Neurological findings spectrum in Celiac disease

Aksoy, Erhan; Teber, Serap; Kansu, Aydan; Deda, Gülhıs

doi:10.24953/turkjped.2016.03.001

Cited by 10 publications

(16 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The spectrum of electroencephalography (EEG) features associated with CD is rather wide, although focal activity in terms of unilateral or bilateral spike or slow waves, mainly localized in the occipital regions, have been reported in most of the wakefulness EEG studies (Magaudda et al, 1993 ; Labate et al, 2001 ; Pratesi et al, 2003 ; Ranua et al, 2005 ; Lionetti et al, 2010 ; Licchetta et al, 2011 ; Aksoy et al, 2016 ). However, as recommended (Parisi et al, 2014 ), EEG patterns should not be considered disease-specific.…”

Section: Neurophysiological Techniques Used To Probe Cns Involvement mentioning

confidence: 99%

“…Although CD may impact the auditory system (Bürk et al, 2001 ), brainstem auditory evoked potentials (BAEPs) and vestibular evoked myogenic potentials were reported to be normal (Pawlak-Osińska et al, 2007 ). More recently, it was found that only 1 of 25 patients had abnormalities in BAEPs in terms of moderate sensorineural hearing loss (Aksoy et al, 2016 ).…”

Section: Neurophysiological Techniques Used To Probe Cns Involvement mentioning

confidence: 99%

“…Complications affecting visual pathways may develop in CD and be evidenced by visual evoked potentials (VEPs) (Bürk et al, 2001 ; Freeman, 2008 ; Hadjivassiliou et al, 2010 ). In particular, patients can show abnormalities on VEPs without evident lesions at neuroimaging (Aksoy et al, 2016 ). A previous case described a slight increase of P100 wave latency bilaterally at pattern-reversal VEPs that reverted back to normal after a GFD (Pellecchia et al, 1999 ).…”

Section: Neurophysiological Techniques Used To Probe Cns Involvement mentioning

confidence: 99%

“…A previous case described a slight increase of P100 wave latency bilaterally at pattern-reversal VEPs that reverted back to normal after a GFD (Pellecchia et al, 1999 ). Given their role in detecting even preclinical pathology in subjects with normal ophthalmological and brain imaging exams, VEPs may provide useful insights in neurologically asymptomatic CD patients (Aksoy et al, 2016 ).…”

Section: Neurophysiological Techniques Used To Probe Cns Involvement mentioning

confidence: 99%

See 3 more Smart Citations

Neurophysiology of the “Celiac Brain”: Disentangling Gut-Brain Connections

et al. 2017

View full text Add to dashboard Cite

Celiac disease (CD) can be considered a complex multi-organ disorder with highly variable extra-intestinal, including neurological, involvement. Cerebellar ataxia, peripheral neuropathy, seizures, headache, cognitive impairment, and neuropsychiatric diseases are complications frequently reported. These manifestations may be present at the onset of the typical disease or become clinically evident during its course. However, CD subjects with subclinical neurological involvement have also been described, as well as patients with clear central and/or peripheral nervous system and intestinal histopathological disease features in the absence of typical CD manifestations. Based on these considerations, a sensitive and specific diagnostic method that is able to detect early disease process, progression, and complications is desirable. In this context, neurophysiological techniques play a crucial role in the non-invasive assessment of central nervous system (CNS) excitability and conductivity. Moreover, some of these tools are known for their valuable role in early diagnosis and follow-up of several neurological diseases or systemic disorders, such as CD with nervous system involvement, even at the subclinical level. This review provides an up-to-date summary of the neurophysiological basis of CD using electroencephalography (EEG), multimodal evoked potentials, and transcranial magnetic stimulation (TMS). The evidence examined here seems to converge on an overall profile of “hyperexcitable celiac brain,” which partially recovers after institution of a gluten-free diet (GFD). The main translational correlate is that in case of subclinical neurological involvement or overt unexplained symptoms, neurophysiology could contribute to the diagnosis, assessment, and monitoring of a potentially underlying CD.

show abstract

Section: Neurophysiological Techniques Used To Probe Cns Involvement mentioning

confidence: 99%

Section: Neurophysiological Techniques Used To Probe Cns Involvement mentioning

confidence: 99%

Section: Neurophysiological Techniques Used To Probe Cns Involvement mentioning

confidence: 99%

Section: Neurophysiological Techniques Used To Probe Cns Involvement mentioning

confidence: 99%

See 2 more Smart Citations

Neurophysiology of the “Celiac Brain”: Disentangling Gut-Brain Connections

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Particularly, TMS changes are often subclinical (mostly referred as a “celiac iceberg”) and further studies require close monitoring of these patients because of the possibility of development of a clinically visible neurological syndrome in patients in different age sets (“symptomatic celiac disease”). The scope of the reported studies was indeed to demonstrate the increased risk of cognitive and neuropsychiatric complications in silent or atypical forms of CD, especially in patients with advanced age or those that are older during the diagnosis period [83]. It is important to note that despite their significant role, neuronal antigens and anti-ganglioside antibodies are not always associated with the neurological status and its complications in the course of CD [70,83,84].…”

Section: Discussionmentioning

confidence: 99%

Cognitive Impairment and Celiac Disease: Is Transcranial Magnetic Stimulation a Trait d’Union between Gut and Brain?

Lanza

Bella

Cantone

et al. 2018

IJMS

View full text Add to dashboard Cite

Celiac disease is a systemic disorder with multifactorial pathogenesis and multifaceted symptomatology. In response to gluten exposure, a significant part of the general population produces antibodies that have been hypothesized to be deleterious to the brain. Among the well-known neurological manifestations, adult celiac patients often complain cognitive symptoms, ranging from the so-called “brain fog” till an overt dementia. Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that can contribute to the assessment and monitoring of celiac patients, even in those without a clear neurological involvement. The studies here reviewed seem to converge on an impaired central motor conductivity and a “hyperexcitable celiac brain” to TMS, which partially reverts back after a long-term gluten restriction. Notably, a clear hyperexcitability is a stably reported feature of both degenerative and vascular dementia. Therefore, given its potential neuroprotective effect, the gluten-free diet should be introduced as early as possible, although the overall response of neurological symptoms (and cognition in particular) is still controversial. Identifying new and possibly modifiable risk factors may be of crucial importance for patients, clinicians, and researchers.

show abstract