Neurological diagnoses in hospitalized <scp>COVID</scp>‐19 patients during the B.1.1.529 surge

Kim, Carla Y.; Sardar, Zomer; Ayele, Biniyam A.; Fleck-Derderian, Shannon; Barrett, Chris; Sun, Yifei; Clague, Madison; Hurst, Holly A; Boruah, Abhilasha P; Zucker, Jason; Maddox, Ryan A.; Sejvar, James J.; Thakur, Kiran T.

doi:10.1002/acn3.51833

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…Among younger individuals, a rise in neurologic symptoms, such as altered mental status and seizures, was also observed when the Omicron variant emerged ( 18 , 19 ). This is consistent with the findings of another study, which stratified subjects into pre-Omicron and post-Omicron surge groups and demonstrated that encephalopathy is the most common neurologic diagnosis among both variants ( 11 ). The frequency of stroke and seizure was higher among post-Omicron surge patients compared to pre-Omicron patients ( 11 ).…”

Section: Discussionsupporting

confidence: 91%

“…This is consistent with the findings of another study, which stratified subjects into pre-Omicron and post-Omicron surge groups and demonstrated that encephalopathy is the most common neurologic diagnosis among both variants ( 11 ). The frequency of stroke and seizure was higher among post-Omicron surge patients compared to pre-Omicron patients ( 11 ). Our study was conducted during the pre-Omicron and Omicron waves and demonstrated that approximately 30% of patients with a stroke died in the hospital.…”

Section: Discussionsupporting

confidence: 91%

“…Milder neurological symptoms, such as headache or diminished or loss of taste or smell, have been found to have a lower risk of in-hospital mortality ( 9 ). Furthermore, COVID-19-infected patients diagnosed after the emergence of the Omicron variant demonstrated lower disease severity and in-hospital mortality rates ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

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Hospital outcomes of acute COVID-19 infection among patients with neurological conditions: a single-center study

Desouky,

Fuentes,

Tiwari

et al. 2024

Front. Neurol.

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BackgroundCoronavirus disease 2019 (COVID-19) infection has been associated with severe neurological consequences, including stroke or seizures, and less severe neurological sequelae, including headaches, dizziness, and anosmia. Earlier COVID-19 variants were associated with high morbidity and mortality; however, knowledge of the impact of neurological conditions in the setting of COVID-19 on healthcare outcomes is limited. We sought to determine the impact of acute neurological conditions and acute COVID-19 infection on inpatient hospitalization outcomes.MethodsThis was a retrospective, observational study of adult patients who were admitted to a large academic medical center in the Southeastern US between April 2020 and December 2021 with acute COVID-19 infection and a neurological diagnosis. Patient demographics, medical history, neurological diagnoses, and hospitalization outcomes were obtained from the medical record. Descriptive statistics and unadjusted and adjusted logistic regression analyses were performed.ResultsOf the 1,387 patients included in this study, 27% died and 23% were kept under ventilation during hospitalization. The mean +/− standard deviation (SD) age was 64.6+/−16.9 years, with 52.8% women and 30.1% identifying as Black/African American. The most common neurological conditions included ischemic stroke (35.0%), movement disorder (12.0%), and hemorrhagic stroke (10.7%). In-hospital death was most common among those with epilepsy (p = 0.024), headache (p = 0.026), and dementia (p < 0.0001) compared to individuals without those conditions. Ventilation support was given more commonly to dementia patients (p = 0.020). Age was a significant risk factor for death (p < 0.001) and hospital length of stay (LOS) for ventilation (p < 0.001), but no neurological condition was a significant factor in adjusted logistic regression analyses.DiscussionMortality was high in this study, with more than one-quarter of patients dying in the hospital. Death was the most common among those with epilepsy, headache, or dementia, but no neurological condition increased the risk of in-hospital mortality or ventilation. Future studies would determine the long-term neurological sequelae of those discharged from the hospital with COVID-19 and a neurological condition.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

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Hospital outcomes of acute COVID-19 infection among patients with neurological conditions: a single-center study

Desouky,

Fuentes,

Tiwari

et al. 2024

Front. Neurol.

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“…Between 2021 and 2023, a total of 61 manuscripts were authored by our alumni, including 27 original research articles, 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 16 case reports, 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 2 perspective pieces, 50 51 3 review articles, 52 53 54 1 book chapter, 55 1 association statement, 56 1 consensus statement, 57 1 data note, 58 and 8 that were published on a preprint server (not peer reviewed). 59 60 61 62 63 64 65 Of these academic contributions, 19 of these papers were published in journals with an impact factor of 3.0 to 10.0.…”

Section: Impact Of the Neurology Training Programmentioning

confidence: 99%

Neurology Training and Medical Education in Resource-Limited Settings: Building and Growing the First Neurology Residency Program in East Africa

Belay,

Gebrewold,

Ayele

et al. 2024

Semin Neurol

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The burden of neurological disease disproportionately affects low- and middle-income countries, where the lowest number of neurologists are located. Building local training opportunities in resource-limited settings is a foundational step to enhancing the neurological workforce and improving access to neurological care in these regions. In this article, we describe the development and growth of the first neurology residency program in East Africa, which was established in 2006 at Zewditu Memorial Hospital and the Tikur Anbessa Specialized Hospital, Addis Ababa University, Ethiopia. We highlight the impact of the program on clinical care, research, collaborations between neurologists across Ethiopia, and ways to build educational opportunities and mentorship while faced with limited resources. The main challenges in starting the residency program included lack of faculty with neurological expertise, lack of a precedent for subspecialty training in our setting, as well as limited resources and space. The formation of sustainable international collaborations with clinicians at established institutions in high-income countries and neurological societies has been a major source of support in developing the initial infrastructure, curriculum and educational content, knowledge assessments, and mentored research projects. Local partnerships with related medical specialties, including internal medicine, critical care, neurological surgery, and psychiatry, were also instrumental in creating training opportunities. As the program continues to evolve, many challenges remain, including limited diagnostics, lack of access to advanced treatment modalities, lack of fellowship training opportunities in various neurological subspecialties, and insufficient training and experience in scientific writing. Despite these challenges, the residency program has persevered and its creation resulted in many positive changes: since its inception in 2006, we graduated 80 neurologists and the number of practicing neurologists in Ethiopia has increased from 5 to 78, our institution has evolved into a national referral center for neurology, graduates have published 61 articles in the past 3 years and contributed to international neurology research, and alumni of the program have grown the Association of Ethiopian Neurologists. Future directions include development of fellowship opportunities, creation of international rotations, and implementation of teleneurology to further strengthen neurological care across Ethiopia.

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Omicron variant (B.1.1.529) challenge the integrity of blood brain barrier: Evidence from protein structural analysis

Nasir,

Samad,

Ullah

et al. 2024

Computers in Biology and Medicine

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Neurological diagnoses in hospitalized COVID‐19 patients during the B.1.1.529 surge

Cited by 3 publications

References 32 publications

Hospital outcomes of acute COVID-19 infection among patients with neurological conditions: a single-center study

Hospital outcomes of acute COVID-19 infection among patients with neurological conditions: a single-center study

Neurology Training and Medical Education in Resource-Limited Settings: Building and Growing the First Neurology Residency Program in East Africa

Omicron variant (B.1.1.529) challenge the integrity of blood brain barrier: Evidence from protein structural analysis

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