Neurokinin-3 receptors modulate dopamine cell function and alter the effects of 6-hydroxydopamine

Bannon, Michael J.; Brownschidle, Lisa A.; Tian, Ye; Whitty, Christopher J. M.; Poosch, Michael S.; D’Sa, Carrol; Moody, Carole A.

doi:10.1016/0006-8993(95)00791-n

Cited by 37 publications

(27 citation statements)

References 34 publications

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“…NK3 receptors have been demonstrated on dopaminergic neurons in the substantia nigra (SN) and ventral tegmental area (VTA) (Stoessl 1994;Langlois et al 2001). Activation of this receptor modulates the release of dopamine (Stoessl et al 1991;Bannon et al 1995). Senktide, a NK3 receptor agonist, has also been shown to excite dopaminergic neurons in the SN and VTA (Keegan et al 1992;Seabrook et al 1995).…”

Section: Discussionmentioning

confidence: 97%

“…Based on these data, localization studies, and the pharmacological effects of tachykinin ligands, the NK3 receptor has been suggested to play a role in schizophrenia (Meltzer and Prus 2006), Parkinson's disease (Bannon et al 1995;Chen et al 2004), epilepsy (Roder et al 1994), anxiety (Ribeiro et al 1999;Hasenohrl et al 2000), depression (Panocka et al 2001), and memory and reinforcement related processes Huston et al 1993;Krappmann et al 1994).…”

Section: Introductionmentioning

confidence: 98%

“…The physiological role of NK3 receptors in the mammalian CNS is unknown, although a number of studies have reported that the activation of this receptor modulates the release of several neurotransmitters including 5-HT ), acetylcholine (Arenas et al 1991;Boix et al 1994;Steinberg et al 1995;De Souza Silva et al 2000), dopamine (Boix et al 1992;Stoessl et al 1991;Bannon et al 1995), and vasopressin (Saigo et al 1993). Based on these data, localization studies, and the pharmacological effects of tachykinin ligands, the NK3 receptor has been suggested to play a role in schizophrenia (Meltzer and Prus 2006), Parkinson's disease (Bannon et al 1995;Chen et al 2004), epilepsy (Roder et al 1994), anxiety (Ribeiro et al 1999;Hasenohrl et al 2000), depression (Panocka et al 2001), and memory and reinforcement related processes Huston et al 1993;Krappmann et al 1994).…”

Section: Introductionmentioning

confidence: 98%

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Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits

et al. 2007

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

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Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits

et al. 2007

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“…7 The soluble carrier family six dopamine transporter member three gene (DAT, locus symbol: SLC6A3) codes for a dopamine transporter protein (DAT), which limits the level and duration of dopamine receptor activation. 8 The mouse model of dopamine transporter gene knockout established not only the central importance of dopamine transporter in controlling synaptic dopamine levels, but also its role as an obligatory target for the behavioral and biochemical action of amphetamine and cocaine. 9 Vandenbergh et al 10 identified several polymorphisms in DAT1, including a polymorphic 40 bp repeat in the transcribed portion of the gene, which is most commonly observed repeat 9 (DAT1*9R) to 10 times (DAT1*10R).…”

Section: Introductionmentioning

confidence: 99%

Dopamine transporter, gender, and number of sexual partners among young adults

et al. 2007

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The dopamine transporter gene (DAT1) codes for a dopamine transporter protein, which limits the level and duration of dopamine receptor activation. The DAT1 gene is a strong candidate gene for rewardseeking behavior. This article reports compelling evidence for the association between the 40 bp variable number of tandem repeats in the DAT1 gene and the self-reported number of sexual partners among young adults in the United States using the sibling subsample of more than 2500 individuals who participated in the National Longitudinal Study of Adolescent Health. We performed tests of genotypegender interaction as well as analyses stratified by gender. Among the males, possessing one or two alleles of the 10 repeat is associated with an 80-100% increase (Po0.0001, 2df) in the number of sexual partners as compared with the homozygotes for the 9 repeat. The association holds in race/ethnicity-stratified analyses, in Allison's procedure that tests population stratification, and in within-family fixed-effects models. Covariate adjustment for a standard set of socioeconomic factors including religiosity, family structure, parental education, marital and cohabitation history, and neighborhood poverty did not attenuate these associations. Discussion is provided why this finding is absent among females.

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“…Compared with the NK 1 and NK 2 receptors, much less is known about the biological function of the NK 3 receptor. NK 3 receptors are mainly distributed in the central nervous system (4), and NKB has the highest affinity to this receptor subtype. With the recent development of selective NK 3 antagonists (5,6), it is expected that the biological function of the NK 3 receptor will be elucidated in the near future.…”

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confidence: 99%

The Unpredicted High Affinities of a Large Number of Naturally Occurring Tachykinins for Chimeric NK1/NK3 Receptors Suggest a Role for an Inhibitory Domain in Determining Receptor Specificity

Tian¹,

Wu²,

Oxender³

et al. 1996

Journal of Biological Chemistry

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Three chimeric receptors were constructed by exchanging exon sequences between human NK 1 and NK 3 receptor genes. The resulting chimeric receptors not only retained high affinities for their natural ligands substance P and neurokinin B but also exhibited surprisingly high affinities for other naturally occurring tachykinins including neurokinin A, neuropeptide K, neuropeptide ␥, eledoisin, kassinin, physalaemin, and phyllomedusin. In contrast, these chimeric receptors displayed a wide range of variability in their affinities for non-naturally occurring ligands including selective agonists and antagonists of NK 1 , NK 2 , and NK 3 receptors. Since the only common feature among these naturally occurring neurokinin peptides is the conserved C-terminal sequences, our data suggest that these conserved sequences must play the major role in conferring high affinity binding to the chimeric receptors. To explain the apparently "improved" affinities of these naturally occurring ligands for the chimeric receptors as compared with their affinities for the parent NK 1 and NK3 receptors, we are proposing that certain inhibitory domains that are present in the NK 1 and/or NK 3 receptors are compromised in these chimeric receptors. Upon disruption of these inhibitory domains during the formation of chimeras, the naturally occurring ligands can interact more favorably with chimeric receptors through their conserved C-terminal sequences. Based on this hypothesis, the binding affinities of natural tachykinin ligands may be largely determined by their conserved C-terminal sequences, whereas receptor selectivities of these ligands are influenced more by the presence or absence of inhibitory domains rather than specific binding domains on their target receptors.

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Neurokinin-3 receptors modulate dopamine cell function and alter the effects of 6-hydroxydopamine

Cited by 37 publications

References 34 publications

Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits

Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits

Dopamine transporter, gender, and number of sexual partners among young adults

The Unpredicted High Affinities of a Large Number of Naturally Occurring Tachykinins for Chimeric NK1/NK3 Receptors Suggest a Role for an Inhibitory Domain in Determining Receptor Specificity

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