Neurologıc Problems Accompanyıng Lung Cancer

Aydın, Şenay; Sohtaoğlu, Melis

doi:10.5152/tcb.2015.076

Cited by 2 publications

(1 citation statement)

References 48 publications

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“…Akciğer kanserinde, en sık beyin metastazı olmak üzere serebrovasküler hastalıklar, paraneoplastik nörolojik hastalıklar, radyoterapi ve kemoterapiye sekonder sinir sistemi hastalıkları gibi nörolojik sorunlar ortaya çıkabilir (1). İntrakranial metastazlardan hipofiz metastazı ise son derece nadirdir.…”

Section: Abstract: Hyperprolactinemia Lung Cancer Pituitary Metastunclassified

Pituitary Metastasis in Squamous Cell Lung Carcinoma

Akyıl¹,

Saygılı²,

Talay³

et al. 2019

Respir Case Rep

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ÖzetHipofiz metastazları asemptomatik olabilen, görüntülemelerde kolayca gözden kaçabilen ve çok nadir görülen metastazlardır. Bu olgu sunumunda, asemptomatik hipofiz metastazı saptanan akciğer skuamoz hücreli karsinomu tanısı konulan bir erkek hasta sunulmuştur. Yetmiş yaşında erkek hasta, genel durum bozukluğu nedeniyle çekilen toraks bilgisayarlı tomografide sağ alt lobda kitle tespit edilerek kliniğimize yönlendirildi. Bronkoskopide sağ ara bronşta izlenen lezyondan yapılan biyopsi skuamoz hücreli karsinom ile uyumluydu. Pozitron emisyon tomografi görüntülemede akciğer kitlesi, mediastinal lenfadenopatiler, karaciğer ve yaygın kemik metastazlarının yanında hipofiz sol kesiminde artmış metabolik aktivite izlendi. Hastanın hormon paneli hiperprolaktinemi ve hipogonadotropik hipogonadizm ile uyumluydu. Hipofiz manyetik rezonans görüntüleme infundibulum deviasyonu ve optik kiazma indentasyonu yapan 18x12 mm lezyon saptandı. Bu bulgularla hipofiz metastazı tanısı konulan hastaya radyoterapi planlandı fakat hasta tedavi alamayarak eksitus oldu. Akciğer kanserinde hipofiz bezi metastazı nadir de olsa görülebilir. Yalnız görüntüleme bulgularında saptanabilir veya takiplerde spesifik semptomlarla karşımıza çıkabilir.Anahtar Sözcükler: Akciğer kanseri, hiperprolaktinemi, hipofiz metastazı. AbstractMetastases to the pituitary gland are extremely rare, and can be asymptomatic and easily overlooked in imaging. In this case report, a male patient diagnosed with a lung squamous cell carcinoma with asymptomatic pituitary metastasis is presented. A 70year-old man was referred to our clinic with a right lower lobe mass identified in a thorax computed tomography. A bronchoscopic biopsy from the intermediate bronchus revealed a squamous cell carcinoma. Positron emission tomography imaging revealed increased metabolic activity in the lung mass; multiple mediastinal lymphadenopathies; liver and diffuse bone lesions along the left side of the pituitary gland. The patient's hormone panel was consistent with hyperprolactinemia and hypogonadotropic hypogonadism. Pituitary magnetic resonance imaging detected a deviation in the infundibulum and optic chiasm indentation with an 18 x 12 mm mass lesion. The patient was diagnosed with pituitary metastasis and radiotherapy was planned. The patient was unable to attend the followup and died within one month of diagnosis. Pituitary gland metastasis is extremely rare in lung cancer. It can be detected incidentally in imaging findings or from specific symptoms encountered during followup.

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Section: Abstract: Hyperprolactinemia Lung Cancer Pituitary Metastunclassified

Pituitary Metastasis in Squamous Cell Lung Carcinoma

Akyıl¹,

Saygılı²,

Talay³

et al. 2019

Respir Case Rep

View full text Add to dashboard Cite

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EFFECT OF BITTER MELON AGAINST CISPLATIN AND VALPROIC ACID-INDUCED GENOTOXICITY IN Drosophila melanogaster Meigen

ERSÖZ,

ALTUN ÇOLAK

2023

Trakya University Journal of Natural Sciences

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In human body, which is exposed to number of chemicals and physical agents in daily life, malfunctions may occur from time to time in detoxification mechanisms that will prevent the harmful effects of genotoxic agents, whose negative effects cannot be eliminated. In this study, the genoprotective effects of bitter melon (Momordica charantia L.) seed and fruit extracts against the genotoxic potential of the antineoplastic agent cisplatin and the antiepileptic drug valproic acid in 72±4 hours old transheterozygous larvae of the fruit fly Drosophila melanogaster Meigen were determined by the Somatic Mutation and Recombination Test (SMART). The results showed that the mutation frequencies approached the negative control values by inhibiting the formation of chemical agent-induced mutant clones in all doses in the experimental groups in which plant extracts were applied at doses of 1.25, 2.5 ve 5 mg/mL, while the mutation frequency increased only in the groups that applied cisplatin and valproic acid. These results show that co-administration of cisplatin and valproic acid reduces the genotoxic effect of M. charantia.

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Neurologıc Problems Accompanyıng Lung Cancer

Cited by 2 publications

References 48 publications

Pituitary Metastasis in Squamous Cell Lung Carcinoma

Pituitary Metastasis in Squamous Cell Lung Carcinoma

EFFECT OF BITTER MELON AGAINST CISPLATIN AND VALPROIC ACID-INDUCED GENOTOXICITY IN Drosophila melanogaster Meigen

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