Neurologic, Psychological, and Aggressive Disturbances with Sildenafil

Milman, Harry A.; Arnold, Suzanne B

doi:10.1345/1542-6270(2002)036<1129:npaadw>2.0.co;2

Cited by 3 publications

(4 citation statements)

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“…Several direct effects of sildenafil administration on the CNS were reported in both rodents and humans. These effects in human include dizziness, depression, insomnia, abnormal dreams, and nervousness (Moreira et al 2000;Milman and Arnold 2002). Also, recreational sildenafil use and its association with men's substance abuse behaviors are reported (Crosby and Diclemente 2004).…”

Section: Discussionmentioning

confidence: 99%

“…This hypothesis is powered by mentioned epidemiologic studies reporting that sildenafil is abused in a recreational fashion. Sildenafil crosses well the blood brain barrier (Marmor and Kessler 1999;Milman and Arnold 2002), exerts various biochemical and physiologic effects in the brain, and affects information processing. Pretreatment with sildenafil is shown to modify several behavioral signs centrally evoked by the D2/D3 dopamine agonists in experimentally naive male rats (Ferrari et al 2002).…”

Section: Introductionmentioning

confidence: 99%

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Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway

et al. 2006

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“…Although alcohol in small amounts improves erection and increases libido due to its vasodilatory effect and the suppression of anxiety, large amounts can cause central sedation, decreased libido, and transient erectile dysfunction (14). Other drugs linked with both sexual aggression and erectile dysfunction include anabolic steroids and sildenafil (15,16).…”

Section: Discussionmentioning

confidence: 99%

Assailants' Sexual Dysfunction During Rape: Prevalence and Relationship to Genital Trauma in Female Victims

Jones

Rossman

Wynn

et al. 2010

The Journal of Emergency Medicine

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“…Infrequent, adverse behavioral events with sildenafil include anxiety, agitation, nervousness, and attention disturbance. 6 Diagnosis and treatment of specific psychiatric and behavioral problems in people with mental retardation can be difficult. The Aberrant Behavior Checklist, Reiss Scales for Children's Dual Diagnosis, and Developmental Behavior Checklist have been used to identify maladaptive behaviors and psychiatric symptoms in children and adults with cognitive impairment.…”

Section: Yi Hui Liu MDmentioning

confidence: 99%

A 7-Year-Old Child With Down Syndrome and Disruptive Behaviors

Cohen

Liu²,

Stein³

2010

Journal of Developmental &Amp; Behavioral Pediatrics

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Steve is a 7-year-old child with Down syndrome who was referred to the Developmental and Behavioral Pediatrics Clinic for increasing hyperactivity and disruptive behaviors. He is followed closely for complex congenital heart disease, oxygen dependent pulmonary hypertension and chronic lung disease. He is accompanied by his mother who, while greeting the staff with a smile, apologizes as Steve attempts to get out of his stroller. His mother reports that the pulmonologist requested an evaluation of Steve's disruptive behaviors during recent clinic visits. She states that new people and unfamiliar surroundings cause Steve to become "over-stimulated." He moves around the room, plays with everything available for brief moments, is difficult to examine and difficult to redirect. His mother states that these behaviors are limited to the doctor's office. However, she is even more concerned about his behavior since his recent discharge from the hospital 8 days prior to the clinic visit. Steve was hospitalized for two weeks with a febrile illness associated with pulmonary edema. He required an increase in oxygen and maintenance of his usual medications: digoxin, furosemide, aldactone, an inhaled steroid, levalbuteral, and potassium chloride. During the hospitalization, sildenafil was increased to manage pulmonary hypertension and lorazepam was prescribed for disruptive behaviors. Steve's mother observed that the increase in sildenafil was associated with a significant change in behavior including difficulty following directions, impulsivity and over activity. She worries that he will hurt himself accidentally. Behavioral techniques that were previously helpful at home are no longer are effective. As Steve's mother describes the behaviors, she began to cry. She recently adopted Steve, whom she has cared for since his birth but now confides, "I may have made the wrong decision." She also cares for her biological adult daughter who has Down syndrome. Steve has remained home for several weeks as a result of his physician's recommendations in order to prevent another infectious illness. At home, his mother is struggling with his behaviors and talks about her increasing sense of frustration and anxiety. At the clinic visit, Steve is an active child with physical features typical of Down syndrome. He is wearing a nasal canula with a protective plastic cover, acyanotic and breathing comfortably. He looks at a book and colors on the pages briefly but then loses interest. Steve is in constant motion and interested in exploring the examination room. He particularly likes to climb onto the examination table and look at a mirror while playing with various objects. Steve has limited responsive to redirection. He speaks only a few single words, but he understands simple directions.

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Neurologic, Psychological, and Aggressive Disturbances with Sildenafil

Cited by 3 publications

References 0 publications

Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway

Rewarding properties of sildenafil citrate in mice: role of the nitric oxide-cyclic GMP pathway

Assailants' Sexual Dysfunction During Rape: Prevalence and Relationship to Genital Trauma in Female Victims

A 7-Year-Old Child With Down Syndrome and Disruptive Behaviors

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