Neurological Disorders, other than Stroke, Associated with Antiphospholipid Antibodies in Childhood

Angelini, Lucia; Zibordi, Federica; Zorzi, Giovanna; Nardocci, Nardo; Caporali, Roberto; Ravelli, Angelo; Martini, Alberto

doi:10.1055/s-2007-973766

Cited by 61 publications

(37 citation statements)

References 2 publications

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“…Several reports have indicated a strong relationship between chorea and aPLs levels in patients with SLE, lupus-like disease, or APS [2,3,4,5,6,7]. Asherson et al [2] reported that 9 of 12 chorea patients with SLE or lupus-like disease had elevated levels of aPLs.…”

Section: Discussionmentioning

confidence: 99%

Hemichorea with antiphospholipid antibodies in a patient with lupus nephritis

Watanabe

Onda

2004

Pediatric Nephrology

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Although central nervous system involvement is an important manifestation of systemic lupus erythematosus (SLE), chorea is a relatively uncommon complication. A strong association between chorea and the presence of antiphospholipid antibodies (aPLs) has been reported in patients with SLE, lupus-like disease, or primary antiphospholipid syndrome. We describe a patient with lupus nephritis and cerebral infarction, who subsequently developed recurrent hemichorea associated with increased aPLs levels. A 7-year-old boy suffered from lupus nephritis and a left middle cerebral artery infarction associated with aPLs. He subsequently experienced two episodes of right hemichorea associated with increased aPLs levels without any evidence of further neurological lesions by brain computed tomography or magnetic resonance imaging. The previous left cerebral artery infarction might have increased the susceptibility of the left basal ganglia to the effects of aPLs that contributed to the development of the right hemichorea in this patient.

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Section: Discussionmentioning

confidence: 99%

Hemichorea with antiphospholipid antibodies in a patient with lupus nephritis

Watanabe

Onda

2004

Pediatric Nephrology

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“…Chorea has been described as an isolated clinical manifestation in children with aPL or in association with SLE. [52][53][54][55] There are some data that support the association between migraine and aPL in children. 54 In addition, aPL have been reported in a series of children with partial seizures.…”

Section: Neurological Diseasesmentioning

confidence: 99%

Recent advances in antiphospholipid antibodies and antiphospholipid syndromes in pediatric populations

Avčin

Cimaz

Meroni

2002

Lupus

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In recent years, antiphospholipid antibodies (aPL) and their associated clinical features have been recognized increasingly in various pediatric autoimmune and non-autoimmune diseases. Pathogenic mechanisms involved in pediatric antiphospholipid syndrome (APS) appear to be the same as in adults. However, since pediatric patients do not have prothrombotic risk factors present in adults, there clearly are differences in the spectrum of clinical findings. The frequency of aPL-related thrombotic events is generally low in pediatric populations. On the other hand, various commonly acquired infections are likely to be responsible for higher percentage of non-pathogenic and transient aPL in childhood. Such points have to be considered in clinical judgment of elevated aPL in children. In this review we summarize the recent data on the prevalence and clinical significance of aPL in neonates, children and adolescents.

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“…Dystonia is very rare as a manifestation of APS, although basal ganglia involvement is common in PAPS. Delayed dystonia has been reported in children with secondary or primary antiphospholipid syndrome [13,14], and a case of focal hand dystonia and parkinsonism with basal ganglia lesions has been described by Milanov et al [4].…”

Section: Discussionmentioning

confidence: 99%