Neurologic Complications in Children with Systemic Cancer

Antunes, Nuno Lobo

doi:10.1007/978-1-59259-317-0_31

Cited by 2 publications

(2 citation statements)

References 130 publications

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“…Kidney cancer, multiple myeloma, and nonHodgkin's lymphoma are also relatively frequent, each being responsible for about 5% to 10% of cases [4,6,7]. In children, SCC is commonly seen in sarcomas, neuroblastoma, germ cell tumors, and Hodgkin's lymphoma [8]. Although most cases of SCC occur in patients with a previous diagnosis of cancer, the presence of a primary cancer is not known at the time of presentation in up to 10% to 20% of patients [1,4].…”

Section: Introductionmentioning

confidence: 98%

Spinal cord compression in cancer patients: Review of diagnosis and treatment

Penas‐Prado

Loghin²

2008

Curr Oncol Rep

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Spinal cord compression (SCC) is a well-known complication in cancer patients, with an enormous potential impact on quality of life. In most cases, treatment is palliative, but a prompt diagnosis and immediate treatment is essential to preserving neurological function. Whereas steroids and radiation have been the mainstay of therapy for many years, the role and timing of surgery has remained controversial. However, class I evidence now exists to support the benefit of pre-irradiation surgical decompression in a carefully selected subpopulation of patients with SCC. A multidisciplinary approach is required to maximize the therapeutic and functional outcome of these patients.

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Section: Introductionmentioning

confidence: 98%

Spinal cord compression in cancer patients: Review of diagnosis and treatment

Penas‐Prado

Loghin²

2008

Curr Oncol Rep

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“…A total of 25%-50% of patients can be expected to exhibit abnormal neurological signs due to various etiologies. Gross and fine motor dysfunction, as well as neuropsychological deficits, are encountered in a significant number of children years after the termination of treatment [1,2].…”

Section: Introductionmentioning

confidence: 99%

On the origin of EEG‐slowing and encephalopathy during induction treatment of acute lymphoblastic leukemia

Korinthenberg

Scheuring

Boos

et al. 2002

Med. Pediatr. Oncol.

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The greater part of EEG changes observed in the early treatment of ALL is due to disease-related factors. Treatment with prednisone, vincristine, and to a much lesser degree asparaginase aggravates the pre-existing encephalopathy. Depletion of CSF from asparagine does not give rise to additional changes. In the second month, the EEG normalizes despite ongoing treatment with different cytotoxic drugs.

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Neurologic Complications in Children with Systemic Cancer

Cited by 2 publications

References 130 publications

Spinal cord compression in cancer patients: Review of diagnosis and treatment

Spinal cord compression in cancer patients: Review of diagnosis and treatment

On the origin of EEG‐slowing and encephalopathy during induction treatment of acute lymphoblastic leukemia

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