Neurological Complications of the COVID-19 Pandemic: What Have We Got So Far?

Bandeira, Isabelle Pastor; Schlindwein, Marco Antônio Machado; Breis, Letícia Caroline; Peron, Jean Pierre Schatzmann; Gonçalves, Marcus Vinícius Magno

doi:10.1007/978-3-030-59261-5_2

Cited by 10 publications

(7 citation statements)

References 60 publications

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“…Развитие патологии периферической нервной системы и ЦНС также связано с системным васкулитом, тромбоэмболическими осложнениями на уровне мелких и крупных сосудов, дисбалансом РААС и системной гиперпродукцией цитокинов. Последствиями этого могут стать демиелинизирующие процессы (в частности имеются описания синдрома Гийена -Барре), очаговые некрозы нейронов, функциональные сенсорные, нейромышечные и когнитивные нарушения [18][19][20].…”

Section: последствия инфекции Sars-cov-2unclassified

“Post-COVID syndrome”: The focus is on musculoskeletal pain

Каратеев¹,

Амирджанова²,

Насонов

et al. 2021

Naučno-praktičeskaâ revmatologiâ

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Combating the consequences of COVID-19, a disease caused by the new coronavirus infection SARS-CoV-2, is a serious and very urgent task facing modern medicine. COVID-19 often has a severe course and is accompanied by multiple organ damage, systemic immune inflammation, coagulopathy, neuroendocrine and metabolic disorders. Even with a relatively favorable course, the consequences of SARS-CoV-2 infection can be degenerative changes in many organs (pulmonary fibrosis, cardiosclerosis), various functional and psychoemotional disorders. As a result, in 10–50% of patients, various unpleasant symptoms persist for a long time after the acute manifestations of COVID-19 subside and the virus is eliminated. This pathology is referred to as “post-COVID syndrome” (PCS). The main elements of PCS are chronic pain, fatigue, and psychoemotional problems. Functional disorders, autoimmune processes, and severe psychological distress after COVID-19 can cause the development and exacerbation of diseases characterized by chronic pain and fatigue, such as fibromyalgia and chronic fatigue syndrome. Therapy and prevention of PCS include correction of functional disorders, pain control, and consistent physical, psychological, and social rehabilitation.

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Section: последствия инфекции Sars-cov-2unclassified

“Post-COVID syndrome”: The focus is on musculoskeletal pain

Каратеев¹,

Амирджанова²,

Насонов

et al. 2021

Naučno-praktičeskaâ revmatologiâ

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“…Autoimmune encephalitis represents a rare but potentially treatable cause of psychotic and affective disorders and may be triggered by viral infections such as those caused by SARS-CoV-2. Although the mechanism is not precisely known, SARS-COV-2 infection of the brain appears to occur via retrograde transmission from the olfactory bulb or transport through a disrupted BBB ( 61 ), or it could occur indirectly in the sequelae of the cytokine storm effects ( 62 ). In all of these scenarios, the overproduction of inflammatory cytokines results in BBB disruption, allowing the further invasion of the brain by cytokines, monocytes and CD4+ lymphocytes bearing the virus.…”

Section: Summary Conclusion and Future Prospects For Precision Psychiatrymentioning

confidence: 99%

Section: Summary Conclusion and Future Prospects For Precision Psychiatrymentioning

confidence: 99%

“…The most common manifestations include fatigue and headache, although there is two-fold increased risk of developing a neuropsychiatric disorder after a COVID-19 diagnosis (63,64). Autoimmune inflammation, such as Guillain-Barre syndrome or NMDAR encephalitis are described only in isolated cases and the causal association with SARS-CoV-2 is subject to conjecture at this time (5,61). Given the importance the potential role of viruses in the pathophysiology of neuropsychiatric illnesses such as autoimmune-encephalitis, it is critical that a correct diagnosis is made to allow the most appropriate treatment.…”

Section: Summary Conclusion and Future Prospects For Precision Psychiatrymentioning

confidence: 99%

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Potential Cross-Links of Inflammation With Schizophreniform and Affective Symptoms: A Review and Outlook on Autoimmune Encephalitis and COVID-19

et al. 2021

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Based on current implications of the SARS-CoV-2 pandemic with regards to mental health, we show that biological links exist between inflammation and mental illness in addition to psychoreactive effects. We describe key principles of the biological interaction of the immune system and the mind, as well as the possible routes of viral entry into the brain. In addition, we provide a stepwise scheme for the diagnosis and therapy of autoimmune-encephalitis with schizophrenia-like symptomatology as a general guide for clinical practice and in the specialized scenario of infections, such as those caused by the SARS-CoV-2 virus.

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“…Помимо прямого действия SARS-CoV-2, поражение нервной системы определяется васкулитом, тромбоэмболическими осложнениями на уровне мелких и крупных сосудов (в том числе развитием ишемического инсульта), нарушениями РААС и влиянием системной воспалительной реакции. Последствиями «нейроинвазии» на фоне COVID-19 становятся демиелинизирующие процессы (описаны случаи развития синдрома Гийена -Барре), очаговые некрозы нейронов, функциональные, сенсорные, нейромышечные и когнитивные нарушения [12][13][14]. Важную роль в развитии ПКС отводят дисфункции автономной (вегетативной) нервной системы, с которой связывают появление таких симптомов, как ортостатическая гипотензия, сердцебиение, ощущение перебоев в сердце, одышка, головокружение и др.…”

Section: ревматологияunclassified

Chronic Musculoskeletal Pain Associated with a Previous SARS-CoV-2 Infection

Каратеев¹,

Scientific²,

Лила³

et al. 2021

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Objective of the Review: To describe the problem of chronic musculoskeletal pain associated with a previous SARS-CoV-2 infection. Key Points. COVID-19 is a disease caused by the novel coronavirus infection SARS-CoV-2, characterised by multiple organ damage, systemic immune inflammation, coagulopathy, and serious neuroendocrine and metabolic disorders. The consequences of COVID-19, even with a relatively favourable course of this disease, can be degenerative changes in many organs (primarily, diffuse fibrosis), various functional and mental disorders. Therefore, in some patients (10% to 50%, depending on the severity of the course of COVID-19), various symptoms of the disease persist for a long time after the acute manifestations of the infection subside. This condition has been called “post-COVID syndrome” (PCS), or “long-term COVID-19”. One of the main manifestations of PCS is musculoskeletal pain, weakness and fatigue. COVID-19-induced damage to the musculoskeletal and nervous systems can contribute to the exacerbation of diseases characterised by chronic pain. PCS management should be aimed at correcting functional disorders, pain control, and active rehabilitation of patients. Conclusion. Chronic pain is one of PCS manifestations that requires special attention, timely diagnosis, and comprehensive individual therapy. Keywords: COVID-19, post-COVID syndrome, musculoskeletal pain.

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Neurological Complications of the COVID-19 Pandemic: What Have We Got So Far?

Cited by 10 publications

References 60 publications

“Post-COVID syndrome”: The focus is on musculoskeletal pain

“Post-COVID syndrome”: The focus is on musculoskeletal pain

Potential Cross-Links of Inflammation With Schizophreniform and Affective Symptoms: A Review and Outlook on Autoimmune Encephalitis and COVID-19

Chronic Musculoskeletal Pain Associated with a Previous SARS-CoV-2 Infection

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