Neurological complications of COVID-19

Headache and cognitive disturbance correlate with ganglion cell layer thickness in patients who recovered from COVID-19

“…However, GCLT was already and significantly lower in the patients who suffered from headache and those who had cognitive symptoms after acute illness, implying central neurological involvement. The observed change in the GCLT values of this specific group of COVID-19 patients may support the trans-neuronal route of virus dissemination towards central nervous system [9] . In a recent review, a possible pathophysiological mechanism for long COVID symptoms was proposed to be olfactory sensory neuronal damage leading to glymphatic circulatory failure in the brain [23] .…”

“…These findings are important from a neurological perspective, since retina can be described as an outgrowth of the brain, and the fact that transsynaptic spread is proposed to be a dissemination pathway for SARS-CoV-2 [9] . Studies showing retinal abnormalities in COVID-19 patients are being increasingly reported in the literature [10] , [11] , [12] , [13] .…”

Long‐term side effects and lingering symptoms post COVID‐19 recovery

“…49 Most recent reviews give more detailed mechanisms and complications of the Neuro COVID. [49][50][51][52] A retrospective cohort study of 6-month neurological and psychiatric outcome in 236,379 COVID-19 survivors along with 2 control cohort of 105,579 patients diagnosed with influenza and 236,038 patients diagnosed with respiratory tract infection has been recently published. 29 The COVID-19 cohort was further divided into and not attributable to alternative diagnosis.…”

“… 49 Most recent reviews give more detailed mechanisms and complications of the Neuro COVID. 49 , 50 , 51 , 52 …”

“…Peripheral nervous system (PNS) manifestations have also been reported including neuropathic pain, skeletal muscle injury and hyperCKaemia, Guillain‐Barré syndrome, cranial polyneuritis, neuromuscular junction disorders, neuro‐ophthalmological disorders, neurosensory hearing loss and dysautonomia 49 . Most recent reviews give more detailed mechanisms and complications of the Neuro COVID 49–52 …”