Neurologic Diseases: Parkinson’s Disease

Kenanidis, Eustathios; Leonidou, Andreas; Potoupnis, Michael; Tsiridis, Eleftherios; Kourtis, Aristotelis; Baker, Richard P.

doi:10.1007/978-3-319-64177-5_11

Cited by 1 publication

(3 citation statements)

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“…1 The clinical manifestations can often be insidious and involve tremor, bradykinesia, rigidity contractures, dystonia and flexed posture. 1 , 2 The burden of the disease has risen exponentially over the past decade and is estimated in 6.1 million individuals globally, 3 with 1 million people suffering from the disease in the US alone. 4 …”

Section: Introductionmentioning

confidence: 99%

“…Spasticity, tremors and contracture result in abnormal muscle tone around the hip, and altered forces exerted on the hip joint. 2 , 5 As a result, subluxation, degenerative diseases and secondary skeletal deformities are far more common. 5 Postural instability predisposes Parkinson’s individuals to sustain a fall, whereas reduced bone mineral density is the sequelae of vitamin D deficiency, physical impairment and immobilization induced hypercalcaemia.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have revealed a higher incidence of dislocation and aseptic loosening following hip replacement procedures, owing primarily to the excessive muscle tone. 2 , 10 – 12 In addition to the disease influence on early failure of the prosthesis, higher fracture risk and poorer bone quality has been suggested. Several studies have shown poor outcomes associated with hip fracture surgery in PD, namely high mortality, early failure and perioperative complications.…”

Section: Introductionmentioning

confidence: 99%

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Clinical outcomes in elective total hip arthroplasty in Parkinson’s disease: a systematic review of the literature

et al. 2020

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Parkinson’s disease (PD) poses a significant challenge for the arthroplasty surgeon, owing to excessive muscle tone, higher fracture risk and poor bone quality. Several studies have reported high mortality, early failure and perioperative complications associated with hip fracture surgery in PD; however, no higher-level evidence exists regarding elective hip arthroplasty. The aim of our study was to perform a systematic review to evaluate the evidence basis and clinical outcomes pertaining to patients with underlying Parkinson’s disease undergoing elective total hip arthroplasty (THA). We searched MEDLINE, EMBASE and The Cochrane Central Register of Controlled Trials to identify studies evaluating the safety and clinical outcomes of THA in patients suffering from Parkinson’s. Our review conforms to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Ten studies encompassing 49,730 patients were included in our systematic review. Qualitative synthesis demonstrated comparable results between PD patients and controls with respect to one-year mortality and surgical site infections. PD patients experienced more medical complications, had a longer hospital stay and worse long-term implant survival. Some studies also reported a higher rate of dislocation, periprosthetic fractures and aseptic loosening. Decisions about the optimal articulation, the utilization of cemented components, dual-mobility cups or constrained liners were not uniform among included studies. THA in patients with Parkinson’s disease can offer significant functional gains and pain relief. Surgical considerations pertain to the approach and ways to address instability, whereas emphasis should be placed on appropriate counselling and exploring whether potential improvement of life quality outweighs the risks. Cite this article: EFORT Open Rev 2020;5:856-865. DOI: 10.1302/2058-5241.5.200034

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Section: Introductionmentioning

confidence: 99%