Neuroinflammation in Huntington’s Disease

Lee, John D.; Lo, Martin W; Fung, J.; Woodruff, Trent M.

doi:10.1007/978-1-0716-1712-0_9

Cited by 1 publication

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“…These myelination deficits likely impair the transmission of information across neuronal circuits, as seen by motor performance impairments in mice expressing mHTT specifically in oligodendroglia cells and the rescue of various HD-related pathologies when it is genetically excised from HD mice ( 24 , 27 , 31 ). While the functional roles of microglia, astrocytes, and oligodendrocytes in HD progression have been extensively reviewed ( 32 , 33 ), emerging evidence suggests sex differences in these glial cells may impact neurodegenerative disease outcomes. Here, we focus on the sex-specific role of these cells in HD progression, a topic that has not been extensively discussed previously ( Figure 1 ).…”

Section: Neuroinflammation In Hdmentioning

confidence: 99%

Sex differences in Huntington's disease from a neuroinflammation perspective

Risby-Jones,

Lee,

Woodruff

et al. 2024

Front. Neurol.

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Huntington's disease (HD) is a debilitating neurodegenerative condition characterized by motor, cognitive and psychiatric abnormalities. Immune dysregulation, prominently featuring increased immune activity, plays a significant role in HD pathogenesis. In addition to the central nervous system (CNS), systemic innate immune activation and inflammation are observed in HD patients, exacerbating the effects of the Huntingtin (HTT) gene mutation. Recent attention to sex differences in HD symptom severity underscores the need to consider gender as a biological variable in neurodegenerative disease research. Understanding sex-specific immune responses holds promise for elucidating HD pathophysiology and informing targeted treatment strategies to mitigate cognitive and functional decline. This perspective will highlight the importance of investigating gender influence in HD, particularly focusing on sex-specific immune responses predisposing individuals to disease.

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