Neurological and endocrinological involvement in neonatal lupus erythematosus: a retrospective study at a tertiary hospital in Eastern China

Sun, Wei; Ding, Li; Li, Mengzhao; Fu, Changchang; Yang, Zhen; Zhu, Xueping

doi:10.1007/s10067-023-06622-8

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…Subependymal cysts, increased echogenicity, and hydrocephalus were the most widely seen radiologic changes. Table 3 summarizes the NLE patients in the literature with CNS manifestations ( 8 – 22 ). Psychiatric research and publications not in English are not included in this table.…”

Section: Discussionmentioning

confidence: 99%

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Anti-U1RNP-70kD-positive case of neonatal lupus presenting with seizure and incomplete heart block: a case report and literature review

Alfalasi,

ElGhazali,

Fathalla

et al. 2023

Front. Pediatr.

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Neonatal lupus erythematosus (NLE) is an autoimmune disease caused by the transplacental passage of anti-Ro/SS-A and anti-La/SS-B. This can be less commonly seen with U1-ribonucleoprotein (U1RNP). Our patient is a 7-day-old male, who first presented with seizures. In addition, during an electroencephalogram, he was found to have an irregular heart rhythm. Looking further into the history, we found that the mother was aware that she had systemic lupus erythematosus (SLE). However, she had not been followed up with a rheumatologist. The workup for NLE found a negative anti-Ro/SS-A and anti-La/SS-B, with a positive U1RNP-70kD. U1RNP-70kD is a diagnostic test for mixed connective tissue disease in adults, but no research has been done on its significance in NLE. Despite having SLE, the infant’s mother did not receive surveillance during her pregnancy, as the current guidelines are tailored for mothers with anti-Ro/SS-A and anti-La/SS-B. As a result, this calls for the extension of these guidelines to include the U1RNP-70kD antibody. In this case, the 70kD subtype of U1RNP was positive, which may have had a role to play in this unusual presentation. However, further research is needed to improve the care of mothers and babies with U1RNP-70kD.

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Section: Discussionmentioning

confidence: 99%

“…Psychiatric research and publications not in English are not included in this table. Development of seizure was reported in 10 patients ( 14 , 16 , 17 , 19 , 20 , 22 ), eight of which had an underlying cerebral infarct or hemorrhage. The antibody profile is summarized in Table 3 .…”

Section: Discussionmentioning

confidence: 99%

Anti-U1RNP-70kD-positive case of neonatal lupus presenting with seizure and incomplete heart block: a case report and literature review

Alfalasi,

ElGhazali,

Fathalla

et al. 2023

Front. Pediatr.

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Neonatal lupus erythematosus presenting with effusions: A 13-year retrospective study

Sun,

Jin,

et al. 2024

Clin Rheumatol

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Neonatal lupus erythematosus as a rare trigger of gastrointestinal involvement in neonates

Fu,

Sun,

Peng

et al. 2024

Sci Rep

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Cutaneous and cardiac involvement in neonatal lupus erythematosus (NLE) has been extensively studied; however, gastrointestinal system involvement (GSI) remains unexplored. This study aimed to investigate the clinical features of GSI in patients with NLE with a particular focus on feeding intolerance (FI) and diarrhea. We conducted a retrospective analysis of the clinical data of patients diagnosed with NLE at the Children’s Hospital of Soochow University between 2011 and 2022. In this study, of 39 patients diagnosed with NLE, 27 presented with GSI. 9 patients who presented with FI or diarrhea as the primary manifestation were positive for anti-SSA antibody, and 5 were dual positive for anti-SSA and anti-SSB antibodies. Among the mothers of the NLE patients with GSI, 18 had systemic lupus erythematosus, 3 had Sjogren’s syndrome, 2 had mixed connective tissue disease, and one each had autoantibody abnormalities and photosensitivity symptoms; 4 mothers denied having any autoimmune disease. In this study, 69.23% of patients with NLE exhibited GSI, which was linked to hypocomplementemia and anti-SSA antibodies. Thus, clinicians should remain vigilant for NLE in neonates, particularly when accompanied with rash and other organ dysfunction and when the high-risk factors of FI and diarrhea have been excluded.

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Neurological and endocrinological involvement in neonatal lupus erythematosus: a retrospective study at a tertiary hospital in Eastern China

Cited by 4 publications

References 27 publications

Anti-U1RNP-70kD-positive case of neonatal lupus presenting with seizure and incomplete heart block: a case report and literature review

Anti-U1RNP-70kD-positive case of neonatal lupus presenting with seizure and incomplete heart block: a case report and literature review

Neonatal lupus erythematosus presenting with effusions: A 13-year retrospective study

Neonatal lupus erythematosus as a rare trigger of gastrointestinal involvement in neonates

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