Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

Abstract

IMPORTANCEThe outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, is serious and has the potential to become an epidemic worldwide. Several studies have described typical clinical manifestations including fever, cough, diarrhea, and fatigue. However, to our knowledge, it has not been reported that patients with COVID-19 had any neurologic manifestations.OBJECTIVE To study the neurologic manifestations of patients with COVID-19.

Olfactory Dysfunction in the COVID-19 Outbreak

“…Researchers detected SARS-CoV-2 nucleic acid in the cerebrospinal fluid of patients and also in their brain tissue on autopsy. The virus may enter the CNS through a hematogenous or retrograde neuronal route [44] (Figure 2). Previous studies have shown the ability of SARS-CoV to cause neuronal death in mice by invading the brain via the nose close to the olfactory epithelium [45].…”

“…A study from China reported that the ratio of hospitalized patients complaining of smell loss and taste loss was only 5.1% and 5.6%, respectively [44]. Three categories for neurological manifestations were described: CNS (dizziness, headache, impaired consciousness, acute cerebrovascular disease, ataxia, and seizure), peripheral nervous system (taste impairment, smell impairment, vision impairment, and nerve pain), and skeletal muscle injury.…”

Infección por SARS-CoV-2 asociada a diplopía y anticuerpos antirreceptor de acetilcolina

“…Diversas evidencias sugieren que dicho microorganismo puede penetrar en el sistema nervioso central produciendo complicaciones neurológicas (1). Algunos autores han reportado casos de encefalopatía (2), encefalopatía aguda hemorrágica necrotizante (3), meningoencefalitis (4), cefalea, mialgias, dolor neuropático, hiposmia, ageusia, ataxia, crisis epilépticas y manifestaciones cerebrovasculares (5). En nuestro conocimiento no se han descrito síntomas de compromiso del sistema nervioso periférico más allá de lo previamente referido.…”

Delirium and sleep disturbances in COVID–19: a possible role for melatonin in hospitalized patients?

“…Impaired consciousness ranging from somnolence to confusion, delirium, stupor and coma has been reported in almost 15% of hospitalized patients with Coronavirus Disease 2019 (COVIDe19) [1]. These disturbances might depend on a direct effect of the SARS-CoV-2, but also on well-known precipitating factors such as prolonged hospitalization, pain, constipation, urinary retention and a broad range of metabolic abnormalities that occur during the course of a severe infection.…”