Neuroinflammation and anti-inflammatory therapy for Alzheimer’s disease

Moore, Amy H.; O’Banion, M. Kerry

doi:10.1016/s0169-409x(02)00162-x

Cited by 128 publications

(76 citation statements)

References 319 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, increased neuroinflammation and oxidative stress can perturb the proper function of brain neurons, they can impede the efficiency of long term potentiation required for new memory formation, they can amplify the production and potentiate the effects of the Ab protein. Since evidence emerged that non-steroidal anti-inflammatory drugs may be effective in delaying the onset of neurodegenerative disorders (Moore and O'Banion, 2002), there has been much interest in the development of new drugs capable of preventing neuroinflammatory mediated brain injury. Over the last years, efforts have been made at investigating the effect polyphenols on neuroinflammation.…”

Section: Polyphenols Mitigate Neuroinflammationmentioning

confidence: 99%

Polyphenols and brain health

Vauzour

2017

OCL

View full text Add to dashboard Cite

-Accumulating evidence suggests that diet and lifestyle can play an important role in delaying the onset or halting the progression of age-related health disorders and to improve cognitive function. A growing number of dietary intervention studies in humans and animals and in particular those using polyphenol-rich diets have been proposed to exert a multiplicity of neuroprotective actions within the brain, including a potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation and a potential to promote memory, learning, and cognitive functions. These effects appear to be underpinned by two common processes. First, they are capable of interactions with critical protein and lipid kinase signalling cascades in the brain, leading to an inhibition of apoptosis triggered by neurotoxic species and to a promotion of neuronal survival and synaptic plasticity. Second, they induce beneficial effects on the vascular system, leading to changes in cerebrovascular blood flow capable of causing enhance vascularisation and neurogenesis, two events important in the maintenance of cognitive performances. Together, these processes act to maintain brain homeostasis and play important roles in neuronal stress adaptation and thus polyphenols might have the potential to prevent the progression of neurodegenerative pathologies.

show abstract

Section: Polyphenols Mitigate Neuroinflammationmentioning

confidence: 99%

Polyphenols and brain health

Vauzour

2017

OCL

View full text Add to dashboard Cite

show abstract

“…Neuroinflammation has also been implicated in the neuropathogenesis of dementia. In dementia patients neuroinflammation is often combined with -amyloid peptide accumulation and neurofibrillary tangles development (Moore, O'Banion 2002). Neuronal cells in the hippocampus are peculiarly vulnerable to the influence of chronic inflammation (HaussWengrzyniak et al, 2000;Wenk, Barnes 2000).…”

Section: Neuroinflammation After Ischemiamentioning

confidence: 99%

“…This activity may lead to significant progression of brain ischemia cases through neurons loss. Epidemiological studies suggest that long use of anti-inflammatory treatment in amyloid and neuroinflammatory disease like Alzheimer's disease can prevent its development (Moore, O'Banion 2002;Szekely et al, 2004). From these observations considerable studies were undertaken to investigate the influence of anti-inflammation treatment in ischemic and amyloid brain diseases.…”

Section: Suppressing Neuroinflammationmentioning

confidence: 99%

“…In this way a novel and more effective therapy approaches www.intechopen.com can be formulated and more data on different kind amyloidosis can be gathered. Aforementioned data suggest that reducing movement of -amyloid peptide from blood to brain tissue (Dickstein et al, 2006) and significantly improving reverse transport from brain into blood plasma ) and preventing ischemic events in neurons (Pluta 2007c see for references) are principal main future points in treatment of ischemic brain injury (Iwata et al, 2001;Moore, O'Banion 2002;Cheng et al, 2003;Deane et al, 2003;Borlongan et al, 2004;Deane et al, 2004a;Deane et al, 2004b;Guo et al, 2004;Kalback et al, 2004;Koistinaho et al, 2004;Tanzi et al, 2004;Pluta, Ulamek 2008]. Current data provide new information that injection with -amyloid peptide reduces blood-brain barrier leakage, amyloid burden and microgliosis in transgenic model of amyloid pathology (Dickstein et al, 2006).…”

Section: Protecting Blood-brain Barriermentioning

confidence: 99%

See 1 more Smart Citation

Alzheimer's Factors in Ischemic Brain Injury

Pluta¹,

Jabłoński²

2012

Brain Injury - Pathogenesis, Monitoring, Recovery and Management

View full text Add to dashboard Cite

“…Mais recentemente, inúmeros estudos têm sido publicados questionando a terapia antiinflamatória, principalmente utilizando-se drogas não-esteroidais, como tratamento para a neuroinflamação ocasionada pelas ROS e espécies reativas de nitrogênio (RNS) e pela formação de radicais livres associados à doença de Alzheimer 35 .…”

Section: A Inflamação Na Doença De Alzheimerunclassified

A doença de Alzheimer: aspectos fisiopatológicos e farmacológicos

Sereniki¹,

Vital

2008

Rev. psiquiatr. Rio Gd. Sul

113

View full text Add to dashboard Cite

Endereço para correspondênciaRev Psiquiatr RS. 2008;30(1 Supl). RESUMOA doença de Alzheimer é a patologia neurodegenerativa mais freqüente associada à idade, cujas manifestações cognitivas e neuropsiquiátricas resultam em deficiência progressiva e incapacitação. A doença afeta aproximadamente 10% dos indivíduos com idade superior a 65 anos e 40% acima de 80 anos. Estima-se que, em 2050, mais de 25% da população mundial será idosa, aumentando, assim, a prevalência da doença. O sintoma inicial da doença é caracterizado pela perda progressiva da memória recente. Com a evolução da patologia, outras alterações ocorrem na memória e na cognição, entre elas as deficiências de linguagem e nas funções vísuo-espaciais. Esses sintomas são freqüentemente acompanhados por distúrbios comportamentais, incluindo agressividade, depressão e alucinações. O objetivo deste trabalho foi revisar, na literatura médica, os principais aspectos que envolvem a doença de Alzheimer, como as características histopatológicas, a neuroinflamação e a farmacoterapia atual.Descritores: Doença de Alzheimer, inflamação, acetilcolinesterase, inibidores de ciclooxigenase. ABSTRACTAlzheimer's disease is the most frequent age-associated neurodegenerative disease. Its

show abstract

Neuroinflammation and anti-inflammatory therapy for Alzheimer’s disease

Cited by 128 publications

References 319 publications

Polyphenols and brain health

Polyphenols and brain health

Alzheimer's Factors in Ischemic Brain Injury

A doença de Alzheimer: aspectos fisiopatológicos e farmacológicos

Contact Info

Product

Resources

About