Neurological Manifestations of Brucellosis in an Indian Population

Tarfarosh, Shah Faisal Ahmad; Manzoor, Mushbiq

doi:10.7759/cureus.684

Cited by 16 publications

(23 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tedavi devamına veya sonlandırılmasına karar verirken hastanın klinik durumunda ve BOS tetkiklerinde düzelme olması gerekir [26]. Tedavi süresi en az altı hafta olmakla birlikte 12 aya kadar uzayabilir [5,6,8]. Steroidlerin tedavideki yeri konusunda kesin görüş birliği olmasa da hastalığın şiddetli formlarında (araknoidit, kraniyal sinir tutulumu, miyelopati, intrakraniyal basınç artı-mı, optik nörit, poliradikülonöropati ve papil ödeminde) önerilmektedir [2,11].…”

Section: Tedaviunclassified

“…çalışmalarındaki %37,5'lik yüksek oranı çalışma grubunun şiddetli hastalığı olup hastanede yatırılarak takip edilen hastalar olmasına bağlamışlardır 4]. Beş yüz elli yedi bruselloz hastasının değerlendirildiği bir çalışmada ileri yaş ve uzamış hastalık sü-resinin santral sinir sistemi hasarı gelişmesinde önemli risk faktörü olduğu belirtilmiştir [5]. Nörobruselloz hastaları sıklıkla baş ağrısı, ateş, terleme ve bulantı, kusma yakınma-ları ile kliniklere başvurmaktadır [3,4,6,7].…”

Section: Introductionunclassified

See 1 more Smart Citation

Neurobrucellosis

Tanyel

2017

Ortadogu Tıp Derg

View full text Add to dashboard Cite

ÖzBrusellosis ülkemizde endemik olarak görülen bir zoonotik hastalıktır ve sıklıkla pastörize olmamış süt ve süt ürün-lerinin tüketilmesi ile bulaşır. Nörobrusellozis hastalığın ciddi bir komplikasyonudur ve hastalığın herhangi bir safhasında gelişebilir. Nörobrusellozda klinik spektrum santral ve periferal olarak sınıflandırılır. En sık görülen klinik tablolar menenjit, meningoensefalit, myelit ve kraniyal sinir paralizileridir. Nörobruselloz vakalarında psikiyatrik tablolar (depresyon, amnezi, psikoz ve ajitasyon) rapor edilmiştir. Beyin omurilik sıvısının incelemesinde protein konsatrasyonu artmış, glukoz konsantrasyonu azalmış ve başlıca lenfositlerden oluşan orta derecede lökosit artışı mevcuttur. Brusella türlerinin beyin omurilik sıvısından izolasyonu düşük olduğundan nörobruselloz vakalarına en sık serolojik yöntemlerle tanı konulmaktadır. Tedavide doksisiklin, rifampisin, siprofloksasin, seftriakson ve trimetoprim-sülfame-taksazol tercih edilir. Etkili tedavi ile sinir sistemi hasarına bağlı sekel azalır. Anahtar kelimeler: Nörobruselloz, klinik tablolar, tedavi AbstractBrucellosis is an endemic zoonotic disease in our country and it is frequently transmitted to humans by ingestion of unpasteurised milk or milk products. Neurobrucellosis is a serious complication of brucellosis and may develop at any stage of disease. The clinical spectrum of neurobrucellosis classified as central and peripheral. The most frequent clinical presentations are meningitis, meningoencephalitis, myelitis and cranial nerve paralyses. The psychiatric manifestations (depression, amnesia, psychosis and agitation) were reported in neurobrucellosis cases. Examination of the cerebrospinal fluid an elevated protein concentration, a depressed glucose concentration and a moderate leukocytosis compodes mainly of lymphocytes. The isolation rate of Brucella species from cerebrospinal fluid is so low, most of the neurobrucellosis cases were diagnosed by serological methods. Doxycyclie, rifampin, ciprofloxacin, ceftriaxone and trimethoprim-sulfamethoxazole preferred in the treatment of neurobrucellosis. Effective treatment reduce the sequelae caused by nervous system damage.

show abstract

Section: Tedaviunclassified

Section: Introductionunclassified

Neurobrucellosis

Tanyel

2017

Ortadogu Tıp Derg

View full text Add to dashboard Cite

show abstract

“…Brucellosis is considered to be eradicated in the United States since the early 1970s; however, sporadic cases of human infection in the US have occurred in the setting of consumption of unpasteurized dairy products from endemic countries [ 5 ]. Brucellosis is caused by a Gram-negative bacterium, Brucella , and is transmitted to humans by contact with infected animals and their bodily fluids or by consuming infected milk or milk products [ 1 – 3 , 6 – 12 ]. The most common symptoms of human brucellosis infection include fever, headache, arthralgia, malaise, and sweating [ 2 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…The most common symptoms of human brucellosis infection include fever, headache, arthralgia, malaise, and sweating [ 2 , 13 , 14 ]. Brucellosis infection of the central nervous system (CNS) is a rare but serious complication [ 6 , 15 ]. We report a case of neurobrucellosis mimicking the symptoms, laboratory data, and the pathologic findings that can be seen in systemic lupus erythematosus (SLE), thus demonstrating the diagnostic challenges of such a heterogeneous disease.…”

Section: Introductionmentioning

confidence: 99%

An Interesting Case of Neurobrucellosis Mimicking Neuropsychiatric Lupus

Bains

Dahhan

Belzowski

et al. 2018

Case Reports in Rheumatology

View full text Add to dashboard Cite

This case describes a patient presenting with acute onset papilledema, subacute strokes resulting in upper extremity weakness and numbness, arthritis, maculopapular rash, depressed C4 and CH50, and a high titer anti-double-stranded DNA antibody. The patient was given the diagnosis of probable systemic lupus erythematosus, which was supported by the Systemic Lupus International Collaborating Clinics (SLICC) criteria. He was aggressively treated for neuropsychiatric lupus (NPSLE) with pulse dose steroids and a dose of intravenous cyclophosphamide. Blood cultures drawn on admission later grew out 2/4 bottles of Gram-variable bacteria, speciated as Brucella melitensis by PCR. Serum Brucella serologies were also positive. On further evaluation, the patient noted a history of eating unpasteurized cheese in Mexico. Given these additional findings, the patient's presentation was most consistent with a diagnosis of neurobrucellosis. Steroids were tapered off, no further doses of cyclophosphamide were given, and a prolonged course of intravenous and oral antibiotic therapy was administered, resulting in complete resolution of the patient's presenting symptoms.

show abstract

“…The most frequent forms of neurological involvement are meningitis and meningoencephalitis. It may be difficult to distinguish neurobrucellosis from other forms of meningitis because it may be in the form of acute or chronic meningitis (23). Meningitis can be a complication that occurs in the late period of the disease as well as in early stages.…”

Section: Neurobrucellosismentioning

confidence: 99%

An old foe still with us: Troubling issues with brucellosis

Buzğan¹,

Hasanoğlu²

2017

Med J Islamic World Acad Sci

View full text Add to dashboard Cite

Clinical featuresBrucellosis can be subclinical, acute, subacute, and chronic. It can present itself with nonspecific symptoms such as fever, night sweats, loss of appetite, weight loss, weakness, headache, and polyarthritis (2,5-7). Brucellosis should be considered as a differential diagnosis for fevers of unknown origin. Debilitating conditions such as arthralgia, myalgia, and back pain affects around half of the patients. The incubation period is 2-3 weeks. Physical findings may vary depending on the duration of the disease. Systemic brucellosis sometimes can be complicated with meningitis, endocarditis, septic arthritis, and osteomyelitis. These complications are not extremely rare. A large meta-analysis reported the prevalence of endocarditis and neurobrucellosis as 1% and 4%, respectively (6). Osteoarticular complications are the most common complications of brucellosis (2,6,8).Relapse can occur 2-3 months after the treatment and can be detected with serologic tests and blood culture positivity. Relapse rate is common in cases treated with a single antibiotic regimen and short-term treatment. SUMMARYAlthough brucellosis is an old disease, it is still challenging for physicians. In this review, we discussed common pitfalls of brucellosis.

show abstract

Neurological Manifestations of Brucellosis in an Indian Population

Cited by 16 publications

References 15 publications

Neurobrucellosis

Neurobrucellosis

An Interesting Case of Neurobrucellosis Mimicking Neuropsychiatric Lupus

An old foe still with us: Troubling issues with brucellosis

Contact Info

Product

Resources

About