Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders

Kondo, Takeshi; Okada, Yuka; Shizuya, Saika; Yamaguchi, Naoko; Hatakeyama, Shigetsugu; Maruyama, Kenta

doi:10.1016/j.ejcb.2024.151418

European Journal of Cell Biology

2024

DOI: 10.1016/j.ejcb.2024.151418

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Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders

Takeshi Kondo,

Yuka Okada,

Saika Shizuya

et al.

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2024

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Cited by 4 publications

References 396 publications

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Metabolomics reveals the metabolic disturbance caused by arsenic in the mouse model of inflammatory bowel disease

Wu,

Wang,

Lin

et al. 2024

Ecotoxicology and Environmental Safety

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Metabolomics reveals the metabolic disturbance caused by arsenic in the mouse model of inflammatory bowel disease

Wu,

Wang,

Lin

et al. 2024

Ecotoxicology and Environmental Safety

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Novel machine learning investigation for Buongiorno fluidic model with Sutterby nanomaterial

Khan,

Chang,

Raja

et al. 2024

Tribology International

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Reverse engineering the Gut-Brain Axis and microbiome-metabolomics for symbiotic/pathogenic balance in neurodegenerative diseases

Munir,

Ali,

Chung

et al. 2024

Gut Microbes

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Deciphering the molecular communications along the gut-brain axis can help in understanding the pathophysiology of neurodegenerative diseases and exploiting the gut microbiome for therapeutics. However, gut microbes and their metabolites have a multifaceted role in mediating both brain physiology and neurodegenerative pathology. There is a lack of understanding of how and when this role is tipped in neurodegenerative diseases and what are those contributing factors, both at local (gut) and distal (neuronal) levels, that drive this imbalance. Here we have reviewed the gut microbiome and its metabolites in the context of the gut-brain axis and summarized how different factors such as gut-microbial diversity, their metabolites, the role of the native immune system and the integrity of gut epithelial and blood-brain barriers are interconnected and collectively define the involvement of gut-microbiome in neurodegenerative pathologies. It also underlines the need for multidisciplinary tools and animal models to simultaneously reflect on many of these factors and to better correlate with clinical observations and data obtained from human biopsies and fecal samples. Harnessing the gut-brain axis will herald a paradigm shift in medicine for neurodegenerative diseases and aging, emphasizing the significance of the microbiome in the broader spectrum of health and disease.

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Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders

Cited by 4 publications

References 396 publications

Metabolomics reveals the metabolic disturbance caused by arsenic in the mouse model of inflammatory bowel disease

Metabolomics reveals the metabolic disturbance caused by arsenic in the mouse model of inflammatory bowel disease

Novel machine learning investigation for Buongiorno fluidic model with Sutterby nanomaterial

Reverse engineering the Gut-Brain Axis and microbiome-metabolomics for symbiotic/pathogenic balance in neurodegenerative diseases

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