Neurologic disease associated with 17D-204 yellow fever vaccination: A report of 15 cases

McMahon, Ann; Eidex, Rachel B.; Marfin, Anthony A.; Russell, Mary Jo; Sejvar, James J.; Markoff, Lewis; Hayes, Edward B.; Chen, Robert T.; Ball, Robert; Braun, M. Miles; Cetron, Martín S.

doi:10.1016/j.vaccine.2006.11.027

Cited by 125 publications

(76 citation statements)

References 19 publications

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“…20 It became clear that YEL-AND cases occur several days or weeks after vaccination. Rates during a campaign in 2009 in RS (Rio Grande do Sul State) with enhanced passive surveillance were much higher than with the routine passive surveillance in the rest of Brazil.…”

Section: Vaccine-associated Neurotropicmentioning

confidence: 99%

Serious adverse events associated with yellow fever vaccine

Martins

Leal²,

Homma³

2015

Human Vaccines & Immunotherapeutics

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Section: Vaccine-associated Neurotropicmentioning

confidence: 99%

Serious adverse events associated with yellow fever vaccine

Martins

Leal²,

Homma³

2015

Human Vaccines & Immunotherapeutics

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“…Outros efeitos adversos relatados podem ser locais (dor localizada, enduração, eritema, calor), de natureza neurológica (mielite, alteração de status mental, déficits focais, paresias, vertigem, cefaléia) 15 ou multi-sistêmicos (mialgia, artralgia, rabidomiólise, aumento de transaminases, náuseas, vômitos, diarréia). Também, podem ser devido a reações de hipersensibilidade como exantema, urticária, febre, anafilaxia, asma ou angioedema 17 .…”

Section: Mota Lmh Colsunclassified

Vacinação contra febre amarela em pacientes com diagnósticos de doenças reumáticas, em uso de imunossupressores

Mota

Oliveira

Lima

et al. 2009

Rev. Soc. Bras. Med. Trop.

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A febre amarela é uma doença viral, infecciosa não-contagiosa, endêmica em regiões da África e da América do Sul. É transmitida pela picada de insetos hematófagos da família Culicidae, em especial dos gêneros Aedes e Haemagogus 22 . Vacinação contra febre amarela em pacientes com diagnósticos de doenças reumáticas, em uso de imunossupressores ABSTRACTYellow fever is endemic in some countries. The anti-yellow fever vaccine is the only effective means of protection but is contraindicated for immunocompromised patients. The aim of this paper was to report on a case series of rheumatological patients who were using immunosuppressors and were vaccinated against this disease. This was a retrospective study by means of a questionnaire applied to these patients, who were vaccinated 60 days before the investigation. Seventy patients of mean age 46 years were evaluated. Most of them were female (90%). There were cases of rheumatoid arthritis (54), systemic lupus erythematosus (11), spondyloarthropathy (5) and systemic sclerosis (2). The therapeutic schemes included methotrexate (42), corticosteroids (22), sulfasalazine (26), leflunomide (18), cyclophosphamide (3) and immunobiological agents (9). Sixteen patients (22.5%) reported some minor adverse effect. Among the eight patients using immunobiological agents, only one presented a mild adverse effect. Among these patients using immunosuppressors, adverse reactions were no more frequent than among immunocompetent individuals. This is the first study on this topic. A suscetibilidade é geral e irrestrita, não havendo distinção de raça, idade ou gênero. As manifestações clínicas variam desde um quadro febril leve à infecção grave, acarretando falência renal e hepática, dano cardíaco, hemorragia e choque 23 . Estima-se que apenas 10% sejam formas graves, associadas à elevada letalidade, variando de 20-50% dos casos 1 22 . Não há tratamento específico para a doença. Key

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“…7 YF-AND may include post-vaccinal encephalitis, autoimmune disease with central or peripheral nervous system disease, or Guillain-Barre syndrome. 8 The mechanism of YF-AND is unclear, but it has been proposed that it may be related to levels of postvaccination viremia and/or host response factors. YF-AVD resembles wild-type disease, with vaccine virus dissemination and replication in multiple organs.…”

Section: Introductionmentioning

confidence: 99%

A Randomized, Double-Blind, Controlled Trial of the 17D Yellow Fever Virus Vaccine Given in Combination with Immune Globulin or Placebo: Comparative Viremia and Immunogenicity

Edupuganti

Eidex²,

Keyserling

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. We evaluated whether coadministration of the yellow fever (YF) virus vaccine with human immunoglobulin (Ig) that contained YF virus-neutralizing antibodies would reduce post-vaccination viremia without compromising immunogenicity and thus, potentially mitigate YF vaccine-associated adverse events. We randomized 80 participants to receive either YF vaccine and Ig or YF vaccine and saline placebo. Participants were followed for 91 days for safety and assessments of viremia and immunogenicity. There were no differences found between the two groups in the proportion of vaccinated participants who developed viremia, seroconversion, cluster of differentiation (CD)-8 + and CD4 + T-cell responses, and cytokine responses. These results argue against one putative explanation for the increased reporting of YF vaccine side effects in recent years (i.e., a change in travel clinic practice after 1996 when hepatitis A prophylaxis with vaccine replaced routine use of pre-travel Ig, thus potentially removing an incidental YF vaccineattenuating effect of anti-YF virus antibodies present in Ig) (ClinicalTrials.gov identifier: NCT00254826).

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Neurologic disease associated with 17D-204 yellow fever vaccination: A report of 15 cases

Cited by 125 publications

References 19 publications

Serious adverse events associated with yellow fever vaccine

Serious adverse events associated with yellow fever vaccine

Vacinação contra febre amarela em pacientes com diagnósticos de doenças reumáticas, em uso de imunossupressores

A Randomized, Double-Blind, Controlled Trial of the 17D Yellow Fever Virus Vaccine Given in Combination with Immune Globulin or Placebo: Comparative Viremia and Immunogenicity

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