Neuroinvasive influenza virus A(H5N8) in fattening ducks, Hungary, 2015

Bányai, Krisztiàn; Bistyák, A.; Thuma, Ákos; Eva, Gudumac; Ursu, Krisztina; Marton, Szilvia; Farkas, Szilvia L.; Eleonóra, Hortobágyi; Bacsadi, Á.; Dán, Ádám

doi:10.1016/j.meegid.2016.05.027

Cited by 19 publications

(25 citation statements)

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“…Although the outbreaks in 2014 and 2016 were caused by different subtypes of H5Nx, the clinical signs were not notably different over the years in Pekin ducks. The observation of neurological signs (mainly head tremors, torticollis and ataxia) in our study in Pekin ducks is in line with findings reported in an outbreak of H5N8 among fattening Pekin ducks in Hungary in 2015 (Bányai et al., 2016) where affected ducks showed neurologic signs, including torticollis. These findings are further supported with the results of studies where Pekin ducks were infected experimentally with different H5Nx subtypes of clade 2.3.4.4 (Sun et al., 2016).…”

Section: Discussionsupporting

confidence: 92%

Highly pathogenic avian influenza subtype H5Nx clade 2.3.4.4 outbreaks in Dutch poultry farms, 2014–2018: Clinical signs and mortality

Schreuder

Manders

Elbers

et al. 2020

Transbound Emerg Dis

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Section: Discussionsupporting

confidence: 92%

Highly pathogenic avian influenza subtype H5Nx clade 2.3.4.4 outbreaks in Dutch poultry farms, 2014–2018: Clinical signs and mortality

Schreuder

Manders

Elbers

et al. 2020

Transbound Emerg Dis

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“…In 2016, outbreaks in poultry holdings were reported from Austria, Denmark, France, Germany, Hungary, the Netherlands, Poland and Sweden [ 2 ]. This resembles the situation in the northern hemisphere winter 2014/15 when a virus of the same clade 2.3.4.4 caused outbreaks in six European countries (Germany [ 3 , 4 ], Italy [ 5 ], Hungary [ 6 ], the Netherlands [ 7 ], Sweden and the United Kingdom [ 8 ]), mainly in closed poultry holdings, and sporadic detections in wild birds and a zoo [ 2 , 3 ]. Although the viruses belong to the same genotype clade, viruses during the 2014/15 outbreak belonged to a different group of clade 2.3.4.4, group A (Buan-like), while the current 2016 viruses cluster in clade 2.3.4.4 group B (Gochang-like).…”

Section: Avian Influenza A(h5n8) Situation In Europe December 2016mentioning

confidence: 61%

Highly pathogenic avian influenza A(H5N8) outbreaks: protection and management of exposed people in Europe, 2014/15 and 2016

et al. 2016

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Introduction of highly pathogenic avian influenza (HPAI) virus A(H5N8) into Europe prompted animal and human health experts to implement protective measures to prevent transmission to humans. We describe the situation in 2016 and list public health measures and recommendations in place. We summarise critical interfaces identified during the A(H5N1) and A(H5N8) outbreaks in 2014/15. Rapid exchange of information between the animal and human health sectors is critical for a timely, effective and efficient response.

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“…Grossly, congestion of the lung, spleen and liver, and congestion and oedema of the subcutaneous tissue of the head and the meninges were observed. Moreover, haemorrhage and necrosis in the pancreas and focal haemorrhages under the epicardium were detected (Banyai et al, 2016). Similar lesions were induced by HPAI H5N1 infection in wild tufted ducks (Aythyafuligula) (Brojer et al, 2009).…”

Section: Introductionmentioning

confidence: 61%

Characterization of highly pathogenic avian influenza H5N8 virus from Egyptian domestic waterfowl in 2017

2018

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In 2016, the highly pathogenic avian influenza (HPAI) H5N8 virus was detected in wild birds for the first time in Egypt. In the present study, we identified the HPAI virus H5N8 of clade 2.3.4.4 from domestic waterfowl in Egypt, suggesting its transmission to the domestic poultry from the migratory birds. Based on partial haemagglutinin gene sequence, this virus has a close genetic relationship with subtype H5N8 viruses circulating in Asia and Europe. Pathologically, H5N8 virus in hybrid duck induced nervous signs accompanied by encephalomalacia, haemorrhages, nonsuppurative encephalitis and nonsuppurative vasculitis. The granular layer of cerebellum showed multifocal areas of hydropic degeneration and the Purkinje cell neurons were necrotized or lost. Additionally, the lung, kidney and spleen were congested, and necrotizing pancreatitis was also observed. The co-circulation of both HPAI H5N1 and H5N8 subtypes with the low pathogenic avian influenza H9N2 subtype complicate the control of avian influenza in Egypt with the possibility of emergence of new reassortant viruses. Therefore, continuous monitoring with implementation of strict control measures is required. Research highlights HPAI H5N8 virus clade 2.3.4.4 was detected in domestic ducks and geese in Egypt in 2017. Phylogenetically, the virus was closely related to HPAI H5N8 viruses identified in Asia and Europe Nonsuppurative encephalitis was widely observed in HPAI H5N8 virus-infected ducks. Degeneration of the cerebellar granular layer was found in most of the brain tissues examined.

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Neuroinvasive influenza virus A(H5N8) in fattening ducks, Hungary, 2015

Cited by 19 publications

References 20 publications

Highly pathogenic avian influenza subtype H5Nx clade 2.3.4.4 outbreaks in Dutch poultry farms, 2014–2018: Clinical signs and mortality

Highly pathogenic avian influenza subtype H5Nx clade 2.3.4.4 outbreaks in Dutch poultry farms, 2014–2018: Clinical signs and mortality

Highly pathogenic avian influenza A(H5N8) outbreaks: protection and management of exposed people in Europe, 2014/15 and 2016

Characterization of highly pathogenic avian influenza H5N8 virus from Egyptian domestic waterfowl in 2017

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