2008
DOI: 10.1177/0883073808319070
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Neurological Adverse Events Associated with Antipsychotic Treatment in Children and Adolescents

Abstract: A retrospective cohort design using medical and pharmacy claims from one state's Medicaid program compared incidence rates for neurological adverse events associated with antipsychotic use in 4140 youths prescribed antipsychotic medications and an untreated sample of 4500 youths, January 1998 to December 2005. The treated cohort evinced a higher prevalence of involuntary movements, sedation, and seizures. The odds of incident involuntary movements were significantly higher for those taking aripiprazole, risper… Show more

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Cited by 28 publications
(22 citation statements)
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“…Despite the small sample and the fact that the study was not aimed to investigate drug safety, it should be noted that 7 out of 52 youths experienced side effects, all of which were known and previously reported [33,34]. The fact that 4 cases of suicide attempt or ideation were reported should also be highlighted, even if it is not possible to discriminate between the role of the disease and that of the drugs.…”
Section: Discussionmentioning
confidence: 93%
“…Despite the small sample and the fact that the study was not aimed to investigate drug safety, it should be noted that 7 out of 52 youths experienced side effects, all of which were known and previously reported [33,34]. The fact that 4 cases of suicide attempt or ideation were reported should also be highlighted, even if it is not possible to discriminate between the role of the disease and that of the drugs.…”
Section: Discussionmentioning
confidence: 93%
“…In a retrospective review of South Carolina Medicaid data over a period of 7 years, sedation in youths was greater for ziprasidone, risperidone, quetiapine, and those taking multiple antipsychotics, or in youth also treated with selective serotonin reuptake inhibitors (SSRIs). 28 A review of FDA trial data shows sedation risks of 29% to 89% for risperidone, 25% to 80% for quetiapine, and 44% to 94% for olanzapine.…”
Section: Sedationmentioning
confidence: 99%
“…The main characteristics of the papers are summarized in Supplemental Digital Content Table E2 . The number of published studies grew rapidly since 1999 with one third of the papers ( n = 23, 32.4%) being published within the last 2 years of the review.…”
Section: Resultsmentioning
confidence: 99%