2016
DOI: 10.3389/fimmu.2016.00655
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Neuroimmune Interface in the Comorbidity between Alcohol Use Disorder and Major Depression

Abstract: Bidirectional communication links operate between the brain and the body. Afferent immune-to-brain signals are capable of inducing changes in mood and behavior. Chronic heavy alcohol drinking, typical of alcohol use disorder (AUD), is one such factor that provokes an immune response in the periphery that, by means of circulatory cytokines and other neuroimmune mediators, ultimately causes alterations in the brain function. Alcohol can also directly impact the immune functions of microglia, the resident immune … Show more

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Cited by 70 publications
(37 citation statements)
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“…Neuroinflammation has long been known as a pathophysiological process that is related to a number of neurodegenerative disorders, including Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, depression, and traumatic brain injury (Neupane, 2016; Piirainen et al., 2017; Sampson et al., 2016; Ullah et al., 2017; Xu et al., 2017). Neuroinflammation is triggered by activated and proliferating microglial cells, astrocytes, and other myeloid cells that ultimately produce pro‐inflammatory cytokines, chemokines, and other inflammatory mediators, leading to neuronal damage (Ullah et al., 2017; White, Lawrence, Brough & Rivers‐Auty, 2017).…”
Section: Introductionmentioning
confidence: 99%
“…Neuroinflammation has long been known as a pathophysiological process that is related to a number of neurodegenerative disorders, including Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, depression, and traumatic brain injury (Neupane, 2016; Piirainen et al., 2017; Sampson et al., 2016; Ullah et al., 2017; Xu et al., 2017). Neuroinflammation is triggered by activated and proliferating microglial cells, astrocytes, and other myeloid cells that ultimately produce pro‐inflammatory cytokines, chemokines, and other inflammatory mediators, leading to neuronal damage (Ullah et al., 2017; White, Lawrence, Brough & Rivers‐Auty, 2017).…”
Section: Introductionmentioning
confidence: 99%
“…First, there is evidence that AUD leads to dysfunction in a number of the biologic systems for which CBD has favorable effects. For example, alcohol is a potent modulator of the immune system, potentiating alcohol‐induced liver inflammation and stimulating immune cells, like monocytes, macrophages, and T lymphocytes, which in turn cause the release of proinflammatory cytokines (reviewed in Neupane, ). To address these effects, CBD's anti‐inflammatory effects may prove beneficial.…”
mentioning
confidence: 99%
“…Peripheral inflammation is known to play a role in mental health as we and others have described [1, 7, 42, 43]. Inflammation-induced mental dysfunction is most clearly observed in conditions such as cancer or hepatitis, where patients are treated with a pro-inflammatory mediator such as interferon-α [42, 4446], and, more recently, in the context of substance use disorders [1, 47, 48]. Thus, reduced CCL3 may lead to slower wound healing, thereby resulting in persistent infection and a prolonged period of inflammatory signaling, which may result in ongoing symptoms of depression, anxiety and memory impairment.…”
Section: Discussionmentioning
confidence: 99%