Neurological and cognitive long-term outcome in patients with cerebral venous sinus thrombosis

Buccino, Giovanni; Scoditti, Umberto; Patteri, I.; Bertolino, Chiara; Mancia, D

doi:10.1034/j.1600-0404.2003.00031.x

Cited by 62 publications

(53 citation statements)

References 23 publications

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“…CVT 所致的严重视力丧失罕有发生 (2%-4%) [55,193,235 [238][239][240] 。CVT 危险最大的阶段是妊娠晚期和产后最初 4 周 [240] 。在妇女中高达 73% 的 CVT 发生在产褥期 [241] 。剖腹产似乎与经年龄、血管危险因素、感染的存在、医院类型及地点调整后的 CVT 危险增高有关 (OR 3.10, 95% CI 2.26-4.24) [35] 。维生素 K 拮抗剂，包括华法林，与致死性胚胎病和胎儿及新生儿出血有关，因此通常被认为禁用于妊娠期。因此，大多数妇女妊娠期和早期产褥期 CVT 的抗凝治疗为 LMWH [220] 。与 UFH 不同，LMWH 与致畸或胎儿出血危险的增加无关。美国胸科医师学院抗栓指南强调妊娠期和产褥期 DVT 和肺栓塞的预防和治疗，建议 LWMH 优于 UFH [241a] 。他们建议治疗应从妊娠期持续至产后至少 6 周 ( 总的最小疗程为期 6 个月 )。尽管这些建议针对的是系统性静脉血栓，出于若干原因将这些建议应用于 CVT 是符合逻辑的。首先，在致畸和胎儿 / 新生儿 / 母亲出血性并发症方面的安全性应该是相似的；其次，这些建议与非妊娠相关性 CVT 的治疗是一致的。就像对非妊娠妇女一样，溶栓疗法应留给在系统性抗凝治疗下仍有病情恶化的病人，其在妊娠期的应用已有报道 [243] 。未来妊娠和复发与健康个体相比，有既往 VTE 的病人再次发生静脉血栓事件的危险增加 [244,245] 临床结局：预后关于 C V T 的结局和预后有几项研究和综述 [181,256,257] 。这类研究大多数是回顾性的 ( 总的或部分 ) [14,63,66,90,136,175,179,190,194,233,[270][271][272][273][274] 。为数不多的前瞻性研究中，一些研究并没有分析预后因素 [178,193,261] 或仅对这些预测因子做了双变量分析 [275,276] 或仅对特殊病人亚组做了分析 [42,84,89,192] 不能自理 (mRS 评分 ≥ 3 或 Glasgow 预后量表评分 ≥ 3) 的比例是 9.7% [28] 。7 项队列研究 ( 包括资料...…”

Section: 视力丧失unclassified

Diagnosis and Management of Cerebral Venous Thrombosis

Saposnik¹,

Barinagarrementería²,

Brown³

et al. 2011

Stroke

1,697

1,229

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Background— The purpose of this statement is to provide an overview of cerebral venous sinus thrombosis and to provide recommendations for its diagnosis, management, and treatment. The intended audience is physicians and other healthcare providers who are responsible for the diagnosis and management of patients with cerebral venous sinus thrombosis. Methods and Results— Members of the panel were appointed by the American Heart Association Stroke Council's Scientific Statement Oversight Committee and represent different areas of expertise. The panel reviewed the relevant literature with an emphasis on reports published since 1966 and used the American Heart Association levels-of-evidence grading algorithm to rate the evidence and to make recommendations. After approval of the statement by the panel, it underwent peer review and approval by the American Heart Association Science Advisory and Coordinating Committee. Conclusions— Evidence-based recommendations are provided for the diagnosis, management, and prevention of recurrence of cerebral venous thrombosis. Recommendations on the evaluation and management of cerebral venous thrombosis during pregnancy and in the pediatric population are provided. Considerations for the management of clinical complications (seizures, hydrocephalus, intracranial hypertension, and neurological deterioration) are also summarized. An algorithm for diagnosis and management of patients with cerebral venous sinus thrombosis is described.

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Section: 视力丧失unclassified

Diagnosis and Management of Cerebral Venous Thrombosis

Saposnik¹,

Barinagarrementería²,

Brown³

et al. 2011

Stroke

1,697

1,229

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“…1 Some have new seizures after hospital admission. [2][3][4][5][6][7][8][9][10][11] Although such seizures do not have a significant independent influence on long-term prognosis, they may be a cause of early death. 5,11 Risk factors for early seizures, such as motor 9,11 or sensory 5 deficits, cortical vein thrombosis, 11 any brain lesion, 5 or an hemorrhagic brain lesion 11 on admission computed tomography/magnetic resonance imaging (CT/MR), were identified in previous series.…”

mentioning

confidence: 99%

Early Seizures in Cerebral Vein and Dural Sinus Thrombosis

Ferro

Canhão

Bousser

et al. 2008

Stroke

209

117

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MD; for the ISCVT InvestigatorsBackgound and Purpose-The risk of seizure early after the diagnosis of cerebral vein and dural sinus thrombosis (CVT) is not known, and the use of prophylactic antiepileptic (AED) medication in the acute phase of CVT is controversial. Methods-In a multicenter, prospective, observational study, we analyzed the risk factors for seizures experienced before the diagnosis of CVT was confirmed (presenting seizures) or within the following 2 weeks (early seizures). The risk of occurrence of early seizures was compared in 4 risk strata and related to whether patients received AEDs or not. Criteria for the strata were "presenting seizures" and "supratentorial lesions." Results-Two hundred forty-five of 624 (39.3%) patients with CVT experienced presenting seizures, and 43 (6.9%) patients had early seizure.

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“…Headache which was due to increased intracranial pressure was observed in 90% of patients and can be accompanied by other symptoms such as seizure, hemiparesis, and aphasia. 25 The prevalence of headache were 70%, 86.4% and 100% in the studies by Foroghipoor et al 22 Khomand et al 23 and Nikkhah et al 26 respectively. While in the study of Khomand et al 23 Papilledema and blurred vision were the second highest symptom of CVT after headache and in the present study, blurred vision was in the lower rank which was probably due to the lack of examination of patients for Papilledema.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and clinical manifestations of cerebral venous thrombosis in patients admitted to Zahedan city hospitals during 2011-2017

2018

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Background:In Cerebral venous thrombosis (CVT), blood clots are create in the veins and, blood clots may form in the veins or sinuses. In 78% of cases this problem occurred in people lower than 50 years and in women more than men. The annual prevalence of CVT in Iran was 12.3 per one million which was 2.5 times more than world prevalence. Aims and Objective: The aim of this study was to investigate the Risk factors and clinical manifestations of cerebral venous thrombosis in patients admitted to Zahedan city hospitals. Methods and Materials: This retrospective descriptive study was done on 50 patients with CVT which hospitalized in the Zahedan city hospital. Necessary information such as clinical symptoms, risk factors and demographic data extracted from patients file and analyzed by statistical methods in SPSS.16. Results: In this study, 68% of patients were female and 32% were male. The most prevalent season was summer age group 34-43 years constituting about 28 % of the cases. The prevalent season was summer with 38 % cases and headache was the most prevalent symptom (66%). The most prevalent risk factor was infection comprising 30 % of the total patients. Conclusion: Results showed higher prevalence of CVT in women than in men which could be due to the positive relation between prevalence of this disease and risk factors such as oral contraceptive pill (OCP), pregnancy and post-partum period. Also, in this study the most prevalent symptom was headache and the most prevalent season was summer, which could be due to dehydration of patients. The validity of the current study could be further substantiated with study in the similar pattern with more sample size.

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Neurological and cognitive long-term outcome in patients with cerebral venous sinus thrombosis

Abstract: The present study demonstrates a good neurological and cognitive long-term outcome in patients with CVST.

Cited by 62 publications

References 23 publications

Diagnosis and Management of Cerebral Venous Thrombosis

Diagnosis and Management of Cerebral Venous Thrombosis

Early Seizures in Cerebral Vein and Dural Sinus Thrombosis

Risk factors and clinical manifestations of cerebral venous thrombosis in patients admitted to Zahedan city hospitals during 2011-2017

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