Autism (ASM) is a group of neurodevelopmental condition capable of being diagnosed very early in childhood with variety of symptoms such as inability to communicate effectively, aggressive behaviour, and abnormal repetitive routines. The review compares the treatment of ASM with alternative modalities and pharmaceutical medications with evidence that parents prefer to use alternative medicine than pharmaceutical medications in treatment of ASM due to side effects and safety concerns associated with pharmaceutical medications. However, the review also highlights that pharmaceutical medications has no straightforward cure but have specialised drugs that can help manage specific associated symptoms with the syndrome, the (FDA) has only verified 2 drugs for ASM treatment (aripiprazole and risperidone) which help autistic children manage irritability problems associated with ASM syndromes, other drugs have not been adequately studied and not yet approved, therefore there are no evidence to support their use.