2011
DOI: 10.1016/j.ymgme.2011.07.015
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Neurological complications and behavioral problems in patients with phenylketonuria in a Follow-up Unit

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Cited by 38 publications
(47 citation statements)
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“…Of 17 studies reporting psychiatric symptoms in adults with PKU, the 10 reporting prevalence of inattention, hyperactivity, anxiety, or depression were included in the MA (Anjema et al, 2011; Brumm et al, 2004;Campistol, González, Gutiérrez, & Vilaseca, 2012;Fisch et al, 1995;González et al, 2011;Kalkanoğlu et al, 2005;Koch et al, 2002;Pietz, Fatkenheuer, Armbruster, Esser, & Schmidt, 1997;Ris et al, 1997;Schuett et al, 1985). Of 19 studies reporting neurologic symptoms, the 10 reporting prevalence of both epilepsy/seizures and tremors were included in the MA (Campistol et al, 2012;Crowley, Koch, Fishler, Wenz, & Ireland, 1990;González et al, 2011;Leuzzi, Bianchi, Tosetti, Carducci, & Antonozzi, 2000;Leuzzi, Trasimeni, Gualdi, & Antonozzi, 1995;McDonnell, Esmonde, Hadden, & Morrow, 1998;Pfaendner et al, 2005;Pitt & Danks, 1991;Schuett et al, 1985;Thompson et al, 1993).…”
Section: Meta-analysis: Neuropsychiatric Symptomsmentioning
confidence: 99%
See 1 more Smart Citation
“…Of 17 studies reporting psychiatric symptoms in adults with PKU, the 10 reporting prevalence of inattention, hyperactivity, anxiety, or depression were included in the MA (Anjema et al, 2011; Brumm et al, 2004;Campistol, González, Gutiérrez, & Vilaseca, 2012;Fisch et al, 1995;González et al, 2011;Kalkanoğlu et al, 2005;Koch et al, 2002;Pietz, Fatkenheuer, Armbruster, Esser, & Schmidt, 1997;Ris et al, 1997;Schuett et al, 1985). Of 19 studies reporting neurologic symptoms, the 10 reporting prevalence of both epilepsy/seizures and tremors were included in the MA (Campistol et al, 2012;Crowley, Koch, Fishler, Wenz, & Ireland, 1990;González et al, 2011;Leuzzi, Bianchi, Tosetti, Carducci, & Antonozzi, 2000;Leuzzi, Trasimeni, Gualdi, & Antonozzi, 1995;McDonnell, Esmonde, Hadden, & Morrow, 1998;Pfaendner et al, 2005;Pitt & Danks, 1991;Schuett et al, 1985;Thompson et al, 1993).…”
Section: Meta-analysis: Neuropsychiatric Symptomsmentioning
confidence: 99%
“…Of 19 studies reporting neurologic symptoms, the 10 reporting prevalence of both epilepsy/seizures and tremors were included in the MA (Campistol et al, 2012;Crowley, Koch, Fishler, Wenz, & Ireland, 1990;González et al, 2011;Leuzzi, Bianchi, Tosetti, Carducci, & Antonozzi, 2000;Leuzzi, Trasimeni, Gualdi, & Antonozzi, 1995;McDonnell, Esmonde, Hadden, & Morrow, 1998;Pfaendner et al, 2005;Pitt & Danks, 1991;Schuett et al, 1985;Thompson et al, 1993). Table 3 presents MA results that show higher than expected prevalence estimates for neuropsychiatric symptoms in adults with PKU (based on clinical observation) when compared with prevalence estimates (based on a structured diagnostic interview) established by the U.S. National Comorbidity Survey Replication (Kessler, Chiu, Demler, & Walters, 2005).…”
Section: Meta-analysis: Neuropsychiatric Symptomsmentioning
confidence: 99%
“…High Phe concentration can impair brain function even in early-treated PKU patients, who have shown poor cognitive function (Gonzalez et al 2011;Weglage et al 2013;Jahja et al 2014). Although the mechanisms are not yet fully understood, oxidative stress and brain amino acid imbalance caused by high Phe levels are speculated to underlie the impaired clinical outcomes.…”
Section: Introductionmentioning
confidence: 99%
“…Lack of tyrosine leads to low neurotransmitter levels such as dopamine and serotonin [3]. Persistently elevated phe and reduced tyrosine levels can cause a multitude of clinical and subclinical effects, including physical and psychological effects (cognitive, emotional and behavioral) [1,4,5]. While some health consequences of persistently elevated phe levels in PKU are reversible, others are not [6].…”
Section: Introductionmentioning
confidence: 99%