2024
DOI: 10.1002/rmv.2581
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Neurological Implications of Poxvirus Infections: Pathogenesis, Neurotropism, and Clinical Manifestations

Mohammed Alissa,
Khalid J. Alzahrani,
Meshari A. Alsuwat

Abstract: Poxviridae is a diverse family of double‐stranded DNA viruses, historically significant for diseases like smallpox caused by variola virus (VARV). These viruses exhibit unique cytoplasmic replication strategies, large genomes encoding numerous proteins, and the ability to cause severe cutaneous and systemic diseases. Recent attention has focused on their neurotropic potential, including mechanisms of CNS invasion, immune‐mediated damage, and clinical manifestations such as encephalitis and myelitis. This revie… Show more

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