Neurological and Neurophysiological Findings in Workers with Chronic 2,3,7,8‐Tetrachlorodibenzo‐<i>p</i>‐Dioxin Intoxication 50 Years After Exposure

Pelclová, Daniela; Urban, Pavel; Fenclová, Zdeňka; Vlčková, Štěpánka; Ridzoň, Petr; Kupka, Karel; Mecková, Zuzana; Bezdíček, Ondřej; Navrátil, Tomáš; Rosmus, Jan; Zakharov, Sergey

doi:10.1111/bcpt.12899

Cited by 13 publications

(5 citation statements)

References 33 publications

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“… 159 Tetrachloro-dibenzofuran Chlorinated dioxin Xu et al [ 394 ]: this dioxin-like compound suppresses acetylcholinesterase activity via transcriptional downregulations in vitro. 160 Tetrachloro-dibenzo-p- dioxin Chlorinated dioxin Pelclova et al [ 395 ]: neurological and neurophysiological findings in workers with chronic intoxication 50 years after exposure. Xu et al [ 394 ]: this dioxin suppresses acetylcholinesterase activity via transcriptional downregulations in vitro.…”

Section: Resultsmentioning

confidence: 99%

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Séralini

Jungers

2021

Toxicology Reports

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Section: Resultsmentioning

confidence: 99%

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Séralini

Jungers

2021

Toxicology Reports

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“…Vascular dysfunction was observed in these subjects in 2004 . In addition, this group of patients showed severe neurological and neuropsychological impairment throughout the following years .…”

mentioning

confidence: 88%

“…8 and No. 1, respectively . This made them one of the most severely intoxicated groups of subjects in the world among herbicide producers and users in several countries, including veterans of the war spraying TCDD‐contaminated Agent Orange in Vietnam and the associated affected Vietnamese population .…”

mentioning

confidence: 99%

Diabetes, Cardiovascular Disorders and 2,3,7,8‐Tetrachlorodibenzo‐p‐Dioxin Body Burden in Czech Patients 50 Years After the Intoxication

Pelcl

Škrha

Prázný

et al. 2018

Basic Clin Pharma Tox

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The correlation between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication and the parameters of metabolic impairment was examined in the last eight male survivors of 80 workers exposed to TCDD during the production of herbicides in a chemical factory in 1965-1967. Their median TCDD blood level was 112 (46-390) pg/g lipids, and the median TCDD body deposit was 3.9 (0.8-11.7) μg. This puts these patients into the most severely intoxicated group of subjects, according to back-calculated levels of TCDD. The median TCDD blood level in eight controls was 12 pg/g (<0.10 to 22.2 pg/g). Markers of metabolic impairment - diabetes, dyslipidaemia, arterial hypertension, carotid artery plaque, skin microvascular reactivity, eye fundus hypertensive angiopathy and history of coronary heart disease - were assessed and compared to a general male population of comparable age. Measured parameters compared with a population of comparable age were as follows: prevalence of diabetes (62.5% versus 17.6%), arterial hypertension (87.5% versus 71.8%), dyslipidaemia (87.5% versus 88.8%), history of coronary heart disease (62.5% versus 26.0%) and eye fundus hypertension angiopathy (50% versus 14%). All eight patients (100% versus 43%) developed plaques in carotid arteries, six had stenosis >50% and two had a carotid intervention (stenting or endarterectomy). Total cholesterol levels decreased compared to the earlier study this patient group in 2008, most likely due to a more intensive use of lipid-lowering drugs. Several metabolic parameters were higher (diabetes as much as 3.5-fold) in the group of severely TCDD-intoxicated subjects than in a general population of comparable age. This suggests that TCDD plays a role in the development of metabolic impairment and vascular changes.

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“…Patients had on average 2.5 perfusion defects, which were predominantly located in the region of the middle cerebral artery. In a followup study, the last eight survivors of this cohort were investigated again 50 years after the exposure to TCDD (Pelclova et al 2018). All subjects showed impairment in neurological tests, and four subjects showed clinical signs of polyneuropathy and two subjects of mononeuropathy in the upper extremities.…”

Section: Dioxins and Pcbsmentioning

confidence: 99%

PET and SPECT Imaging of Neurotoxicity

Vries¹,

Dierckx²,

Groot³

2020

PET and SPECT in Neurology

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Neurological and Neurophysiological Findings in Workers with Chronic 2,3,7,8‐Tetrachlorodibenzo‐p‐Dioxin Intoxication 50 Years After Exposure

Cited by 13 publications

References 33 publications

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Diabetes, Cardiovascular Disorders and 2,3,7,8‐Tetrachlorodibenzo‐p‐Dioxin Body Burden in Czech Patients 50 Years After the Intoxication

PET and SPECT Imaging of Neurotoxicity

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