Neurological Disorders from Ambient (Urban) Air Pollution Emphasizing UFPM and PM2.5

Bandyopadhyay, Amitava

doi:10.1007/s40726-016-0039-z

Cited by 32 publications

(22 citation statements)

References 31 publications

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“…Airborne PM were considered as one of the abiotic hazardous determinants for the development diseases such as cancer ( Quezada-Maldonado et al., 2018 ), respiratory ( Miller and Peden, 2014 ), cardiovascular ( Ulrich et al., 2002 ) and neurological disorders ( Bandyopadhyay, 2016 ; Crinnion, 2017 ; Genc et al., 2012 ; Loane et al., 2013 ; Xu et al., 2016 ). Presently, emergence of novel infectious microbial pathogens along with air pollution is one of severe threats to the human society globally.…”

Section: Discussionmentioning

confidence: 99%

Particulate matter (PM10) enhances RNA virus infection through modulation of innate immune responses

Mishra

Krishnamoorthy

Gangamma

et al. 2020

Environmental Pollution

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Sensing of pathogens by specialized receptors is the hallmark of the innate immunity. Innate immune response also mounts a defense response against various allergens and pollutants including particulate matter present in the atmosphere. Air pollution has been included as the top threat to global health declared by WHO which aims to cover more than three billion people against health emergencies from 2019 to 2023. Particulate matter (PM), one of the major components of air pollution, is a significant risk factor for many human diseases and its adverse effects include morbidity and premature deaths throughout the world. Several clinical and epidemiological studies have identified a key link between the PM existence and the prevalence of respiratory and inflammatory disorders. However, the underlying molecular mechanism is not well understood. Here, we investigated the influence of air pollutant, PM 10 (particles with aerodynamic diameter less than 10 μm) during RNA virus infections using Highly Pathogenic Avian Influenza (HPAI) – H5N1 virus. We thus characterized the transcriptomic profile of lung epithelial cell line, A549 treated with PM 10 prior to H5N1infection, which is known to cause severe lung damage and respiratory disease. We found that PM 10 enhances vulnerability (by cellular damage) and regulates virus infectivity to enhance overall pathogenic burden in the lung cells. Additionally, the transcriptomic profile highlights the connection of host factors related to various metabolic pathways and immune responses which were dysregulated during virus infection. Collectively, our findings suggest a strong link between the prevalence of respiratory illness and its association with the air quality.

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Section: Discussionmentioning

confidence: 99%

Particulate matter (PM10) enhances RNA virus infection through modulation of innate immune responses

Mishra

Krishnamoorthy

Gangamma

et al. 2020

Environmental Pollution

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“…Beyond disruption of floral scents, diesel air pollution is more widely reported for its direct negative effects on mammalian health, including the cardiovascular system and the central nervous system (CNS) 12,13 . However, we understand very little about direct effects that diesel exhaust pollution has on insect health and behaviour.…”

Section: Introductionmentioning

confidence: 99%

Acute exposure to diesel exhaust induces central nervous system stress and altered learning and memory in honey bees

Reitmayer

Ryalls

Farthing

et al. 2019

Sci Rep

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For effective foraging, many insect pollinators rely on the ability to learn and recall floral odours, behaviours that are associated with a complex suite of cellular processes. Here, we investigated how acute exposure to a high-dose of diesel exhaust (containing 19.8 and 17.5 ppm of NO and NO 2 , respectively) affected associative learning behaviour of honey bees ( Apis mellifera ) and expression of a ubiquitous heat shock protein, HSP70, in their central nervous system (CNS). To determine whether exposure to diesel exhaust would alter their tolerance to a subsequent abiotic stress, we further subjected individuals to heat stress. Diesel exhaust exposure decreased honey bees’ ability to learn and recall a conditioned odour stimulus. Whilst there was no significant difference in CNS HSP70 expression between honey bees exposed to either diesel exhaust or clean air across the entire duration of the experiment (3.5 h), there was a significant effect of time and a significant interaction between exposure treatment and time. This interaction was investigated using correlation analyses, which demonstrated that only in the diesel exhaust exposed honey bees was there a significant positive correlation between HSP70 expression and time. Furthermore, there was a 44% reduction in honey bee individuals that were able to recall the odour 72 h after diesel exposure compared with clean air control individuals. Moreover, diesel exhaust affected A. mellifera in a way that reduced their ability to survive a second subsequent stressor. Such negative effects of air pollution on learning, recall, and stress tolerance has potential to reduce foraging efficiency and pollination success of individual honey bees.

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“…These studies examined the effects of a high dosage of particulate matter exposure, much higher than the concentrations of ambient PM 2.5 typically found in the United States. However, chronic exposure to even small doses of a pollutant may increase risk for neurodegeneration as individuals age (Bandyopadhyay 2016). Two recent U.S. studies with neuroimaging data on older adults found an association between living in areas with higher PM 2.5 concentrations and changes in brain structure, including white matter loss (Chen et al 2015) and reduced cerebral volume (Wilker et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Neighborhood social stressors, fine particulate matter air pollution, and cognitive function among older U.S. adults

Ailshire

Karraker

Clarke

2017

Social Science & Medicine

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A growing number of studies have found a link between outdoor air pollution and cognitive function among older adults. Psychosocial stress is considered an important factor determining differential susceptibility to environmental hazards and older adults living in stressful neighborhoods may be particularly vulnerable to the adverse health effects of exposure to hazards such as air pollution. The objective of this study is to determine if neighborhood social stress amplifies the association between fine particulate matter air pollution (PM2.5) and poor cognitive function in older, community-dwelling adults. We use data on 779 U.S. adults ages 55 and older from the 2001/2002 wave of the Americans’ Changing Lives study. We determined annual average PM2.5 concentration in 2001 in the area of residence by linking respondents with EPA air monitoring data using census tract identifiers. Cognitive function was measured using the number of errors on the Short Portable Mental Status Questionnaire (SPMSQ). Exposure to neighborhood social stressors was measured using perceptions of disorder and decay and included subjective evaluations of neighborhood upkeep and the presence of deteriorating/abandoned buildings, trash, and empty lots. We used negative binomial regression to examine the interaction of neighborhood perceived stress and PM2.5 on the count of errors on the cognitive function assessment. We found that the association between PM2.5 and cognitive errors was stronger among older adults living in high stress neighborhoods. These findings support recent theoretical developments in environmental health and health disparities research emphasizing the synergistic effects of neighborhood social stressors and environmental hazards on residents’ health. Those living in socioeconomically disadvantaged neighborhoods, where social stressors and environmental hazards are more common, may be particularly susceptible to adverse health effects of social and physical environmental exposures.

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Neurological Disorders from Ambient (Urban) Air Pollution Emphasizing UFPM and PM2.5

Cited by 32 publications

References 31 publications

Particulate matter (PM10) enhances RNA virus infection through modulation of innate immune responses

Particulate matter (PM10) enhances RNA virus infection through modulation of innate immune responses

Acute exposure to diesel exhaust induces central nervous system stress and altered learning and memory in honey bees

Neighborhood social stressors, fine particulate matter air pollution, and cognitive function among older U.S. adults

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