Neurokinin A in the parotid and submandibular glands of the rat: immunohistochemical localization and effect on protein and peroxidase secretion

Virta, Erkki; Kangas, S.; Tolonen, R; Schultz, Troy; Salo, Antero; Uusitalo, Hannu

doi:10.1111/j.1748-1716.1991.tb09143.x

Cited by 14 publications

(2 citation statements)

References 33 publications

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“…It has been shown that substance P, VIP, and neurokinin A all have a stimulatory effect on salivary secretion (Lundberg et al, 1980;Ekstr6m, 1987;Virta et al, 1991). Currently, there are limited physiological data on the effects of NPY in the salivary glands.…”

Section: Parasympathetic Npy-fibresmentioning

confidence: 99%

The sympathetic and parasympathetic nature of neuropeptide Y-immunoreactive nerve fibres in the major salivary glands of the rat

et al. 1994

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The distribution and origin of neuropeptide Y in the major salivary glands of the rat was studied by indirect immunofluorescence technique. Numerous nerve fibres immunoreactive for the peptide were seen in the parotid and sublingual glands. Most of the fibres were located around blood vessels and salivary acini. In the submandibular gland the number of immunoreactive nerve fibres around the acini was lower in comparison with that in the parotid and sublingual glands. Some immunoreactive nerve fibres were also found around or along intra- and interlobular ducts in all major salivary glands. A large number of the neuropeptide-containing neuronal cell bodies and nerve fibres were detected in the sympathetic superior cervical ganglion. Sympathetic postganglionic nerve trunks of this ganglion contained numerous immunoreactive nerve fibres as well. A subpopulation of the neuronal cell bodies in the submandibular ganglion were immunoreactive to neuropeptide Y. Both uni- and bilateral superior cervical ganglionectomies caused a significant decrease in the number of immunoreactive nerve fibres around the blood vessels in all the major salivary glands. However, these denervations did not affect the density of nerve fibres around the acini and ducts. On the contrary, unilateral parasympathetic denervation by sectioning the auriculotemporal nerve reduced the fibres around the secretory acini in the parotid gland remarkably, while only a minor reduction in the density of immunoreactive fibres associated with the blood vessels of the gland was detected. Unilateral electrocoagulation of the trigeminal nerve branches caused no detectable change in the density of immunoreactive nerve fibres in any of the major salivary glands.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Parasympathetic Npy-fibresmentioning

confidence: 99%

The sympathetic and parasympathetic nature of neuropeptide Y-immunoreactive nerve fibres in the major salivary glands of the rat

et al. 1994

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“…The tachykinins are a family of peptides that share a common carboxyl-terminal sequences and are extensively distributed in central nervous system and their periphery nerves, includes salivary glands (1,2). The tachykinins exert their physiological activities through activation of three subtypes of NK receptors, NK1, NK2 and NK3 receptors (3).…”

Section: Introductionmentioning

confidence: 99%

Characterization of neurokinin A-evoked salivary secretion in the perfused rat submandibular gland

Narita

Fukano

et al. 2009

J. Med. Invest.

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Neurokinin A (NKA) evokes salivary secretion. Despite such reports, the direct effect of NKA on salivary secretion in submandibular gland has not been clarified. Here we studied characterization of salivary fluid secretion induced by NKA in the perfused submandibular grand (SMG) of the rat. NKA (3-100 nM) stimulated salivary fluid secretion in a dose-dependent manner. The profile of secretion induced by NKA consisted of two phases, transient and sustained phases. When the gland was perfused with Lucifer yellow (LY)-containing perfusate buffer and stimulated by NKA, concentration of LY in saliva was increased. In the absence of Ca(2+) in the perfusate, NKA induced only a transient salivary fluid and a transient LY secretion. When the gland was treated with BAPTA, NKA failed to induce both salivary fluid secretion and LY secretion. These results suggest that NKA induces salivary secretion via both transcellular and paracellular pathways, which depends on intracellular Ca(2+) mobilization.

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Substance P and neurokinin A immunoreactive nerve fibres in the developing salivary glands of the rat

1992

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The time of appearance and distribution of substance P (SP) and neurokinin A (NKA) immunoreactive nerve fibres in developing salivary glands of the rat were studied by the use of indirect immunohistochemical methods. The glands were examined at daily intervals from the 15th day in utero (i.u.) until birth, and subsequently on the 2nd, 5th, 7th, 12th, 16th and 30th postnatal day. The findings were compared to samples from adult. The first SP- and NKA-immunoreactive (IR) nerve fibres appeared on the 19th day i.u. in the parotid and submandibular glands and were abundantly distributed around developing ductal branches. In the mesenchyme around the developing ductal branches of the parotid gland the fibres appeared on the 20th day i.u. In the submandibular gland NKA-IR fibres appeared in the mesenchyme surrounding the developing ductal branches on the 19th day i.u. and SP-IR fibres on the 21st day i.u. Around blood vessels of both glands, SP- and NKA-IR fibres made their appearance only much later, on the second postnatal day. The number of SP- and NKA-IR nerve fibres in the developing salivary glands was already high on the 19th day i.u. when they were first detected. From this point up to the 16th postnatal day the glands were richly innervated by the fibres, but later the numbers slowly decreased to adult levels. The abundance of SP- and NKA-IR nerve fibres especially around the ductal branches and secretory structures in the developing salivary glands suggests a role in the functional maturation of salivary glands.

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Neurokinin A in the parotid and submandibular glands of the rat: immunohistochemical localization and effect on protein and peroxidase secretion

Cited by 14 publications

References 33 publications

The sympathetic and parasympathetic nature of neuropeptide Y-immunoreactive nerve fibres in the major salivary glands of the rat

The sympathetic and parasympathetic nature of neuropeptide Y-immunoreactive nerve fibres in the major salivary glands of the rat

Characterization of neurokinin A-evoked salivary secretion in the perfused rat submandibular gland

Substance P and neurokinin A immunoreactive nerve fibres in the developing salivary glands of the rat

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