Neurological complications of anorexia nervosa

Abstract

We would like to point out a preliminary study which investigated the effects of cholesterol-reducing agents on the serotonin-related behaviour in vivo (Dursun, 1992). Rather high doses of cholesterol-lowering agents, gemfibrozil and cholestyramine, both significantly blocked the inhibitory action of a serotonin-lA receptor agonist ligand on the serotonin-2 receptor mediated-behavioural response (head-shakes), while gemfibrozil significantly potentiated this behavioural response and cholestyramine showed a trend towards potentiation of the same behaviourin rodents (signifi cantly low plasma cholesterol levels compared with control animals have been confirmed by biochemical studies after behavioural studies) (Dursun, 1992). These preliminary results show that cholesterol lowering agents can indeed alter both serotonin-2 receptor-mediated behaviour and a serotonin-1A/ serotonin-2 receptor interaction in vivo. Therefore, alterations of the functional state of the serotonin receptor subtypes and their interactions by the cholesterol-lowering agents may be implicated in understanding the involvement of serotonin in the relationship between low serum cholesterol and suicidal behaviour. However, further precliical and clinical research is needed to understand the mechanisms of this relationship.

Ten‐year follow‐up of adolescent‐onset anorexia nervosa: physical health and neurodevelopment

“…A wide range of neurological abnormalities have been reported in AN (myopathy, neuropathy, neurogenic stutter, seizures, bilateral foot-drop) (Shur et al 1988, Byrne et al 1993, Patchell et al 1994, Woodruff et al 1994, Lacomis 1996, Kershenbaum et al 1997. Most neurological complications appear to occur as a consequence of electrolyte, metabolic, and nutritional disturbances secondary to AN (Patchell et al 1994).…”

From Prison to Society

“…Historian Paula J. Byrne undertook an extensive qualitative study of them, though despaired of using them to construct a complete database of colonial crime due to "the 'grey area' of crimes, which do not appear before the courts". 41 She therefore eschewed the effort entirely.…”