, Nadia; Jiménez, Javier; Marïë, Adham Mancini; Lavoie, Marc E.; Lupien, Sonia J.; Guillem, François; Stip, Émmanuel; Mendrek, Adrianna

doi:10.1097/01.yic.0000405843.25701.ca

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As in schizophrenic patients, it is common to find a reduced global activation in response to the unpleasant valence images, compared to neutral ones, during basic emotional tasks per se and during emotional memory tasks as well ( Schneider et al, 1998 ; Takahashi et al, 2004 ; Lakis et al, 2011a ). For instance, Lakis et al (2011b) showed that during a task of unpleasant image recognition, the cerebral activation was greater in the temporal and middle temporal gyrus, the precuneus, the cerebellum, the prefrontal cortex (orbitofrontal, upper and middle) and the cingulate gyrus in control individuals, while in schizophrenia patients exhibited significant activations only in the middle temporal cortex.…”

Section: Introductionmentioning

confidence: 99%

Event-related brain potentials to emotional images and gonadal steroid hormone levels in patients with schizophrenia and paired controls

Champagne¹,

Mendrek²,

Germain³

et al. 2014

Front. Psychol.

Self Cite

View full text Add to dashboard Cite

Prominent disturbances in the experience, expression, and emotion recognition in patients with schizophrenia have been relatively well documented over the last few years. Furthermore, sex differences in behavior and brain activity, associated with the processing of various emotions, have been reported in the general population and in schizophrenia patients. Others proposed that sex differences should be rather attributed to testosterone, which may play a role in the etiology of schizophrenia. Also, it had been suggested that estradiol may play a protective role in schizophrenia. Surprisingly, few studies investigating this pathology have focused on both brain substrates and gonadal steroid hormone levels, in emotional processing. In the present study, we investigated electrocortical responses related to emotional valence and arousal as well as gonadal steroid hormone levels in patients with schizophrenia. Event-Related Potentials (ERP) were recorded during exposition to emotional pictures in 18 patients with schizophrenia and in 24 control participants paired on intelligence, manual dominance and socioeconomic status. Given their previous sensitivity to emotional and attention processes, the P200, N200 and the P300 were selected for analysis. More precisely, emotional valence generally affects early components (N200), which reflect early process of selective attention, whereas emotional arousal and valence both influences the P300 component, which is related to memory context updating, and stimulus categorization. Results showed that, in the control group, the amplitude of the N200 was significantly more lateralized over the right hemisphere, while there was no such lateralization in patients with schizophrenia. In patients with schizophrenia, significantly smaller anterior P300 amplitude was observed to the unpleasant, compared to the pleasant. That anterior P300 reduction was also correlated with negative symptoms. The N200 and P300 amplitudes were positively correlated with the estradiol level in all conditions, revealing that the N200 and the P300 were reduced, when estradiol level was higher. Conversely, only the P300 amplitude showed positive correlation with the testosterone level.

show abstract