Neuroleptic sensitivity and enzyme deficiency in two schizophrenic brothers: A case report

Pharmacogenetics in the postgenomic era.

“…With respect to antipsychotic response, typical antipsychotic sensitivity has been reported as cosegregating with CYP2D6 phenotype (Aitchison et al, 1995), andVojvoda, Grimmel, Sernyak, andMazure (1996) reported a set of monozygotic twins, each with a D S M -N diagnosis of schizophrenia (4th edition of the Diagnostic and Statistical Manual of Mental Disorders; American Psychiatric Association, 1994), who were concordant for treatment refractoriness to various typical antipsychotic agents, but who had a positive response to clozapine. Furthermore, a heritable component to antipsychotic response has been demonstrated by studies with mouse strains that differ in antipsychotic responsiveness (Dains, Hitzemann, & Hitzemann, 1996) and indicated by a human family study (Sautter, McDermott, & Gamer, 1993) and studies indicating differential response to antipsychotics in different ethnicity groups (Aitchison, Jordan, & Sharma, 2000;Frackiewicz, Sramek, Herrera, Kurtz, & Cutler, 1997).…”