Neurologic Complications of Cardiac Surgery and Interventional Cardiac Procedures

Biller, José; Hocker, Sara E.; Morales-Vidal, Sarkis

doi:10.3810/hp.2010.11.344

Cited by 2 publications

(1 citation statement)

References 65 publications

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“…The cellular pathways of EPC mobilization and trafficking are becoming clear. During tissue ischemia, the increased expression and stabilization of the transcription factor hypoxia inducible factor‐1α promotes the local production of stromal cell‐derived factor‐1α (SDF‐1α) and vascular endothelial growth factor‐A (VEGF‐A) by hypoxic endothelial cells (Biller et al ., ; Zhao et al ., ), and the SDF‐1/CXCR4 axis has been confirmed to play a key role in EPC mobilization in response to hypoxia or injury (Solomon et al ., ; Munoz et al ., ). The VEGF also induces tumor cells to express matrix metalloproteinase‐9 and triggers the release of the stem cell‐active soluble kit ligand, which in turn induces the translocation of quiescent VEGFR2 + c‐kit + EPC into the circulation for recruitment to sites of ischemia, inflammation or tumor growth (Chowdhary et al ., ).…”

Section: Discussionmentioning

confidence: 99%

The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization

Lin

Huang

et al. 2014

Molecular Oral Microbiology

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Porphyromonas gingivalis is a bacterial species that causes destruction of periodontal tissues. Additionally, previous evidence indicates that GroEL from P. gingivalis may possess biological activities involved in systemic inflammation, especially inflammation involved in the progression of periodontal diseases. The literature has established a relationship between periodontal disease and cancer. However, it is unclear whether P. gingivalis GroEL enhances tumor growth. Here, we investigated the effects of P. gingivalis GroEL on neovasculogenesis in C26 carcinoma cell-carrying BALB/c mice and chick eggs in vivo as well as its effect on human endothelial progenitor cells (EPC) in vitro. We found that GroEL treatment accelerated tumor growth (tumor volume and weight) and increased the mortality rate in C26 cell-carrying BALB/c mice. GroEL promoted neovasculogenesis in chicken embryonic allantois and increased the circulating EPC level in BALB/c mice. Furthermore, GroEL effectively stimulated EPC migration and tube formation and increased E-selectin expression, which is mediated by eNOS production and p38 mitogen-activated protein kinase activation. Additionally, GroEL may enhance resistance against paclitaxel-induced cell cytotoxicity and senescence in EPC. In conclusion, P. gingivalis GroEL may act as a potent virulence factor, contributing to the neovasculogenesis of tumor cells and resulting in accelerated tumor growth.

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Section: Discussionmentioning

confidence: 99%

The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization

Lin

Huang

et al. 2014

Molecular Oral Microbiology

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Evaluation of Complications Associated with Cardiac Catheterization: A Single-center Experience

Abalı¹,

Nişli²,

Dindar³

et al. 2022

Trends in Pediatrics

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Objective: The aim of this study is to evaluate complications of cardiac catheterization (CC) procedures in a pediatric cardiology center. Methods: The clinical records of 781 cardiac catheterizations were reviewed to identify procedure-associated complications. Catheterizations were grouped as diagnostic or interventional procedures. A complication was classified as a major or a minor. Results: Patient ages ranged from 1 day to 28.8 years (median 3.3 years). Interventional catheterizations represented 58.5% of total procedures. Patent ductus arteriosus (PDA), atrial septal defect (ASD), and aortic coarctation were the most common diagnoses in our cohort. PDA occlusion, ASD closure, pulmonary valvuloplasty, angioplasty/stenting for aortic coarctation, and aortic valve dilation were the most commonly performed interventional catheterizations. Complications were detected in 17.5% of all procedures. Major complications were 2.3% for all procedures. Decreased/absent pulses were the most common complication in all categories (8.1%). The mortality rate of cardiac catheterization procedures was 0.5%. Relative to diagnostic procedures, interventional catheterizations were associated with a greater risk of complications. Conclusion: Our study’s success and complication rates were similar to other studies. Complications of CC depend on the severity of the underlying congenital heart disease and the type of procedure.

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Neurologic Complications of Cardiac Surgery and Interventional Cardiac Procedures

Cited by 2 publications

References 65 publications

The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization

The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization

Evaluation of Complications Associated with Cardiac Catheterization: A Single-center Experience

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