Neurologic Disease after Yellow Fever Vaccination, São Paulo, Brazil, 2017–2018

Ribeiro, Ana Freitas; Guedes, Bruno Fukelmann; Sulleiman, Jamal M. A. H.; Oliveira, Fabiana Sodré de; Souza, Izabel Oliva Marcilio de; Nogueira, Juliana Silva; Marcusso, Rosa Maria Nascimento; Fernandes, Eder Gatti; Olival, Guilherme Sciascia do; Figueiredo, Pedro Henrique Fonseca Moreira de; Veiga, Ana Paula Rocha; Dahy, Flávia Esper; Ximenes, Natalia Nasser; Pinto, Lécio Figueira; Vidal, José Ernesto; Oliveira, Augusto César Penalva de

doi:10.3201/eid2706.204170

Cited by 15 publications

(5 citation statements)

References 32 publications

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“…Similarly, our patient's EEG findings are notable when compared to other published cases which have either been unremarkable (n = 2), demonstrate disorganized background (n = 8), or revealed generalized low-amplitude slowing (4,9). Recovery in most cases is complete in relatively quick fashion without significant sequelae (4) although deaths have been described in patients with YEL-AND (3), definitive attribution to the vaccine is difficult to establish (9). Our patient had a relatively prolonged course and while her imaging findings, seizures, and EEG did improve significantly relatively early in her hospital course, sequelae of intraparenchymal damage, specifically to the basal ganglia, complicated recovery with the development of Parkinsonism requiring dopaminergic therapy.…”

Section: Discussionsupporting

confidence: 70%

“…Additionally, reports of MRI imaging findings in YEL-AND have been limited to date. Similarly, our patient's EEG findings are notable when compared to other published cases which have either been unremarkable (n = 2), demonstrate disorganized background (n = 8), or revealed generalized low-amplitude slowing (4,9). Recovery in most cases is complete in relatively quick fashion without significant sequelae (4) although deaths have been described in patients with YEL-AND (3), definitive attribution to the vaccine is difficult to establish (9).…”

Section: Discussionsupporting

confidence: 46%

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Case Report: Yellow Fever Vaccine-Associated Neurotropic Disease and Associated MRI, EEG, and CSF Findings

et al. 2022

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Yellow fever vaccine-associated neurotropic disease (YEL-AND) is a rare and serious complication following vaccination with the 17D live attenuated yellow fever vaccine. Cases of YEL-AND have presented as acute inflammatory demyelinating polyneuropathy, acute disseminated encephalomyelitis, and meningoencephalitis. To date, intracranial imaging of the progression and resolution of this disease has been minimally depicted in the literature. We present the case of a 67-year-old woman who developed YEL-AND following vaccination. Her diagnosis was complicated by imaging findings consistent with variant Creutzfeldt Jakob Disease. Her clinical history and the progression of her intracranial imaging is discussed in this case report.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionsupporting

confidence: 46%

Case Report: Yellow Fever Vaccine-Associated Neurotropic Disease and Associated MRI, EEG, and CSF Findings

et al. 2022

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“…This is consistent with the rapidly increasing proportion of patients with encephalitis thought to be of immune origin despite undetectable neuronal surface autoantibodies in serum and CSF ( 15 , 33 – 35 ), and absent structural abnormalities on neuroimaging studies ( 35 ). The data linking vaccines to autoimmune encephalitis are very scarce and largely limited to sporadic cases of yellow fever vaccine ( 36 , 37 ). Therefore, it remains unclear whether this presentation is a coincidental event that occurred following, or an adverse event linked to, vaccination.…”

Section: Discussionmentioning

confidence: 99%

A Single-Health System Case Series of New-Onset CNS Inflammatory Disorders Temporally Associated With mRNA-Based SARS-CoV-2 Vaccines

et al. 2022

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BackgroundSince 2020, over 250 million doses of mRNA-based SARS-CoV-2 vaccines have been administered in the United States and hundreds of millions worldwide between the Pfizer-BioNTech and Moderna SARS-CoV-2 vaccines. To date, there have been rare reports associating mRNA-based SARS-CoV-2 vaccines with episodes of inflammatory and autoimmune CNS disorders. We report a case series of five patients with new-onset neurological disorders of inflammatory or immunological origin temporally associated with these vaccines.MethodsA case-series of five patients within a single 23-hospital health system who developed new-onset CNS inflammatory disease within 2 weeks of receiving a dose of an mRNA-based SARS-CoV-2 vaccine.ResultsFive cases of post-vaccination CNS disorders of immune origin (fatal ADEM; n = 1, new-onset NMOSD; n = 2, new-clinical onset MS-like syndrome but with preexisting clinically silent mild demyelination; n = 1, meningoencephalitis; n = 1) observed within 2 weeks of inoculation with either the first or second dose of mRNA-based SARS-CoV-2 vaccines (Moderna = 3, Pfizer = 2).DiscussionTo our knowledge, these are among the emerging cases of CNS adverse events of immunological or inflammatory origin. These findings should be interpreted with great caution as they neither prove a mechanistic link nor imply a potential long-term increased risk in post-vaccination CNS autoimmunity. Larger prospective studies assessing the potential association between mRNA-based vaccination and the development of neurological adverse events of suspected immune origin, particularly among those with underlying CNS or systemic autoimmune disorders, are needed. The use of mRNA-based SARS-CoV-2 vaccines should continue to be strongly encouraged given their high efficacy in overcoming this pandemic.

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“…The neurotropic West Nile virus may cause severe encephalitis in humans and horses. This drug endangers newborns, elderly individuals, and those with weaker immune systems (63). Microcephaly, cortical thinning, and vision impairment have been linked to Zika virus infection during pregnancy.…”

Section: Global Warming and Pdmentioning

confidence: 99%

Connecting the Dots: AfrAbia's Environmental Challenges and Parkinson's Disease

Mohamed

2024

Preprint

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Background: Parkinson's disease (PD) is a global disease. However, there is a lack of research specifically focused on the AfrAbia population. Climate change, driven mainly by global warming, is linked to detrimental health impacts, including an increased frequency and intensity of heat waves. Neurological diseases, including neurodegenerative syndromes like Alzheimer's disease, Parkinson's disease, and motor neuron illnesses, have been increasingly seen and recorded in scientific literature. Although there is much literature demonstrating the growth in neurodegenerative disorders, the relationship between environmental variables such as global warming, air pollution, heavy metals, and pesticides and the higher occurrence of these illnesses is still unknown. Objective: The current article primarily aims to examine the relationship between climatic changes, air pollution, pesticides, heavy metals, and the occurrence of PD. Initially, we evaluate the influence of exposure to these variables on the cause or origin of Parkinson's disease. In addition, we will investigate how these variables disrupt processes such as excitotoxicity, oxidative stress, and neuroinflammation, all of which are strongly linked to Parkinson's disease (PD). Conclusions: This research presents a plausible rationale for the adverse effects of environmental influences on the brain, which are pivotal in the progression or onset of Parkinson's disease from an AfrAbian standpoint.

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Neurologic Disease after Yellow Fever Vaccination, São Paulo, Brazil, 2017–2018

Cited by 15 publications

References 32 publications

Case Report: Yellow Fever Vaccine-Associated Neurotropic Disease and Associated MRI, EEG, and CSF Findings

Case Report: Yellow Fever Vaccine-Associated Neurotropic Disease and Associated MRI, EEG, and CSF Findings

A Single-Health System Case Series of New-Onset CNS Inflammatory Disorders Temporally Associated With mRNA-Based SARS-CoV-2 Vaccines

Connecting the Dots: AfrAbia's Environmental Challenges and Parkinson's Disease

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