NEUROLEPTANAESTHESIA FOR MAJOR SURGERY: Experience with 500 Cases

Morgan, M.; Lumley, Jean; Gillies, Iain

doi:10.1093/bja/46.4.288

Cited by 24 publications

(5 citation statements)

References 26 publications

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“…Neuroleptanaesthesia has established itself as a very useful technique. Its major advantages include an uncomplicated induction, cardiovascular stability during maintenance of anaesthesia and a recovery phase characterized by a rapid return to consciousness and absence of restlessness and vomiting (Morgan, Lumley and Gillies, 1974). However, the "ideal" anaesthetic agent should either have a short duration of action or have an effective antagonist.…”

mentioning

confidence: 99%

“…Neither criterion is truly satisfied by the drugs used during neuroleptanaesthesia, such as fentanyl and droperidol. Indeed, Morgan, Lumley and Gillies (1974) report that 18% of their patients did not establish adequate spontaneous ventilation at the end of anaesthesia. In addition, planned major operations may be terminated unexpectedly and so the search for an effective antagonist is of practical importance.…”

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confidence: 99%

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A Comparison in Mice of Naloxone and Nalorphine as Antagonists to Neuroleptanalgesic Drugs

Smith

1976

British Journal of Anaesthesia

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The effectiveness of naloxone and nalorphine in antagonizing the effects of fentanyl and droperidol on the hot plate reaction time and the respiratory rate of the mouse has been compared. Naloxone was superior to nalorphine, being a more effective antagonist, and was also free from significant agonist effects. However, neither antagonist was completely effective against the respiratory rate depression produced by combinations of fentanyl and droperidol. It is suggested that the duration of the antagonist effects of naloxone are shorter against respiratory depression than against analgesia.

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confidence: 99%

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confidence: 99%

A Comparison in Mice of Naloxone and Nalorphine as Antagonists to Neuroleptanalgesic Drugs

Smith

1976

British Journal of Anaesthesia

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“…[3536] Neuroleptanaesthesia (combination of droperidol and fentanyl) appears to offer some advantage as it preserves a good cardiovascular stability during pheochromocytoma resection. [37] Droperidol has got antiarrhythmic effects and acts as antiemetic by blocking α-2 receptors and inhibiting catecholamine re-uptake.…”

Section: Peri-op Anesthetic Managementmentioning

confidence: 99%

Implications and considerations during pheochromocytoma resection: A challenge to the anesthesiologist

Bajwa

2011

Indian J Endocr Metab

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Pheochromocytoma is a rare catecholamine secreting tumor arising commonly from adrenal medulla. It has got multidimensional challenging aspects in spite of our improved understanding of its physiological and clinical behavior during surgical resection. This neuroendocrine tumor is associated with a most unpredictable and fluctuating clinical course during anesthesia and surgical intervention. The clinical difficulties and challenges increase manifold in patients with undiagnosed or accidental diagnosis of pheochromocytoma who present to the hospital for the treatment of some other disease or emergency. The most common manifestations of this clinical spectrum include hypertension, headache, palpitations, episodic sweating, and feeling of doom. The definite and only treatment for this rare tumor is surgical resection which itself is very challenging for an anesthesiologist. This article reviews the pre-operative evaluation, pharmacological preparation, intraoperative and post-operative management of patients with pheochromocytoma especially from anesthesiologist's perspectives.

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“…The amount of analgesic used may be compared with that in two other similar trials (table VI). Morgan, Lumley and Gillies (1974) found an average requirement of fentanyl of 0.102 mg/h (approximately 0.24 (xg/kg/min), and Foldes, Shiflman and Kronfeld (1970), in a double-blind trial, found the requirement of fentanyl to be 0.33 + 0.002 [xg/kg/min, and of pethidine to be 28.2 + 1.5 [xg/kg/min (in the patients who received a non-depolarizing muscle relaxant). These figures are at the lower limit of the dose range found in the present trial, but in both of the other studies droperidol was used in addition, and the concentrations of nitrous oxide were greater.…”

Section: Total Dose Of Analgesicmentioning

confidence: 99%

Supplementation of General Anaesthesia With Narcotic Analgesics

Holmes

1976

British Journal of Anaesthesia

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Four analgesic drugs--fentanyl, phenoperidine, morphine and pethidine--were compared in a double-blind trial involving 113 patients paralysed and ventilated with nitrous oxide and oxygen. The differences between the drugs were relatively small. There were only slight differences in "duration of action", a term which is questioned in this context. Pethidine appeared to have a slightly longer duration of action than the other drugs. The problems inherent in studying analgesics in this manner are discussed.

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NEUROLEPTANAESTHESIA FOR MAJOR SURGERY: Experience with 500 Cases

Cited by 24 publications

References 26 publications

A Comparison in Mice of Naloxone and Nalorphine as Antagonists to Neuroleptanalgesic Drugs

A Comparison in Mice of Naloxone and Nalorphine as Antagonists to Neuroleptanalgesic Drugs

Implications and considerations during pheochromocytoma resection: A challenge to the anesthesiologist

Supplementation of General Anaesthesia With Narcotic Analgesics

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