2019
DOI: 10.4314/ahs.v19i2.19
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Neurological disorders in HIV in Africa: a review

Abstract: BackgroundNeurological disorders in HIV infection are a common cause of morbidity and mortality. The aim of this paper is to provide a narrative overview of up to date information concerning neurological disorders affecting HIV infected persons in Africa.MethodsSeminal research concerning neurological disorders among HIV-infected adults in sub-Saharan Africa from prior to 2000 was combined with an in-depth search of PubMed to identify literature published from 2000 to 2017. The following Mesh terms were used. … Show more

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Cited by 20 publications
(33 citation statements)
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References 175 publications
(332 reference statements)
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“…Globally, the largest number of individuals with HIV infection reside in sub-Saharan Africa. Recent reviews of HIV-related brain disease in Africa do not describe cases of HIV-CD8E ( 29 , 30 ), however HIV-CD8E may be under-recognized and under-reported in this setting. Between 2018 and 2020, SN has observed several clinico-radiologically-diagnosed cases of HIV-CD8E among Black African ART-treated patients in Cape Town, South Africa (personal observations, unpublished).…”
Section: Discussionmentioning
confidence: 99%
“…Globally, the largest number of individuals with HIV infection reside in sub-Saharan Africa. Recent reviews of HIV-related brain disease in Africa do not describe cases of HIV-CD8E ( 29 , 30 ), however HIV-CD8E may be under-recognized and under-reported in this setting. Between 2018 and 2020, SN has observed several clinico-radiologically-diagnosed cases of HIV-CD8E among Black African ART-treated patients in Cape Town, South Africa (personal observations, unpublished).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, with drug‐resistant TB, various second‐line treatments, such as cycloserine, ethionamide, fluoroquinolones and newer drugs (such as linezolid), can cause PN (26%) 6 . HIV is associated with PN 7 , and the concomitant treatment of HIV and multidrug resistant‐TB can result in PN in ~50% of patients 8 . Long‐term survivors of childhood acute lymphoblastic leukemia can have a high prevalence of PN and in a Malaysian series of 101 acute lymphoblastic leukemia survivors treated with vincristine, 26.7% had an abnormal clinical Total Neuropathy Score, and 68.3% had electrophysiological evidence of neuropathy 9 .…”
Section: Peripheral Neuropathy In Seamentioning
confidence: 99%
“…fold. 8,9 Since early on in the HIV epidemic, multiple cases of HIV-ALS have been described. [10][11][12][13][14][15][16] HIV-ALS can cause a clinical presentation compatible with sporadic ALS (sALS).…”
mentioning
confidence: 99%