2023
DOI: 10.1136/pn-2023-003875
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Neurological involvement by Behçet’s syndrome: clinical features, diagnosis, treatment and outcome

Desmond Patrick Kidd

Abstract: Neurological involvement in Behçet’s syndrome arises predominately through an inflammatory meningoencephalitis characterised by perivenular inflammation due to activation of Th-17 immunological pathways. The brainstem is involved in 50% of cases, the diencephalon and other areas of the brain in 30%, and the spinal cord in 10%. Movement disorders and epilepsy may occur. Psychiatric syndromes may arise with brain and brainstem involvement, and cognitive disorders relate to the brain disease, to circulating infla… Show more

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Cited by 7 publications
(2 citation statements)
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“…The ulcers are often a result of vasculitis in the small or large intestine, leading to tissue necrosis and ulceration [31]. Neurological manifestations can include headaches, strokes, meningitis, or encephalitis [32][33][34]. These can be attributed to vasculitis affecting the central nervous system, with inflammation and possible thrombosis disrupting normal neurological function [35].…”
Section: What Is the Typical Presentation Of Behçet's Disease In Adults?mentioning
confidence: 99%
See 1 more Smart Citation
“…The ulcers are often a result of vasculitis in the small or large intestine, leading to tissue necrosis and ulceration [31]. Neurological manifestations can include headaches, strokes, meningitis, or encephalitis [32][33][34]. These can be attributed to vasculitis affecting the central nervous system, with inflammation and possible thrombosis disrupting normal neurological function [35].…”
Section: What Is the Typical Presentation Of Behçet's Disease In Adults?mentioning
confidence: 99%
“…The interplay between innate immunity and adaptive immunity could sustain the long-term inflammatory condition seen in Behçet's. Behçet's disease has also been linked to regulatory T cell (Treg) dysfunction, which is implicated in immunological homeostasis maintenance [33]. The uncontrolled inflammation and autoimmunity seen in the condition may be attributed in part to impaired Treg activity.…”
Section: What Causes Behçet's Disease?mentioning
confidence: 99%