Neurological adverse events post allogeneic hematopoietic cell transplantation: major determinants of morbidity and mortality

Major central nervous system complications after allogeneic stem cell transplantation: A large retrospective study on 888 consecutive adult patients

“…We confirmed that CNS complications are a common event after allo‐SCT, reporting a frequency of 14.2%, in line with the current literature 4‐8 . In one report from 1998, a significantly higher frequency of neurological complications was reported 3 .…”

“…Multivariate regression did not confirm the independent impact of conditioning intensity ( P = .165), most likely explained by the fact that RIC transplantation is mostly used for elderly patients. RIC is an independent risk factor in a recent publication by Sakellari et al 7 that also analyzed a very large monocentric cohort. In contrast to the data demonstrated here, age was not a risk factor in the work by Sakellari et al 7 In addition, the population they analyzed was fairly younger with a median age of 36 years versus 59 years in our analysis, which might explain the contradictory findings 7 .…”

“…We confirmed that CNS complications are a common event after allo-SCT, reporting a frequency of 14.2%, in line with the current literature. [4][5][6][7][8] In one report from 1998, a significantly higher frequency of neurological complications was reported. 3 In this work, the setting was prospective and the authors included peripheral nervous system complications.…”

“…The incidence of CNS complications has been calculated to be between 11% and 56%. [2][3][4][5][6][7][8] Among the possible mechanisms that cause CNS side effects and diseases after allo-SCT, the most common are drug toxicity (calcineurin inhibitors, 9 methotrexate, busulfan, other cytotoxic agents, irradiation, azoles), opportunistic infections, [10][11][12][13][14][15] impairment of metabolic homeostasis due to sepsis or organ failure, and CNS relapse of the underlying malignancy. There is a wide over-…”

Neurologic complications after allogeneic transplantation: a meta‐analysis

“…5 Furthermore, their severity varies from mild to fatal disorders. 4,6 Those complications need to be recognized first by transplanters-hematologists. However, the problem lies in the vast number of various neurologic complications which either have been underestimated or not yet described systematically.…”