Neuroinflammation and Brain Disease

Bersano, Anna; Engele, Jürgen; Schäfer, M.K.E.

doi:10.1186/s12883-023-03252-0

Cited by 13 publications

(6 citation statements)

References 24 publications

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“…In addition, neuroinflammation contributes to the onset and progression of neurodegenerative diseases [ 138 ]. A common feature of these diseases is reduced hippocampal neurogenesis [ 139 ], which is poorly understood.…”

Section: Cannabinoids In Central Immunity and Neurodegenerative Diseasesmentioning

confidence: 99%

Cannabinoids’ Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases

Sharon,

Yarmolinsky,

Khalfin

et al. 2024

IJMS

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Cannabinoids (the endocannabinoids, the synthetic cannabinoids, and the phytocannabinoids) are well known for their various pharmacological properties, including neuroprotective and anti-inflammatory features, which are fundamentally important for the treatment of neurodegenerative diseases. The aging of the global population is causing an increase in these diseases that require the development of effective drugs to be even more urgent. Taking into account the unavailability of effective drugs for neurodegenerative diseases, it seems appropriate to consider the role of cannabinoids in the treatment of these diseases. To our knowledge, few reviews are devoted to cannabinoids’ impact on modulating central and peripheral immunity in neurodegenerative diseases. The objective of this review is to provide the best possible information about the cannabinoid receptors and immuno-modulation features, peripheral immune modulation by cannabinoids, cannabinoid-based therapies for the treatment of neurological disorders, and the future development prospects of making cannabinoids versatile tools in the pursuit of effective drugs.

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Section: Cannabinoids In Central Immunity and Neurodegenerative Diseasesmentioning

confidence: 99%

Cannabinoids’ Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases

Sharon,

Yarmolinsky,

Khalfin

et al. 2024

IJMS

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“…The common pathological aspect of these brain injuries is the occurrence of neuroinflammation (Jayaraj et al, 2019;Morganti-Kossmann et al, 2019). The released damage-associated molecular patterns (DAMPs) of dying cells trigger robust inflammatory responses within the brain that damage the BBB and lead to the infiltration of peripheral immune cells, such as neutrophils, monocytes/macrophages and T cells (Zhang Z. et al, 2022;Bersano et al, 2023). The role of CD8 + T cells in brain injury is being discovered.…”

Section: Cd8 + T Cells In Brain Injurymentioning

confidence: 99%

CD8+ T cells in brain injury and neurodegeneration

Zhang,

Duan,

Cui

2023

Front. Cell. Neurosci.

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The interaction between the peripheral immune system and the brain is increasingly being recognized as an important layer of neuroimmune regulation and plays vital roles in brain homeostasis as well as neurological disorders. As an important population of T-cell lymphocytes, the roles of CD8+ T cells in infectious diseases and tumor immunity have been well established. Recently, increasing number of complex functions of CD8+ T cells in brain disorders have been revealed. However, an advanced summary and discussion of the functions and mechanisms of CD8+ T cells in brain injury and neurodegeneration are still lacking. Here, we described the differentiation and function of CD8+ T cells, reviewed the involvement of CD8+ T cells in the regulation of brain injury including stroke and traumatic brain injury and neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), and discussed therapeutic prospects and future study goals. Understanding these processes will promote the investigation of T-cell immunity in brain disorders and provide new intervention strategies for the treatment of brain injury and neurodegeneration.

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“…Indeed, pathogenic as well as protective effects of B cells have been reported in the context of neurological and spinal cord injuries ( Engler-Chiurazzi et al, 2020 ; Plantone et al, 2022 ; Maheshwari et al, 2023 ; Malone et al, 2023 ), autoimmune diseases ( Jain and Yong, 2022 ), and brain aging, neurodegeneration, and dementia ( Plantone et al, 2022 ), to name just a few examples. Neuroinflammation is a shared feature of many of the neurological diseases in which B cells are implicated ( Bersano et al, 2023 ). And yet, while systemic and neuroinflammation is being increasingly linked to the response to psychosocial stress and the manifestation of chronic stress-related conditions ( Maes, 2011 ; Wohleb et al, 2016 ; Herkenham and Kigar, 2017 ; Dantzer, 2018 ), the role of the B cell in this context is not well understood.…”

Section: Introductionmentioning

confidence: 99%

B cells and the stressed brain: emerging evidence of neuroimmune interactions in the context of psychosocial stress and major depression

Engler-Chiurazzi

2024

Front. Cell. Neurosci.

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The immune system has emerged as a key regulator of central nervous system (CNS) function in health and in disease. Importantly, improved understanding of immune contributions to mood disorders has provided novel opportunities for the treatment of debilitating stress-related mental health conditions such as major depressive disorder (MDD). Yet, the impact to, and involvement of, B lymphocytes in the response to stress is not well-understood, leaving a fundamental gap in our knowledge underlying the immune theory of depression. Several emerging clinical and preclinical findings highlight pronounced consequences for B cells in stress and MDD and may indicate key roles for B cells in modulating mood. This review will describe the clinical and foundational observations implicating B cell-psychological stress interactions, discuss potential mechanisms by which B cells may impact brain function in the context of stress and mood disorders, describe research tools that support the investigation of their neurobiological impacts, and highlight remaining research questions. The goal here is for this discussion to illuminate both the scope and limitations of our current understanding regarding the role of B cells, stress, mood, and depression.

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Neuroinflammation and Brain Disease

Cited by 13 publications

References 24 publications

Cannabinoids’ Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases

Cannabinoids’ Role in Modulating Central and Peripheral Immunity in Neurodegenerative Diseases

CD8+ T cells in brain injury and neurodegeneration

B cells and the stressed brain: emerging evidence of neuroimmune interactions in the context of psychosocial stress and major depression

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