2020
DOI: 10.1186/s12974-020-01929-8
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Neuroinvasive Listeria monocytogenes infection triggers accumulation of brain CD8+ tissue-resident memory T cells in a miR-155-dependent fashion

Abstract: Background: Brain inflammation is a key cause of cognitive decline after central nervous system (CNS) infections. A thorough understanding of immune responses to CNS infection is essential for developing anti-inflammatory interventions that improve outcomes. Tissue-resident memory T cells (T RM) are non-recirculating memory T cells that provide surveillance of previously infected tissues. However, in addition to protecting the brain against reinfection, brain T RM can contribute to post-infectious neuroinflamm… Show more

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Cited by 13 publications
(27 citation statements)
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“…The weight loss is considered a key biological feature of sepsis in mouse models (Stortz et al, 2019) and the time course of changes in body weight associated with L. monocytogenes induced sepsis is shown in Figure 1B. The weight loss in current project was similar to reported data that previously utilized similar sepsis model (Cassidy et al, 2020). The timescale of observed mortality and weight loss in our sepsis model was also similar to sepsis timescale in humans, when the vast majority of deaths in first 72 h after admission to the ICU are due to primary infection-related multiple organ failure (Daviaud et al, 2015).…”
Section: Sepsis On Mortality Rates and Body Weights In Aged Micesupporting
confidence: 80%
See 1 more Smart Citation
“…The weight loss is considered a key biological feature of sepsis in mouse models (Stortz et al, 2019) and the time course of changes in body weight associated with L. monocytogenes induced sepsis is shown in Figure 1B. The weight loss in current project was similar to reported data that previously utilized similar sepsis model (Cassidy et al, 2020). The timescale of observed mortality and weight loss in our sepsis model was also similar to sepsis timescale in humans, when the vast majority of deaths in first 72 h after admission to the ICU are due to primary infection-related multiple organ failure (Daviaud et al, 2015).…”
Section: Sepsis On Mortality Rates and Body Weights In Aged Micesupporting
confidence: 80%
“…or i.p. injections are commonly used to bypass the GI tract in mice and to establish systemic infection in a reproducible fashion (Zhang et al, 2018;Cassidy et al, 2020).…”
Section: Sepsis Model and Experimental Animalsmentioning
confidence: 99%
“…For example, microRNA-155 is upregulated during infection in response to TLR signaling and inflammatory cytokines ( 123 ). CD8 + T RM are established in the brain following infection of mice with neuroinvasive LM, and their accumulation is decreased in the absence of miR-155 ( 124 ). Also, CD8 + T cells require P2RX7 expression for CD8 + T RM formation in the siIEL, female reproductive tract, kidney, salivary glands, and liver.…”
Section: Stage 2: Mechanisms That Encourage Cd8 + T Rm To Settle In Peripheral Tissuesmentioning
confidence: 99%
“…Most populations of recruited leukocytes return to pre-infection levels after the infection is cleared [ 7 ]. However, elevated numbers of CD8 + tissue-resident memory cells (T RM ) remain in the brain after CNS infection with bacteria, protozoans, and viruses [ 8 12 ]. These long-lived, non-recirculating T-lymphocytes also accumulate in the brain during to non-infectious conditions such Alzheimer’s disease and multiple sclerosis, as well as during normative aging [ 13 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…To study long-term inflammatory changes in the brain, we previously adapted the mouse model by treating Lm -infected animals, which would otherwise die of infection, with the same antibiotic used in humans [ 6 , 19 ]. We identified significantly increased numbers of CD8 + bT RM 28 days after neuroinvasive Lm infection in young mice [ 8 ]. These cells were extravascular and had a CD3 + CD8 + CD44 + CD62L − CD69 + CX3CR1 − phenotype characteristic of T RM .…”
Section: Introductionmentioning
confidence: 99%