Neurological comorbidity and epilepsy: implications for treatment

Zaccara, Gaetano

doi:10.1111/j.1600-0404.2008.01146.x

Cited by 36 publications

(29 citation statements)

References 109 publications

(153 reference statements)

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“…This can affect significantly the prognosis, the quality of life and the treatment. Epilepsy and the use of AEDs can also affect these associated conditions 41,42 . Hanssen-Bauer et al 42 investigated the occurrence of psychiatric disorders in 74 children and adolescents referred to a tertiary epilepsy center in Norway and found 77% with possible or probable associated psychiatric disorders.…”

Section: Epilepsy and Neuropsychiatric Comorbiditiesmentioning

confidence: 99%

Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to the treatment

Koneski

Casella

2010

Arq. Neuro-Psiquiatr.

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The association between attention deficit and hyperactivity disorder (ADHD) and epilepsy can cause significant impact on the social life of affected individuals and their families. Clinical studies suggest that 30-40% of people with epilepsy also have ADHD. There are no studies which demonstrate that short or long-term treatment with methylphenidate increases the risk of seizures. Some studies attempt to relate drug interactions between methylphenidate and antiepileptic drugs, but adverse effects of methylphenidate have not been shown clearly. This review presents some neurobiological and physiopathogenic aspects, common to ADHD and epilepsy, from recent research studies, related to pharmacology, neuroimaging and electroencephalography. Possible risk of occurrence of seizures associated with the use of methylphenidate are also discussed. Key words: ADHD, epilepsy, methylphenidate, comorbidities, seizures, antiepileptic drugs.Transtorno de déficit de atenção e hiperatividade em pessoas com epilepsia: diagnóstico e implicações para o tratamento RESUMO A associação entre transtorno de déficit de atenção / hiperatividade (TDAH) e epilepsia pode causar importante impacto na vida social dos indivíduos afetados e seus familiares. Estudos clínicos sugerem que 30-40% das pessoas com epilepsia também apresentam TDAH. Não existem publicações que evidenciem que o tratamento a curto ou longo prazo com metilfenidato aumente o risco de ocorrência de crises epilépticas, e alguns estudos procuram relacionar as interações medicamentosas entre o metilfenidato e as drogas antiepilépticas, porém não foram demonstrados os possíveis efeitos do metilfenidato de uma maneira clara. Apresenta-se a seguir, revisão sobre os aspectos neurobiológicos e fisiopatogênicos comuns ao TDAH e epilepsia, a partir de pesquisas recentes relacionadas a estudos de farmacologia, neuroimagem e eletroencefalografia, e discuti-se os possíveis riscos da ocorrência de crises epilépticas associadas ao uso de metilfenidato.

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Section: Epilepsy and Neuropsychiatric Comorbiditiesmentioning

confidence: 99%

Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to the treatment

Koneski

Casella

2010

Arq. Neuro-Psiquiatr.

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“…Verschiedene Antiepileptika führen zu Lipidwertveränderungen im Serum, die als atherogen gelten [107]. Besonders bei enzyminduzierenden Antiepileptika, aber auch bei VPA wird eine Erhöhung der Serumlipide beschrieben [30,85].…”

Section: Lipide Im Serumunclassified

Laboratory monitoring in the pharmacotherapy of epilepsy

Fröscher

Steinhoff

2011

Z. Epileptol.

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“…Therefore, consideration needs to be given to the choice of antiepileptic drug (AED), which may positively or negatively af fect any of these comorbidities; drugs used in the treatment of the comorbidity, which may influence seizure control, AED toxicity or total drug load; and the co-administration of AEDs with drugs used in the treatment of comorbid conditions, which may be associated with clinically relevant drug interactions. 3 Depression is common in epilepsy, but is often under-recognised and therefore also undertreated. It is associated with a poor quality of life and may worsen the epilepsy.…”

Section: Epilepsy Comorbiditiesmentioning

confidence: 99%

Seizure control is important: but don't forget the patient

Johnston¹

2010

Prog Neurol Psychiatry

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Control of epileptic seizures is not the only issue facing patients with epilepsy: they often suffer a range of comorbidities that affect quality of life as much as the seizures themselves. Dr Johnston explains how involving a wider multidisciplinary team of professionals in the management of patients with epilepsy can significantly improve patients' well‐being and quality of life. Copyright © 2010 Wiley Interface Ltd

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Neurological comorbidity and epilepsy: implications for treatment

Cited by 36 publications

References 109 publications

Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to the treatment

Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to the treatment

Laboratory monitoring in the pharmacotherapy of epilepsy

Seizure control is important: but don't forget the patient

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