Neurointerface with Oscillator Motifs for inhibitory effect over antagonist muscles for compensation of spastical syndrome

Abstract

The inhibitory management effect is usually un- derestimated in artificial control systems, using biological anal- ogy. According to our hypothesis, the muscle hypertonus could be effectively compensated via stimulation by bio plausible patterns. We proposed the approach for the compensatory stimulation device in development of previously presented archi- tecture of neurointerface, where (1) neuroport is implemented as DAC and stimulator, (2) neuroterminal – as neurosimulation of a set of oscillator motifs on one-board computer. In the set of experiments with 5 volunteers we measured the efficacy of motor neuron inhibition via antagonist muscle or nerve stim- ulation registering muscle force with and without antagonist stimulation. For the agonist activation, we used both voluntary activity and electrical stimulation. In the case of stimulation of both agonist and antagonist muscles and nerves, we exper- imented with delays between muscles stimulation starts in the range 0...20 ms. We registered the subjective discomfort rate. We didn’t identify a significant difference between antagonist muscle and nerve stimulation in both voluntary and stimulation of agonist activity. We determined the most effective delay between stimulation of agonist and antagonist muscle/nerve as 10–20 ms.

Memristive circuit-based model of central pattern generator to reproduce spinal neuronal activity in walking pattern

“…Recently, we published works introducing a computational bio-compatible approach incorporating Oscillator Motif (OM)-the basic neuronal generator (Leukhin et al, 2020;Talanov et al, 2020). Later, we extended the use of OMs for the neurointerfaces (Talanov et al, 2021) and spasticity compensating devices (Mikhailova et al, 2022).…”