1999
DOI: 10.1038/sj.bmt.1701969
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Neurological complications after stem cell transplantation in childhood

Abstract: Summary:We analyzed the incidence of neurological complications in 77 patients receiving stem cell transplantation (SCT), and 12 patients (15.8%) had the following symptoms: convulsions, intracranial hemorrhage, and leukoencephalopathy. Although statistically not significant, neurological complications were seen more frequently in patients after allogeneic transplantation, and in those with acute graft-versus-host disease (GVHD) exceeding grade II. The most significant risk factor for neurological complication… Show more

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Cited by 57 publications
(80 citation statements)
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“…1,3,5 In this study, neurological complications were seen more frequently in mismatched transplant recipients and in those with 4grade II GvHD. Corticosteroids used during treatment of GvHD are known to influence CsA levels [4][5][6] and may thus contribute to the development of neurological events.…”
Section: Discussionmentioning
confidence: 52%
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“…1,3,5 In this study, neurological complications were seen more frequently in mismatched transplant recipients and in those with 4grade II GvHD. Corticosteroids used during treatment of GvHD are known to influence CsA levels [4][5][6] and may thus contribute to the development of neurological events.…”
Section: Discussionmentioning
confidence: 52%
“…1,2,5,6 In patients with sickle cell disease with a previous history of stroke, neurological complications have been reported to occur in 50% of the patients during the transplant period. 12 In addition, 90% of autopsies performed in BMT patients have revealed neuropathological findings.…”
Section: Discussionmentioning
confidence: 99%
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