Neuroleptic binding to sigma receptors: Possible involvement in neuroleptic-induced acute dystonia

Jeanjean, Anne; Laterre, Emile-Christian; Maloteaux, Jean‐Marie

doi:10.1016/s0006-3223(96)00264-8

Cited by 32 publications

(14 citation statements)

References 52 publications

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“…Haloperidol administration can also result in dystonia that is blocked by BMY-14802, suggesting that haloperidol may act as an agonist at sigma receptors (Okumura et al, 1996). Based on these findings as well as other reports, it has been postulated that sigma receptors may, at least in part, be involved in drug-induced dystonia associated with neuroleptic treatment (Jeanjean et al, 1997).…”

supporting

confidence: 51%

Sigma binding sites identified by [3H] DTG are elevated in aged Fischer-344 � Brown Norway (F1) rats

Wallace

Mactutus

Booze

2000

Synapse

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supporting

confidence: 51%

Sigma binding sites identified by [3H] DTG are elevated in aged Fischer-344 � Brown Norway (F1) rats

Wallace

Mactutus

Booze

2000

Synapse

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“…This distribution is seen phenotypically with one group expressing a higher activity (COMTVal/Val), which translates into a fast metabolism of levodopa, a second group with intermediate activity (COMTVal/Met) and one with low activity (COMTMet/Met) [88,89,90]. Ethnic variations in COMT activity have been observed, such as a higher prevalence of the high activity variant in African people, and this issue therefore needs to be further investigated in future studies within Asian cohorts [91,92,93].…”

Section: Discussionmentioning

confidence: 99%

Non-Motor Symptoms Assessed by Non-Motor Symptoms Questionnaire and Non-Motor Symptoms Scale in Parkinson's Disease in Selected Asian Populations

Sauerbier

Jitkritsadakul²,

Titova³

et al. 2017

Neuroepidemiology

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Background: Ethnic variations have been described in medical conditions, such as hypertension, diabetes, and multiple sclerosis. Whether ethnicity plays a role in Parkinson's disease (PD), particularly with regard to non-motor symptoms (NMS), remains unclear. Existing literature is diverse, controversial, and inadequately documented. This review aims to analyse and report the currently available literature on NMS, specifically in Asian PD patients. Summary: We conducted a literature review using PubMed, searching for articles and currently available publications that reference and assess NMS in PD patients living in Asia using the validated NMS Questionnaire (NMS Quest) and NMS Scale (NMSS). In total, 24 articles were included: 12 using the NMS Quest and 12 using the NMSS. Symptoms of constipation, memory impairment, and nocturia were the most frequently self-reported symptoms (NMS Quest) in selected Asian populations, while symptoms within the domains sleep/fatigue, attention/memory, and mood/apathy were most prevalent when applying the health-professional completed NMSS. Key Messages: NMS are generally prevalent and highly burdensome within selected Asian PD populations living in countries included in this review. Our review suggests that NMS-driven phenotypic heterogeneity is present in Asian patients, and compared to Western PD populations there might be variations in assessed NMS.

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“…The analyses were performed using Comprehensive Meta-Analysis Version 2 software (Biostat, Englewood, New Jersey, USA). A codominant genetic model was chosen because Val158 and Met158 alleles determine human COMT activity codominantly [75][76][77]. We used a random effects model that accounts for the heterogeneity found between the studies.…”

Section: Methodsmentioning

confidence: 99%

Catechol-O-methyltransferase gene polymorphism and chronic human pain

Tammimäki

Männistö

2012

Pharmacogenetics and Genomics

148

109

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In human studies, low COMT (catechol-O-methyltransferase) activity has been associated with increased sensitivity to acute clinical preoperative or postoperative pain. We explored the association between the COMT genotype and three chronic pain conditions: migrainous headache, fibromyalgia, or chronic widespread pain and chronic musculoskeletal pain. Furthermore, we evaluated whether COMT genotype affects the efficacy of opioids in chronic pain. After a systematic literature review, we carried out meta-analyses on the three chronic pain conditions. The efficacy of opioids was evaluated using a systematic review only. The meta-analyses showed that fibromyalgia or chronic widespread pain is the only type of chronic pain that could be associated with the COMT single nucleotide polymorphism rs4680 (Val158Met). Met158, which results in the low-activity variant of COMT, is the risk allele. In chronic clinical pain, the effect of the COMT polymorphism depends on the pain condition. Low COMT activity is not associated with migrainous headache or chronic musculoskeletal pain conditions, but it may increase the risk for fibromyalgia or chronic widespread pain. Low COMT activity increases opioid receptors and enhances opioid analgesia and adverse effects in some cancer pains. Findings from animal studies that have utilized COMT inhibitors elucidate the mechanism behind these findings. In rodent pain models, COMT inhibitors are pronociceptive, except for neuropathic pain models, where nitecapone was found to be antiallodynic. The complex interplay between enhanced adrenergic and dopaminergic activity in different parts of the nociceptive system probably explains the complicated actions of low COMT activity.

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Neuroleptic binding to sigma receptors: Possible involvement in neuroleptic-induced acute dystonia

Cited by 32 publications

References 52 publications

Sigma binding sites identified by [3H] DTG are elevated in aged Fischer-344 � Brown Norway (F1) rats

Sigma binding sites identified by [3H] DTG are elevated in aged Fischer-344 � Brown Norway (F1) rats

Non-Motor Symptoms Assessed by Non-Motor Symptoms Questionnaire and Non-Motor Symptoms Scale in Parkinson's Disease in Selected Asian Populations

Catechol-O-methyltransferase gene polymorphism and chronic human pain

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