Neurological and neurodevelopmental symptoms in children with familial Mediterranean fever and their siblings

Biro, Oren; Gileles‐Hillel, Alex; Dor-Wollman, Talia; Eisenstein, Eli M.; Berkun, Yackov

doi:10.1007/s00431-021-04286-7

Cited by 4 publications

(3 citation statements)

References 37 publications

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“… 17 In another recent study, the frequency of FS in FMF patients was found to be 9%. 16 Likewise, in the present study, the frequency of FS was found to be higher in patients with FMF than in the normal population. It can be suggested that this increase in frequency develops as a result of high fever during attacks in individuals with a genetic predisposition to FS, rather than being a neurological complication of FMF.…”

Section: Discussionsupporting

confidence: 71%

“…It has been reported that neurological findings such as aseptic meningitis, pseudotumor cerebri, and headache may occur during recurrent polyserositis attacks. 16 FMF attacks are often accompanied by fever, suggesting an increased risk of FS. In a recent study of 97 patients with FMF, 13 patients were found to have a history of FS, which was reported to be significantly higher than in the general population.…”

Section: Discussionmentioning

confidence: 99%

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Increased Frequency of Febrile Seizures in Two Periodic Fever Syndromes: Familial Mediterranean Fever and PFAPA Syndrome

Kılıç¹,

Ozen²,

Barut³

et al. 2022

Turk Arch Pediatrics

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Objective: Our aim in this study is to reveal the frequency of febrile seizures in patients with Familial Mediterranean Fever and Periodic Fever, Aphthous stomatitis, Pharyngitis, cervical Adenitis syndrome and to compare it to normal population. Materials and Methods: Patients with Familial Mediterranean Fever and Periodic Fever, Aphthous stomatitis, Pharyngitis, cervical Adenitis syndrome, who were diagnosed according to Turkish pediatric Familial Mediterranean Fever diagnostic criteria and Marshall criteria, were enrolled to the study. A form containing questions about febrile seizures history was prepared for Familial Mediterranean Fever and Periodic Fever, Aphthous stomatitis, Pharyngitis, cervical Adenitis syndrome patients. Demographic data and febrile seizures history of Periodic Fever, Aphthous stomatitis, Pharyngitis, cervical Adenitis patients were obtained by calling the parents by phone. Familial Mediterranean Fever patients were randomly selected during their routine follow-up. The frequency of febrile seizures in both disease groups was compared with the prevalence of previous febrile seizures studies in the general population in Turkey. Results: A total of 417 Familial Mediterranean Fever and 152 Periodic Fever, Aphthous stomatitis, Pharyngitis, cervical Adenitis subjects were recruited to the study. The frequency of febrile seizures in Familial Mediterranean Fever and Periodic Fever, Aphthous stomatitis, Pharyngitis, cervical Adenitis syndrome was similar (8.4% vs. 8.6%; P > .05). The frequency of febrile seizures in Familial Mediterranean Fever and Periodic Fever, Aphthous stomatitis, Pharyngitis, cervical Adenitis syndrome patients was found to be significantly higher than the frequency in general population (8.4% vs. 4.4%) [ P < .0001, OR: 1.99 (CI: 1.4-2.8)]; (8.6% vs. 4.4%) [ P < .01, OR: 2.03 (CI: 1.1-3.6)], respectively. Conclusion: The frequency of febrile seizures in patients with Familial Mediterranean Fever and Periodic Fever, Aphthous stomatitis, Pharyngitis, cervical Adenitis syndrome was found to be significantly higher than in the general population. This increased frequency of febrile seizures in both periodic syndromes seems to be a result of recurrent fever.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Increased Frequency of Febrile Seizures in Two Periodic Fever Syndromes: Familial Mediterranean Fever and PFAPA Syndrome

Kılıç¹,

Ozen²,

Barut³

et al. 2022

Turk Arch Pediatrics

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“…A previous study reported that the prevalence of neurological manifestations in pediatric cases was 12.8%. 14 In a recent study, Biro et al 15 compared the neurological complaints of children with FMF and their healthy siblings and it was found that neurological manifestations were more prevalent in cases. As compatible with our results, in a study conducted in our country, Canpolat et al 10 searched neurological signs and symptoms in 104 children and reported the prevalence of neurological manifestations as 21.5% in the study group.…”

Section: Discussionmentioning

confidence: 99%

Neurological Face of Familial Mediterranean Fever

Cetın

Yarar

Çarman

2022

Turk Arch Pediatrics

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Objective: Familial Mediterranean fever is a systemic inflammatory disease characterized by recurrent attacks in the form of fever and inflammation of serous membranes. We aimed to search for neurological signs and symptoms of children with familial Mediterranean fever. Materials and Methods: Medical records database from 2010 to 2020 was screened retrospectively. In total, 625 children with familial Mediterranean fever were included in the study. Neurological symptoms and associated factors were searched. Results: The mean age at onset of familial Mediterranean fever symptoms and time to diagnosis was calculated as 5.12 ± 3.51 years and 7.27 ± 3.9 years, respectively. The neurological symptoms were present in 142 (23.5%) patients. Headache was the most common symptom. During follow-up, different neurologic diseases were diagnosed in 40 familial Mediterranean fever patients and epilepsy was the most frequent disease. The coexistent disease was present in 49.9% of children with familial Mediterranean fever. Juvenile idiopathic arthritis was found to be a risk factor for the neurologic symptom ( P < .05). The frequency of neurological symptoms was higher in patients with E148Q mutation ( P < .012). Conclusion: The results of the present study revealed that patients with familial Mediterranean fever can present with various central nervous system manifestations. A multidisciplinary approach must be considered in the treatment of these children.

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A preliminary study: relationship between inattention/hyperactivity and familial mediterranean fever in children and adolescents

Durcan

Barut

Haşlak

et al. 2022

Child Neuropsychology

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Neurological and neurodevelopmental symptoms in children with familial Mediterranean fever and their siblings

Cited by 4 publications

References 37 publications

Increased Frequency of Febrile Seizures in Two Periodic Fever Syndromes: Familial Mediterranean Fever and PFAPA Syndrome

Increased Frequency of Febrile Seizures in Two Periodic Fever Syndromes: Familial Mediterranean Fever and PFAPA Syndrome

Neurological Face of Familial Mediterranean Fever

A preliminary study: relationship between inattention/hyperactivity and familial mediterranean fever in children and adolescents

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