Neurologic Manifestations of Glomus Tumors in the Head and Neck

Spector, Gershon J.; Druck, Norman S.; Gado, Mokhtar H.

doi:10.1001/archneur.1976.00500040054008

Cited by 69 publications

(19 citation statements)

References 7 publications

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“…15–19 However, for isolated sporadic glomus tumors, the subungual location is by far the most common (60%–80%). 20–22 Sex also plays a role in tumor location, with a subungual location being more common in women, but with no sex preference noted at other locations.…”

Section: Discussionmentioning

confidence: 99%

Glomus Tumors and Neurofibromatosis

Harrison

Sammer

2014

Plastic and Reconstructive Surgery Global Open

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Background:Glomus tumors are painful benign tumors arising from the neuromyoarterial elements of the glomus body, typically in a subungual location. Historically, glomus tumors have been considered isolated or sporadic, not typically associated with other disease processes. Over the last few years, however, multiple case reports, a molecular genetics study, and an epidemiologic study have confirmed an association between type I neurofibromatosis and glomus tumors. The purpose of this review is to summarize the existing information about the association between neurofibromatosis and glomus tumors and to determine whether glomus tumors that are associated with neurofibromatosis differ from isolated glomus tumors in terms of tumor number, location, and sex distribution.Methods:A PubMed, Ovid Medline, and Cochrane Database search was performed using the terms “glomus tumor,” “glomus tumour,” and “glomangioma” each combined with the search term “neurofibromatosis.” Fifteen English language articles were included. Information about the molecular genetics, patient sex, number of tumors per patient, and tumor location were recorded.Results:A total of 36 patients with glomus tumors and neurofibromatosis have been reported in the literature. Seventy-nine percent were female. Tumors were multifocal in 32% of patients, with an average of 1.4 glomus tumors per patient. Glomus tumors arose in a nonsubungual location in 38% of patients.Conclusions:A strong association between type I neurofibromatosis and glomus tumors has been identified. In neurofibromatosis patients with glomus tumors, the sex distribution, tumor location, and tumor burden appear similar to those in patients with isolated glomus tumors. Treating providers should be aware of this association to facilitate prompt diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Glomus Tumors and Neurofibromatosis

Harrison

Sammer

2014

Plastic and Reconstructive Surgery Global Open

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“…Familial VP may have a more aggressive growth pattern than a nonfamilial one [Bradshaw and Jansen, 2005]. Due to the high probability of a familial form of the disease [Spector et al, 1976;Zanoletti and Mazzoni, 2006], a detailed family history has to be obtained. If positive, genetic testing including VHL, RET, NF1, SDHD, SDHB and SDHC genes [Klein et al, 1993] is suggested for the patient and first-degree relatives.…”

Section: Discussionmentioning

confidence: 99%

Management of Vagal Paragangliomas Including Application of Internal Carotid Artery Stenting

et al. 2011

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Background: The primary treatment of vagal paraganglioma (VP) includes ‘wait and scan’, surgery and radiotherapy. Objectives: To present the clinical findings, surgical treatment including application of internal carotid artery (ICA) stenting to facilitate surgery, and complications, as well as to review the literature and to discuss the decision-making process in the management of VP cases based on our experience and the literature. Design: A retrospective case review of 22 cases with VP. Setting: Quaternary neurotologic and skull base referral center. Material and Methods: The retrospective chart review identified 22 patients presenting with VP. Our indication for surgery was VP in younger patients, irrespective of the existence of vocal cord paralysis. Preoperative endovascular management of the ICA included permanent balloon occlusion (PBO) and stenting. The transcervical approach and the infratemporal fossa approach type A (ITFA) were used. Results: Fifteen cases had multicentric paragangliomas, 5 cases bilateral tumors, 3 cases a genetic mutation, and 2 cases a positive family history. The most common symptoms were hoarseness, tinnitus and hearing loss. The surgical approaches commonly employed for excision were the transcervical approach (9 cases) and the ITFA (12 cases), whereas 1 case did not have surgery. Three cases had PBO and 7 had intracarotid stent insertion. Gross total removal was achieved in 19 cases, and 1 case had a recurrence. Eighteen cases had no dysphagia or were well compensated after surgery. There were no significant complications noted in our series. Conclusions: In younger patients with VP, surgery should be recommended. The proper preoperative endovascular intervention and surgical approach facilitates gross total tumor removal. In the management of bilateral or familial paragangliomas, careful and appropriate decision making is essential.

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“…Paraganglioma, also known as glomus tumor, is the most frequent neoplastic cause of pulsatile tinnitus [40, 41]. Most paragangliomas are sporadic, about 7–10% are familial and usually autosomal dominant in inheritance [42].…”

Section: Differential Diagnosis and Imaging Findingsmentioning

confidence: 99%

Pulsatile Tinnitus: Differential Diagnosis and Radiological Work-Up

Pegge¹,

Steens²,

Kunst³

et al. 2017

Curr Radiol Rep

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Purpose of ReviewIdentification of the underlying cause of pulsatile tinnitus is important for treatment decision making and for prognosis estimation. For this, an adequate diagnostic imaging strategy is crucial.Recent FindingsBoth CT and MRI can be useful, and in general, these modalities provide complementary diagnostic information. The scanning protocol can be optimized based on the estimated a priori chance for finding specific pathology, or the need to rule out more rare but clinical significant disease. In recent years, dynamic CTA, also referred to as 4D-CTA, has become available as a new technique that enables non-invasive evaluation of hemodynamics for the detection, classification, and follow-up of vascular malformations.SummaryThe value of different diagnostic imaging modalities in the work-up of pulsatile tinnitus is discussed in relation to the differential diagnosis. Furthermore, imaging findings of different diseases are presented, both for CT and MRI.Electronic supplementary materialThe online version of this article (doi:10.1007/s40134-017-0199-7) contains supplementary material, which is available to authorized users.

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Neurologic Manifestations of Glomus Tumors in the Head and Neck

Cited by 69 publications

References 7 publications

Glomus Tumors and Neurofibromatosis

Glomus Tumors and Neurofibromatosis

Management of Vagal Paragangliomas Including Application of Internal Carotid Artery Stenting

Pulsatile Tinnitus: Differential Diagnosis and Radiological Work-Up

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